CUGBP1 antibody

Principal name

CUGBP1 antibody

Alternative names for CUGBP1 antibody

CELF-1, BRUNOL2, CELF1, CUGBP, NAB50, Bruno-like protein 2, CUG-BP- and ETR-3-like factor 1,RNA-binding protein BRUNOL-2, CUG triplet repeat RNA-binding protein 1, Deadenylation factor CUG-BP, 50 kDa nuclear polyadenylated RNA-binding protein, Embryo deadenylation element-binding protein homolog

SwissProt ID

P28659 (Mouse), Q28HE9 (Xentr), Q4QQT3 (Rat), Q5F3T7 (Chick), Q8R532 (Mouse), Q92879 (Human)

Gene ID

10658 (CELF1), 13046 (Celf1), 362160

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Rb (Rabbit), Chk (Chicken), Ze (Zebrafish), Por (Porcine), Can (Canine), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CUGBP1 antibody

Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3'-untranslated region of the myotonin protein kinase gene (DMPK). CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPbeta transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPbeta mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5' region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawal.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CUGBP1 antibody

  anti-CUGBP1 mouse monoclonal antibody, clone OTI5B8 (formerly 5B8)  
Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-CUGBP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500951, Dilution 1:50) Mouse IgG2b OTI5B8 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CUGBP1 antibody

  Mouse Monoclonal Antibody against CUG-BP1 (3B1)  
Detection of CUG-BP1 in several cell lysates Mouse IgG1 3B1 Purified Bov, Hu, Ms, Por, Rb, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CUGBP1 antibody

  Rabbit polyclonal anti-CELF-1 antibody  
Western blot analysis of extracts from HeLa cells and HepG2 cells, using CELF-1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CUGBP1 antibody

  Rabbit Polyclonal Anti-CUGBP1 Antibody  
Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CUGBP1 (+CUGBP2) antibody

Immunohistochemistry (IHC) analyzes of CUG-BP1/2 antibody (Cat.-No.: AP20451PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CUGBP1 antibody

Western blot analysis of extracts from HeLa/HepG2 cells, using CELF-1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

CUGBP1 antibody

Western blot analysis of extracts from HeLa/HepG2 cells, using CELF-1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CELF1 - human gene knockout kit via CRISPR

CELF1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CELF1 - human gene knockout kit via CRISPR

CELF1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CELF1 - human gene knockout kit via CRISPR

CELF1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CELF1 - human gene knockout kit via CRISPR

CELF1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Celf1 - mouse gene knockout kit via CRISPR

Celf1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Celf1 - mouse gene knockout kit via CRISPR

Celf1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Celf1 - mouse gene knockout kit via CRISPR

Celf1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Celf1 - mouse gene knockout kit via CRISPR

Celf1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CUGBP1 (transcript variant 1)

  Recombinant protein of human CUG triplet repeat, RNA binding protein 1 (CUGBP1), transcript variant 1  
CUGBP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

CUGBP1 (transcript variant 2)

  Recombinant protein of human CUG triplet repeat, RNA binding protein 1 (CUGBP1), transcript variant 2  
CUGBP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

CELF1 overexpression lysate

CELF1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

CELF1 overexpression lysate

CELF1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

CELF1 overexpression lysate

CELF1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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