CXCR7 / GPR159 antibody

Principal name

CXCR7 / GPR159 antibody

Alternative names for CXCR7 / GPR159 antibody

CXC-R7, CXCR-7, CMKOR1, GPR-159, RDC1, C-X-C chemokine receptor type 7,G-protein coupled receptor RDC1 homolog, Chemokine orphan receptor 1, G-protein coupled receptor 159

SwissProt ID

O89039 (Rat), P11613 (Canfa), P25106 (Human), P56485 (Mouse)

Gene ID

57007 (CXCR7), 12778 (Cxcr7)

Available reactivities

Bt (Bat), Bov (Bovine), Can (Canine), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Rt (Rat), Bear, Eq (Equine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CXCR7 / GPR159 antibody

Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells. Chemokine receptors (CXCR) belong to the super-family of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and proliferation and migration of immature neurons, glia and their precursors (1). Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases Several subtypes of CXCR have been characterized.
Activation of naïve T cells by specific antigen and cytokines, up-regulate cell adhesion molecules (CAM) as well as chemokine receptors on their surface, which directs them to migrate towards the inflamed tissues. Chemokine receptor type 3 (CXCR3) is induced during T cell activation and CXCR3 positive cell are enriched at the inflammatory site (2). On the contrary, glucocorticoid dexamethasone has potent anti-inflammatory effects, yet it up-regulates expression of CXCR4 but not that of CXCR1 and CXCR3 (4).
The chemokine receptor 7 protein is approximately 43-44 kDa (378 amino acids) protein which has 7 transmembrane domains, characteristic of G-protein coupled receptors. The all CXCR sequence analyses suggest the presence of 7 transmembrane domains, a characteristic feature of GPCR. The protein has putative N-glycosylation sites near the extra cellular N-terminal end of the proteins. The protein has a large 3rd intra cellular loop which interacts with G-proteins. The short carboxy terminal is intracellular and has putative post-translational sites. The Anti-CXCR-selective antibodies were generated against conserved but unique sequences on various CXCR receptors that are expressed only in a particular CXCR receptor subtype.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CXCR7 / GPR159 (N-term) antibody

CXCR7 / GPR159 Rabbit Aff - Purified Hu, Ms, Rt C, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CXCR7 / GPR159 (2nd Extracell. Dom.) antibody

Immunohistochemical staining of Kidney (Renal tubule) using anti- CXCR7 antibody SP4312P Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Hst, Hu, Mky, Ms, Op, Platypus, Por, Prim, Rb, Rt F, P
50 µg / €470.00
  Acris Antibodies GmbH

CXCR7 / GPR159 (311-360) antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CXCR7 / GPR159 antibody

Western blot analysis of extracts from COS-7 cells, using CXCR7 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CXCR7 / GPR159 antibody

Western Blot: CXCR7 Antibody [TA337066] - Analysis of human CXCR7/RDC1 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using this antibody. Rabbit IgG Purified Bov, Eq, Hu, Ms, Prim, Rt F, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXCR7 / GPR159 antibody

Anti-CXCR7 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Can, Hu, Mky WB
50 µg / €379.00
  OriGene Technologies, Inc.

CXCR7 / GPR159 antibody

Anti-CXCR7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

CXCR7 / GPR159 antibody

Flow cytometric analysis of human CXCR7 expression on transiently transfected 293T (left) and 293T (right). Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26573AF-N to the cells. Mouse IgG1 9C4 Azide Free Hu F, P
0.1 mg / €450.00
  Acris Antibodies GmbH

CXCR7 / GPR159 control peptide

CXCR7 / GPR159 Aff - Purified
0.25 mg / €250.00
  Acris Antibodies GmbH

CXCR7 / GPR159 (C-term) antibody

Western blot analysis of CXCR7 Antibody (C-term) (Cat.-No AP17961PU-N) in Ramos cell line (Left) and in mouse lung tissue (Right) lysates (35ug/lane). CXCR7 (arrow) was detected using the purified Pab. Rabbit Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CXCR7 / GPR159 (C-term) antibody

AP33489PU-N (2µg/ml) staining of Human Breast cancer lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CXCR7 / GPR159 (C-term) antibody

CMKOR1 Antibody (C-term) (Cat. #AP50982PU-N) western blot analysis in U251 cell line lysates (35µg/lane).This demonstrates the CMKOR1 antibody detected the CMKOR1 protein (arrow). Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CXCR7 / GPR159 antibody

Immunofluorescence analysis of COS7 cells, using CXCR7 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

CXCR7 / GPR159 antibody

Immunofluorescence analysis of COS7 cells, using CXCR7 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

CXCR7 / GPR159 antibody

Immunohistochemical analysis of GPR159 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CXCR7 / GPR159 antibody

Immunohistochemical analysis of GPR159 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CXCR7 / GPR159 antibody

Immunohistochemical analysis of GPR159 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CXCR7 / GPR159

CXCR7 / GPR159 Human
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ACKR3 overexpression lysate

ACKR3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CXCR7 (mGFP-tagged)-Human chemokine (C-X-C motif) receptor 7 (CXCR7), 200 uL, >10^7 TU/mL

Lenti ORF particles, CXCR7 (mGFP-tagged)-Human chemokine (C-X-C motif) receptor 7 (CXCR7), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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