Cyclin D1 antibody

Principal name

Cyclin D1 antibody

Alternative names for Cyclin D1 antibody

Cyclin-D1, PRAD-1 oncogene, BCL-1 oncogene, CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1

SwissProt ID

P24385 (Human), P25322 (Mouse), P39948 (Rat), P50755 (Xenla), P55169 (Chick), Q2KI22 (Bovin), Q5R6J5, Q64HP0, Q90459

Gene ID

595 (CCND1), 12443 (Ccnd1), 58919

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Chk (Chicken), Frog, Bov (Bovine), Can (Canine), Dros (Drosophila), Rb (Rabbit), African clawed frog, Ze (Zebrafish), Mky (Monkey), Sh (Sheep)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of Cyclin D1 antibody

D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. CyclinD1(CCND1), also known as BCL1. Expression of cyclin D1, but not of cyclins A and E, was induced by transfection of the RB gene into RB-deficient tumor cells. cyclin D1 gene can function as an oncogene. Cyclin D1 expression is regulated by the retinoblastoma protein.
The protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis. Brisken et al. (2003) found that prolactin (PRL; 176760) induced IGF2 (147470) mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures. And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin, IGF2, and cyclin D1 are components of a developmental pathway in mammary gland.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cyclin D1 antibody

Western blot analysis of Cyclin D1 Antibody Cat.-No AP20500PU-N in extracts from K562 cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cyclin D1 antibody

  Rabbit Monoclonal anti-Cyclin D1 Antibody  
Western Blot analysis of MCF7 cell lysate with cyclin D1 anitbody Rabbit IgG SP4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cyclin D1 antibody

Immunohistochemical detection of Cyclin D1 on paraffin embeddedsection of Human Mantle Cell Lymphoma with AM26674AF-N. Mouse IgG2a 5D4 Azide Free Hu, Ms F, IP, P, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Cyclin D1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human mantle cell lymphoma –lymph node tissue (4 µm) stained with anti-Cyclin D1 antibody (DB 066) shows strong positive nuclear immunostaining of tumor cells.
Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG E16-I Aff - Purified Hu C, P
0.1 ml / €310.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cyclin D1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human mantle cell lymphoma –lymph node tissue (4 µm) stained with anti-Cyclin D1 antibody (DB 066) shows strong positive nuclear immunostaining of tumor cells.
Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG E16-I Aff - Purified Hu C, P
0.2 ml / €420.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cyclin D1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human mantle cell lymphoma –lymph node tissue (4 µm) stained with anti-Cyclin D1 antibody (DB 066) shows strong positive nuclear immunostaining of tumor cells.
Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG E16-I Aff - Purified Hu C, P
0.5 ml / €540.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cyclin D1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human mantle cell lymphoma –lymph node tissue (4 µm) stained with anti-Cyclin D1 antibody (DB 066) shows strong positive nuclear immunostaining of tumor cells.
Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG E16-I Aff - Purified Hu C, P
1 ml / €840.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cyclin D1 antibody

Western blot analysis of Cyclin D1 in 1) C2C12, 2) HepG2, and 3) NIH3T3 lysate using Cyclin D1 Antibody (Clone DCS-6). Mouse IgG2a DCS-6 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Western blot analysis of Cyclin D1 in 1) C2C12, 2) HepG2, and 3) NIH3T3 lysate using Cyclin D1 Antibody (Clone DCS-6). Mouse IgG2a DCS-6 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Western blot analysis of Cyclin D1 in 1) C2C12, 2) HepG2, and 3) NIH3T3 lysate using Cyclin D1 Antibody (Clone DCS-6). Mouse IgG2a DCS-6 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Formalin-paraffin human mantle cell lymphoma stained with Cyclin D1 Antibody Cat.-No AM50162PU (Clone SPM587).  Note nuclear staining of tumor cells. Mouse IgG2a SPM587 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Formalin-paraffin human mantle cell lymphoma stained with Cyclin D1 Antibody Cat.-No AM50162PU (Clone SPM587).  Note nuclear staining of tumor cells. Mouse IgG2a SPM587 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Formalin-paraffin human mantle cell lymphoma stained with Cyclin D1 Antibody Cat.-No AM50162PU (Clone SPM587).  Note nuclear staining of tumor cells. Mouse IgG2a SPM587 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

Cyclin D1 antibody

  Rabbit polyclonal Cyclin D1 antibody  
WB analysis using anti-Cyclin D1 antibody to detect Human Cyclin D1 present in asynchronous HN30 cell lysates. HN30 cells, are from head and neck cancer cells that over express cyclin B1 and D1. Comparison to a molecular weight marker indicates a band of ~34 kDa corresponding to the expected molecular weight for the protein (arrowhead). The blot was incubated with a 1:500 dilution of the antibody at room temperature. Rabbit Serum Hu, Ms, Rt E, WB
0.1 ml / €356.00
  OriGene Technologies, Inc.

Cyclin D1 antibody

  Anti-CCND1 Rabbit Polyclonal Antibody  
Predicted band size: 34 kDa . Positive control: A549 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cyclin D1 antibody

  Anti-CCND1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Nucleus . Positive control: Human breast and thyroid cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CCND1 antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cyclin D1 antibody

  Rabbit polyclonal CCND1 Antibody (C-term T288)  
CCND1 Antibody (T288) (Cat. #TA324687) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CCND1 antibody detected the CCND1 protein (arrow). Rabbit IgG Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Cyclin D1 antibody

  Rabbit Polyclonal Cyclin D1 Antibody  
Western blot analysis of Cyclin D1 expression in K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cyclin D1 antibody

  Rabbit Polyclonal Cyclin D1 Antibody  
Western blot analysis of extracts from Jurkat cells, using Cyclin D1 Antibody.. The lane on the left is treated with the synthesized peptide. Rabbit IgG Purified Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cyclin D1 antibody

  Rabbit Polyclonal Cyclin D1 (Ser90) Antibody (Phospho-specific)  
Western blot analysis of Cyclin D1 phosphorylation expression in K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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