CXCL10 / IP-10 antibody

Principal name

CXCL10 / IP-10 antibody

Alternative names for CXCL10 / IP-10 antibody

C-X-C motif chemokine 10, Small-inducible cytokine B10, Gamma-IP10, INP10, SCYB10, 10 kDa interferon-gamma-induced protein

SwissProt ID

P02778 (Human), P17515 (Mouse), P48973 (Rat), Q2KIQ8 (Bovin), Q5KSV9 (Canfa)

Gene ID

3627 (CXCL10), 15945 (Cxcl10), 245920, 100045000, 615107

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Gt (Goat), Sh (Sheep)

Available hosts

Rabbit, Mouse, Goat, Chicken, Sheep, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), Neutralisation (NEUT), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection)), ELISA (capture) (E(capture))

Background of CXCL10 / IP-10 antibody

The monoclonal antibody 6D4 recognizes human C-X-C motif chemokine 10 (IP-10), a protein of 98 amino acids. IP-10, also known as CXCL10, functions as ligand for the CXCR3 receptor. IP-10 belongs to the a-chemokine (C-X-C) family, which can be divided in two subfamilies: (1) potent chemoattractants for neutrophils, like IL-8 and (2) potent chemoattractants for lymphocytes, like the IFNg inducible protein (IP)-10. IP-10 is produced by a wide variety of cell types ranging from neutrophils, dendritic cells and monocytes to hepatocytes, endothelial cells and keratinocytes. The cytokine is reported to be involved in a scala of inflammatory pathologies such as HIV, encephalitis, cutaneous T cell lymphoma, chronic hepatitis, psoriasis and acute anterior uveitis. Various observations strongly suggest a role for the C-X-C chemokines IL-8 and IP-10 in the regulation of angiogenic activity in cancer and in idiopathic pulmonary fibrosis. Furthermore IP-10 is associated with acute rejection processes estimated by the predictive properties of urinary IP-10 expression for the short- and long-term graft function after kidney transplantation.

General readings

General / background references:Loetscher M et al. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med 184:963-9 (1996). PubMed PMID: 9064356
Wang X et al. Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response. J Biol Chem 271:24286-93 (1996). PubMed PMID: 8798675

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CXCL10 / IP-10 antibody

Western blot analysis of IP-10 in EAE rat brain. Rabbit Purified Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL10 / IP-10 antibody

To detect hIP-10 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hIP-10. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CXCL10 / IP-10 antibody

To detect hIP-10 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human IP-10 (TA328356) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIP-10. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL10 / IP-10 antibody

To detect mIP-10 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant mIP-10. Rabbit IgG Purified E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CXCL10 / IP-10 antibody

To detect mIP-10 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine IP-10 (TA328522) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mIP-10. Rabbit IgG Purified E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL10 / IP-10 antibody

To detect Rat IP-10 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant Rat IP-10 . Rabbit IgG Purified Rt E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CXCL10 / IP-10 antibody

To detect Rat IP-10 by sandwich ELISA (using 100ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Rat IP-10 (TA328586) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat IP-10. Rabbit IgG Purified Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL10 / IP-10 antibody

ELISA: CXCL10/INP10 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL10 / IP-10 antibody

Western Blot (Reduced) using CXCL10 / IP-10 Antibody Cat.-No AM20277PU-N Mouse Azide Free Hu E, WB
0.5 mg / €220.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

CXCL10 / IP-10 Mouse IgG2a 6D4 Biotin Hu C, E, F, ICC/IF, WB
50 µg / €250.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

CXCL10 / IP-10 Mouse IgG2a 6D4 FITC Hu C, E, ICC/IF, WB
0.1 mg / €290.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

CXCL10 / IP-10 Mouse IgG2a 6D4 Purified Hu C, E, ICC/IF, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

We used U937 cells 3 days after passaging. Half were activated with IFN-gamma 100ng/ml for 20 hours and half were used as control. Cell concentration at the beginning of activation was 2.105 cells/ml. Brefaldin A was used as an intracellular blocking agent at 1µg/ml, in contact with the cells for 4 to 6 hours. The graph on the left represents activated U937 cells marked with B-C50 and the graph on the right shows B-C50 with non-activated U937 cells. In the two cases, the dotted line represents the IgG2a isotype control (B-Z2). Mouse IgG2a B-C50 Azide Free Hu F
0.5 mg / €460.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

We used U937 cells 3 days after passaging. Half were activated with IFN-gamma 100 ng/ml for 20 hours and half were used as control. Cell concentration at the beginning of activation was 2.10e5 cells/ml. Brefaldin A was used as an intracellular blocking agent at 1µg/ml, in contact with the cells for 4 to 6 hours. The black line on the graph represents the IgG2b isotype control (B-E4), the green line shows B-C50 with U937 non-activated cells and the yellow line represents activated U937 cells marked with  B-C50 (10µl per test for 5.10e5 cells). Mouse IgG2a B-C50 FITC Hu F
1ml (100Tests) / €270.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

CXCL10 / IP-10 Mouse IgG2a B-C50 Purified Hu F
2ml (200 Tests) / €250.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

CXCL10 / IP-10 Mouse IgG2a B-C55 Azide Free Hu
0.5 mg / €460.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

CXCL10 / IP-10 Mouse IgG2a B-C50 Azide Free Hu E(capture)
1 mg / €790.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

CXCL10 / IP-10 Mouse IgG2a B-C55 Biotin Hu E(detection)
0.1 mg / €460.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

CXCL10 / IP-10 Mouse IgG2a 6D4 Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CXCL10 / IP-10 antibody

CXCL10 / IP-10 Mouse IgG2a 6D4 Purified Hu E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

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