CXXC4 antibody

Principal name

CXXC4 antibody

Alternative names for CXXC4 antibody

IDAX, CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein

SwissProt ID

Q6NXI8 (Mouse), Q9EQC9 (Rat), Q9H2H0 (Human)

Gene ID

80319 (CXXC4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CXXC4 antibody

CXXC4 Antibody: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt sigling pathway, through its C-termil region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt sigling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.

General readings

Kojima, T., et al. Oncogene 28(2):297-305 (2009)
Hino, S., et al. Mol. Cell. Biol. 21(1):330-342 (2001)

  1. Quick-Filters:
  2. Cited (1)
  3. Highly Validated (1)

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CXXC4 control peptide

Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
50 µg / €160.00
  Acris Antibodies GmbH

CXXC4 (C-term) antibody

Formalin-fixed, paraffin-embedded human colon carcinoma reacted with CXXC4 antibody Cat.-No. AP51153PU-N (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CXXC4 (N-term) antibody

Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXXC4 antibody

WB Suggested Anti-CXXC4 Antibody; Titration: 1.0 ug/ml; Positive Control: MCF7 Whole Cell Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CXXC4 (C-term) antibody

AP32075PU-N CXXC4 Antibody staining of paraffin embedded Human Breast at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu, Ms E, P
0.1 mg / €340.00
  Acris Antibodies GmbH

CXXC4 antibody

Western Blot: CXXC4 Antibody [NBP1-76491] - Analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

CXXC4 antibody

Immunohistochemistry-Paraffin: CXXC4 Antibody [NBP1-81613] Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CXXC4

CXXC4 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CXXC4

CXXC4 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

9 Item(s)

per page
  • LinkedIn