CXXC4 antibody

Principal name

CXXC4 antibody

Alternative names for CXXC4 antibody

IDAX, CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein

SwissProt ID

Q6NXI8 (Mouse), Q9EQC9 (Rat), Q9H2H0 (Human)

Gene ID

80319 (CXXC4), 319478 (Cxxc4), 83824

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of CXXC4 antibody

CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.

General readings

Kojima, T., et al. Oncogene 28(2):297-305 (2009)
Hino, S., et al. Mol. Cell. Biol. 21(1):330-342 (2001)

  1. Quick-Filters:
  2. Highly Validated (1)

20 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CXXC4 (C-term) antibody

Formalin-fixed, paraffin-embedded human colon carcinoma reacted with CXXC4 antibody Cat.-No. AP51153PU-N (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CXXC4 (N-term) antibody

  Rabbit Polyclonal CXXC4 Antibody  
Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CXXC4 antibody

  Rabbit Polyclonal Anti-CXXC4 Antibody  
WB Suggested Anti-CXXC4 Antibody; Titration: 1.0 ug/ml; Positive Control: MCF7 Whole Cell Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CXXC4 (C-term) antibody

AP32075PU-N CXXC4 Antibody staining of paraffin embedded Human Breast at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu, Ms E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CXXC4 - human gene knockout kit via CRISPR

CXXC4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CXXC4 - human gene knockout kit via CRISPR

CXXC4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CXXC4 - human gene knockout kit via CRISPR

CXXC4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CXXC4 - human gene knockout kit via CRISPR

CXXC4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cxxc4 - mouse gene knockout kit via CRISPR

Cxxc4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cxxc4 - mouse gene knockout kit via CRISPR

Cxxc4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cxxc4 - mouse gene knockout kit via CRISPR

Cxxc4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cxxc4 - mouse gene knockout kit via CRISPR

Cxxc4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CXXC4 (mGFP-tagged) - Human CXXC finger protein 4 (CXXC4), 200 uL, >10^7 TU/mL

Lenti ORF particles, CXXC4 (mGFP-tagged) - Human CXXC finger protein 4 (CXXC4), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, CXXC4 (Myc-DDK tagged) - Human CXXC finger protein 4 (CXXC4) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CXXC4 (Myc-DDK tagged) - Human CXXC finger protein 4 (CXXC4) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cxxc4 (GFP-tagged) - Mouse CXXC finger 4 (cDNA clone MGC:86040 IMAGE:30619087), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cxxc4 (GFP-tagged) - Mouse CXXC finger 4 (cDNA clone MGC:86040 IMAGE:30619087), 200 uL, >10^7 TU/mL  
200 µl / €790.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cxxc4 (GFP-tagged) - Mouse CXXC finger 4 (Cxxc4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cxxc4 (GFP-tagged) - Mouse CXXC finger 4 (Cxxc4), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cxxc4 (Myc-DDK-tagged) - Mouse CXXC finger 4 (cDNA clone MGC:86040 IMAGE:30619087), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cxxc4 (Myc-DDK-tagged) - Mouse CXXC finger 4 (cDNA clone MGC:86040 IMAGE:30619087), 200 uL, >10^7 TU/mL  
200 µl / €700.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cxxc4 (Myc-DDK-tagged) - Mouse CXXC finger 4 (Cxxc4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cxxc4 (Myc-DDK-tagged) - Mouse CXXC finger 4 (Cxxc4), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cxxc4 (GFP-tagged ORF) - Rat CXXC finger 4 (Cxxc4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cxxc4 (GFP-tagged ORF) - Rat CXXC finger 4 (Cxxc4), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cxxc4 (Myc-DDK-tagged ORF) - Rat CXXC finger 4 (Cxxc4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cxxc4 (Myc-DDK-tagged ORF) - Rat CXXC finger 4 (Cxxc4), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

20 Item(s)

per page
  • LinkedIn