Cullin-4A antibody

Principal name

Cullin-4A antibody

Alternative names for Cullin-4A antibody

CUL-4A, CUL4A

SwissProt ID

Q13619 (Human), Q3TCH7 (Mouse)

Gene ID

8451 (CUL4A), 99375 (Cul4a)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Cullin-4A antibody

CUL4a is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitiantion of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cullin-4A (N-term) antibody

  Rabbit Polyclonal Antibody against CUL4A (N-term)  
Western blot analysis of CUL4a (arrow) using rabbit polyclonal CUL4a Antibody (Human N-term) (Cat.#TA302188).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CUL4a gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cullin-4A (N-term) antibody

  Rabbit polyclonal anti-Cul4A antibody  
Immunohistochemistry. anti-CUL4 antibody was diluted 1:500 to detect CUL4 in human testes tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. Rabbit Serum Hu, Ms E, IP, P, WB
0.1 ml / €356.00
  OriGene Technologies, Inc.

Cullin-4A antibody

  Anti-CUL4A Rabbit Polyclonal Antibody  
Western blot analysis of Human fetal muscle and fetal brain tissue, hela cell using TA321259(CUL4A Antibody) at dilution 1/325 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cullin-4A antibody

  Anti-CUL4A Rabbit Polyclonal Antibody  
Western blot analysis of Human fetal muscle and brain tissue using TA321260(CUL4A Antibody) at dilution 1/450 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cullin-4A antibody

Testis: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Hu, Ms E, IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CUL4A - human gene knockout kit via CRISPR

CUL4A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CUL4A - human gene knockout kit via CRISPR

CUL4A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CUL4A - human gene knockout kit via CRISPR

CUL4A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CUL4A - human gene knockout kit via CRISPR

CUL4A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cul4a - mouse gene knockout kit via CRISPR

Cul4a - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cul4a - mouse gene knockout kit via CRISPR

Cul4a - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cul4a - mouse gene knockout kit via CRISPR

Cul4a - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cullin-4A (transcript variant 2)

  Purified recombinant protein of Homo sapiens cullin 4A (CUL4A), transcript variant 2  
Cullin-4A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CUL4A overexpression lysate

CUL4A overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

CUL4A overexpression lysate

CUL4A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

CUL4A overexpression lysate

CUL4A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CUL4A (mGFP-tagged) - Human cullin 4A (CUL4A), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, CUL4A (mGFP-tagged) - Human cullin 4A (CUL4A), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CUL4A (mGFP-tagged) - Human cullin 4A (CUL4A), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, CUL4A (mGFP-tagged) - Human cullin 4A (CUL4A), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CUL4A (Myc-DDK tagged) - Human cullin 4A (CUL4A), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, CUL4A (Myc-DDK tagged) - Human cullin 4A (CUL4A), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, CUL4A (Myc-DDK tagged) - Human cullin 4A (CUL4A), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, CUL4A (Myc-DDK tagged) - Human cullin 4A (CUL4A), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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