Cullin-4B antibody

Principal name

Cullin-4B antibody

Alternative names for Cullin-4B antibody

CUL-4B, CUL4B, KIAA0695

SwissProt ID

Q13620 (Human)

Gene ID

8450 (CUL4B)

Available reactivities

Hu (Human), Rt (Rat), Can (Canine), Ms (Mouse), Ze (Zebrafish), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Cullin-4B antibody

Cullin 4B/CUL4B encodes a scaffold protein that organizes a cullin-RING (really interesting new gene) ubiquitin ligase (E3) complex in ubiquitylation. The CUL4 gene encodes a protein of 913 amino acids. The cullin domain is located between amino acid residues 217 and 815 and is characterized a by C-terminal globular domain (cullin homology domain) and a series of N-terminal repeats (cullin repeats). Ohtake et al. (2007) characterize a fat-soluble ligand-dependent ubiquitin ligase complex in human cell lines, in which dioxin receptor (AhR) is integrated as a component of a novel cullin 4B ubiquitin ligase complex, CUL4B(AhR). Complex assembly and ubiquitin ligase activity of CUL4B(AhR) in vitro and in vivo are dependent on the AhR ligand. In the CUL4B(AhR) complex, ligand-activated AhR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation. Their findings uncover a function for AhR as an atypical component of the ubiquitin ligase complex and demonstrate a non-genomic signalling pathway in which fat-soluble ligands regulate target-protein-selective degradation through a ubiquitin ligase complex.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cullin-4B antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-CUL4B Rabbit Polyclonal antibody. (TA590752) Rabbit IgG Purified Hu E, ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cullin-4B antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-CUL4B mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800444) Mouse IgG2b OTI1C4 Purified Can, Hu, Ms P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Cullin-4B antibody

Western blot analysis of CUL4B Antibody (Center) Pab (Cat. #TA324698) pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate. CUL4B Antibody (Center) (arrow) was detected using the purified Pab. Rabbit IgG Purified Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Cullin-4B antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CUL4B (RC206935, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CUL4B. Mouse IgG1 OTI7G10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cullin-4B antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CUL4B (RC206935, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CUL4B. Mouse IgG1 OTI7F8 Purified Can, Hu, Mky, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cullin-4B antibody

Cullin 4B CUL4B Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Rt, Ze P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Cullin-4B antibody

Immunofluorescence of purified MaxPab antibody to CUL4B on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Cullin-4B antibody

Immunohistochemical staining of CUL4B on formalin fixed, paraffin embedded Zebrafish body with CUL4B polyclonal antibody ( Cat # PAB12320 ). Rabbit Hu, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Cullin-4B antibody

Cullin-4B Rabbit IgG Aff - Purified Hu, Ms, Rt, Ze P, WB
0.1 mg / €290.00
  Boster Immunoleader

Cullin-4B antibody

Western Blot: CUL4B Antibody [25150002] - Samples:  Lane 1, Marker [kDa]: 250, 130, 95, 72, 55, 36, 28, 17, 11  Lane 2, RT-4  Lane 3, U-251MG sp  Lane 4, Human Plasma  Lane 5, Liver  Lane 6, Tonsil , Target weight [kDa]:  104, 103, 102 (splice variants)   Validation score:  2   Validation description:  Supportive - Band of predicted size in kDa (+/-20%) with additional bands present. Rabbit Hu E, P, WB
50 µg / €440.00
  Novus Biologicals Inc.

Cullin-4B antibody

Immunohistochemistry: CUL4B Antibody (EPR3200) [NBP1-40587] -  Immunohistochemical staining of paraffin-embedded brain tissue using anti-CUL4A/B Rabbit IgG EPR3200 Hu, Ms, Rt F, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Cullin-4B antibody

Immunohistochemistry-Paraffin: CUL4B Antibody [NBP1-86099] - Immunohistochemical staining of human cerebellum shows strong nuclear positivity in Purkinje cells. Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cullin-4B (transcript variant 1)

Cullin-4B Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Cullin-4B

Cullin-4B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Cullin-4B

Cullin-4B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CUL4B 293T Cell Transient Overexpression Lysate(Denatured)

CUL4B 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

16 Item(s)

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