CXCL2 / MIP2A antibody

Principal name

CXCL2 / MIP2A antibody

Alternative names for CXCL2 / MIP2A antibody

C-X-C motif chemokine 2, GRO2, GROB, MIP-2A, SCYB2, Gro-beta, MIP2-alpha, Macrophage inflammatory protein 2-alpha, Growth-regulated protein beta

SwissProt ID

P10889 (Mouse), P19875 (Human), P30348 (Rat)

Gene ID

20310 (Cxcl2), 114105, 2920 (CXCL2)

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse)

Available hosts

Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), Neutralisation (NEUT), Immunoprecipitation (IP), Paraffin Sections (P)

Background of CXCL2 / MIP2A antibody

Mouse macrophage inflammatory protein-2 (MIP-2), also known as CXCL2, was originally identified as a heparin-binding protein secreted by an LPS-stimulated mouse macrophage cell line . A cDNA clone encoding the protein was isolated from this cell line and characterized . Based on its protein and DNA sequences, mouse MIP-2 was classified as a member of the alpha (CXC) chemokine family of inflammatory and immunoregulatory cytokines .

Mouse MIP-2 cDNA encodes a 100 amino acid residue precursor protein from which the amino-terminal 27 amino acid residues are cleaved to generate the mature mouse MIP-2. The protein sequence of mouse MIP-2 shows approximately 63% identity to that of mouse KC, another mouse alpha chemokine. Mouse MIP-2 is also 60% identical to human GRO. and GRO.. Based on these protein sequence similarities, it is likely that mouse KC and MIP-2 are homologs of human GRO., . and . chemokines. Since chemokines with protein sequence homology to human IL-8 have not been identified in mice, it has been suggested that the mouse KC and MIP-2 are functional homologs of human IL-8 in mice . A putative mouse homolog of the human IL-8 receptor beta (IL-8 R.) has also been cloned. This receptor shows 71% identity to human IL-8 R. and 68% identity to human IL-8 R.. Both mouse KC and MIP-2 bind mouse IL-8 R. with high affinity .

Like human IL-8, mouse MIP-2 exhibits potent neutrophil chemotactic activity and may be a key mediator of neutrophil recruitment in response to tissue injury and infection . Increased MIP-2 expression has been found to be associated with neutrophil influx in various inflammatory conditions .

General readings

Wolpe, S.D. et al. (1989) Proc. Natl. Acad. Sci. USA 86:612.

Tekamp-Olson, P. et al. (1990) J. Exp. Med. 172:911.

Schall, T. (1994) in The Cytokine Handbook, 2nd ed., A. Thomson, ed., Academic Press, New York, p. 419.

Driscoll, K.E. (1994) Exp. Lung Res. 20:473.

Heinrich, J. and R. Bravo (1995) J. Biol. Chem. 270:4987.

Standiford, T.J. et al. (1996) J. Leukoc. Biol. 59:24.

Su, Y.H. et al. (1996) J. Virol. 70:1277.

Greenberger, M.J. et al. (1996) J. Infect. Dis. 173:159.

Seebach, J. et al. (1995) J. Immunol. 155:4367.

Standiford, T.J. et al. (1995) J. Immuno. 155:2222.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CXCL2 / MIP2A antibody

CXCL2 / MIP2A Rabbit Biotin Ms E, WB
25 µg / €230.00
  Acris Antibodies GmbH

CXCL2 / MIP2A antibody

CXCL2 / MIP2A Rabbit Biotin Ms E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CXCL2 / MIP2A antibody

Western Blot (Unreduced) using CXCL2 / MIP2A Antibody Cat.-No PP1082P Rabbit Aff - Purified Ms E, FN, NEUT, WB
50 µg / €230.00
  Acris Antibodies GmbH

CXCL2 / MIP2A antibody

Western Blot (Unreduced) using CXCL2 / MIP2A Antibody Cat.-No PP1082P Rabbit Aff - Purified Ms E, FN, NEUT, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CXCL2 / MIP2A (C-term) antibody

  Goat Anti-CXCL2 / MIP-2 Antibody  
(0.2ug/ml) staining of Human Duodenum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL2 / MIP2A antibody

  Biotinylated Anti-Human GRO-ß Rabbit Polyclonal Antibody  
To detect Human GRO-beta by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant Human GRO-beta. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CXCL2 / MIP2A antibody

  Anti-Human GRO-ß Rabbit Polyclonal Antibody  
To detect Human GRO-beta by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human GRO-beta (TA328331) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human GRO-beta. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL2 / MIP2A antibody

  Biotinylated Anti-Murine MIP-2 Rabbit Polyclonal Antibody  
To detect mMIP-2 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant mMIP-2. Rabbit IgG Purified E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CXCL2 / MIP2A antibody

  Anti-Murine MIP-2 Rabbit Polyclonal Antibody  
To detect mMIP-2 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine MIP-2 (TA328544) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant mMIP-2. Rabbit IgG Purified E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL2 / MIP2A antibody

  Biotinylated Anti-Rat GRO-ß/MIP-2 Rabbit Polyclonal Antibody  
To detect Rat GRO-beta/MIP-2 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant Rat GRO-beta/MIP-2.. Rabbit IgG Purified Rt E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CXCL2 / MIP2A antibody

  Anti-Rat GRO-ß/MIP-2 Rabbit Polyclonal Antibody  
To detect Rat GRObeta/MIP-2 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Rat GRObeta/MIP-2 (TA328580) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat GRObeta/MIP-2. Rabbit IgG Purified Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCL2 / MIP2A antibody

CXCL2 / MIP2A Rabbit Biotin Rt E, WB
25 µg / €230.00
  Acris Antibodies GmbH

CXCL2 / MIP2A antibody

CXCL2 / MIP2A Rabbit Biotin Rt E, WB
50 µg / €340.00
  Acris Antibodies GmbH

CXCL2 / MIP2A antibody

CXCL2 / MIP2A Rabbit Aff - Purified Rt E, FN, WB
50 µg / €230.00
  Acris Antibodies GmbH

CXCL2 / MIP2A antibody

CXCL2 / MIP2A Rabbit Aff - Purified Rt E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CXCL2 / MIP2A antibody

CXCL2 / MIP2A Rabbit Aff - Purified Hu E, FN, WB
50 µg / €230.00
  Acris Antibodies GmbH

CXCL2 / MIP2A antibody

CXCL2 / MIP2A Rabbit Aff - Purified Hu E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CXCL2 / MIP2A antibody

CXCL2 / MIP2A Rabbit Purified Ms, Rt IP, WB
0.5 mg / €290.00
  Torrey Pines Biolabs

CXCL2 / MIP2A antibody

CXCL2 / MIP2A Rabbit Azide Free Ms, Rt IP, WB
0.5 mg / €290.00
  Torrey Pines Biolabs

CRISPR

Catalog No. Species Donor Vector  

CXCL2 - human gene knockout kit via CRISPR

CXCL2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

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