CXCL12 / SDF1 antibody

Principal name

CXCL12 / SDF1 antibody

Alternative names for CXCL12 / SDF1 antibody

Stromal cell-derived factor 1, SDF1A, SDF1B, IRH, hIRH, PBSF, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, Pre-B cell growth-stimulating factor

SwissProt ID

F7DYQ8, O62657 (Felca), P40224 (Mouse), P48061 (Human), Q5EBF6 (Xentr), Q80YV8 (Rat), Q8UUJ9 (Xenla)

Gene ID

6387 (CXCL12), 20315 (Cxcl12), 63874 (ABHD4), 24772, 493806

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Por (Porcine), Rt (Rat), African clawed frog, Ms (Mouse)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Functional assay (FN), Paraffin Sections (P), Neutralisation (NEUT), Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F)

Background of CXCL12 / SDF1 antibody

SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemoattractant for T cells and monocytes, but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven-pass, transmembrane domain proteins which include IL-8RA, IL-8RB and fusin (also designated LESTR or CXCR-4). Fusin is highly homologous to the IL-8 receptors, sharing 37% sequence identity at the amino acid level. The IL-8 receptors bind to IL-8, NAP-2 and MSGA, while fusin binds to its cognate ligand, SDF-1. Fusin has been identified as the major co-receptor for T-tropic HIV-1, and SDF-1 has been shown to inhibit HIV-1 infection. Six human SDF-1 isoforms exist due to alternative splicing of CXCL12, the gene encoding SDF-1.

General readings

1. Jiang, S. Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS ONE.;2:e641. 2007.
2. Chen Z, The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway Blood. ;110(1):171-9. 2007.
3. Bai, A. Kruppel-Like Factor 2 Controls T Cell Trafficking by Activating L-Selectin (CD62L) and Sphingosine-1-Phosphate Receptor 1 Transcription. The Journal of Immunology.;178(12):7632-9. 2007.
4. Al-Alwan, M. Follicular Dendritic Cell Secreted Protein (FDC-SP) Regulates Germinal Center and Antibody Responses The Journal of Immunology.;178(12):7859-67. 2007.
5. Su, G. Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation. The Journal of Biological Chemistry.;282(20):14906-15. 2007.
6. Dhanjal TS A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice Blood. ;109(10):4237-44. 2007.
7. Alcaide P, Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue J Exp Med. ;204(2):431-9. 2007.
8. Pello OM, SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade Blood. ;108(12):3928-37. 2006.
9. Campello S, Orchestration of lymphocyte chemotaxis by mitochondrial dynamics. J Exp Med. 2006.
Kabashima K, Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism J Exp Med., 2006, 203(12):2683-90.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CXCL12 / SDF1 (alpha) antibody

CXCL12 / SDF1 Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (alpha) antibody

CXCL12 / SDF1 Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (alpha) antibody

Formalin-Fixed, Paraffin-Embedded Sections of Human colorectal adenocarcinoma stained with CXCL12 / SDF1 Antibody Cat.-No PP1067P Rabbit Aff - Purified Hu E, FN, P, WB
50 µg / €230.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (alpha) antibody

Formalin-Fixed, Paraffin-Embedded Sections of Human colorectal adenocarcinoma stained with CXCL12 / SDF1 Antibody Cat.-No PP1067P Rabbit Aff - Purified Hu E, FN, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CXCL12 / SDF1 antibody

Western blot analysis of SDF-1beta expression in transfected cells. Rabbit Purified Ms, Rt IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL12 / SDF1 antibody

Predicted cell location: Cytoplasm. Positive control: Human ovarian and breast cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using CXCL12 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CXCL12 / SDF1 antibody

Predicted cell location: Cytoplasm. Positive control: Human breast and cervical cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using CXCL12 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CXCL12 / SDF1 antibody

Western blot analysis of CXCL12 in HeLa cell lysate with CXCL12 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Purified Hu, Ms ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL12 / SDF1 antibody

This antibody stained formalin-fixed, paraffin-embedded sections of human colorectal adenocarcinoma.  The recommended concentration is 0.5 ug/ml with an overnight incubation at 4C.  An HRP-labeled polymer detection system was used with a DAB chromogen.  Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended.  Optimal concentrations and conditions may vary.      *Additional  Immunostaining data available. Please contact Tech Support for information. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL12 / SDF1 antibody

WB Suggested Anti-CXCL12 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Lung Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CXCL12 / SDF1 antibody

Western blot analysis of SDF 1 expression in HepG2 cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL12 / SDF1 antibody

Immunohistochemistry analysis of SDF-1 Antibody (Cat.-No AP20632PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (beta) antibody

CXCL12 / SDF1 Goat IgG Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (beta) antibody

CXCL12 / SDF1 Goat IgG Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (beta) antibody

CXCL12 / SDF1 Goat IgG Aff - Purified Hu E, FN, P, WB
50 µg / €230.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (beta) antibody

CXCL12 / SDF1 Goat IgG Aff - Purified Hu E, FN, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (alpha) antibody

CXCL12 / SDF1 Goat Biotin Ms E, WB
25 µg / €230.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (alpha) antibody

CXCL12 / SDF1 Goat Biotin Ms E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (alpha) antibody

Western Blot (Reduced) using CXCL12 / SDF1 Antibody Cat.-No PP1217P Goat Aff - Purified Ms E, NEUT, WB
50 µg / €230.00
  Acris Antibodies GmbH

CXCL12 / SDF1 (alpha) antibody

Western Blot (Reduced) using CXCL12 / SDF1 Antibody Cat.-No PP1217P Goat Aff - Purified Ms E, NEUT, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

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