Cyclin D1 antibody

Principal name

Cyclin D1 antibody

Alternative names for Cyclin D1 antibody

Cyclin-D1, PRAD-1 oncogene, BCL-1 oncogene, CCND1, BCL1, PRAD1, G1/S-specific cyclin-D1

SwissProt ID

P24385 (Human), P25322 (Mouse), P39948 (Rat), P50755 (Xenla), P55169 (Chick), Q2KI22 (Bovin), Q5R6J5, Q64HP0, Q90459

Gene ID

595 (CCND1), 58919 (Ccnd1), 12443, 30222 (ccnd1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Chimp (Chimpanzee), Chk (Chicken), Frog, Bov (Bovine), Can (Canine), Dros (Drosophila), Rb (Rabbit), African clawed frog, Ze (Zebrafish), Gt (Goat), Sh (Sheep)

Available hosts

Rabbit, Mouse, Rat, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), ELISA (detection) (E(detection))

Background of Cyclin D1 antibody

D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. CyclinD1(CCND1), also known as BCL1. Expression of cyclin D1, but not of cyclins A and E, was induced by transfection of the RB gene into RB-deficient tumor cells. cyclin D1 gene can function as an oncogene. Cyclin D1 expression is regulated by the retinoblastoma protein.
The protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer. The cyclin D1 gene is overexpressed in human breast cancers and is required for oncogene-induced tumorigenesis. Brisken et al. (2003) found that prolactin (PRL; 176760) induced IGF2 (147470) mRNA and IGF2 induced cyclin D1 protein expression in mouse mammary epithelial cultures. And they also concluded that IGF2 is a mediator of prolactin-induced alveologenesis and that prolactin, IGF2, and cyclin D1 are components of a developmental pathway in mammary gland.

General readings

Xiong Y et al. Human D-type cyclin. Cell 65:691-9 (1991). PubMed PMID: 1827756
Motokura T et al. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350:512-5 (1991). PubMed PMID: 1826542

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cyclin D1 antibody

Western blot analysis of Cyclin D1 Antibody Cat.-No AP20500PU-N in extracts from K562 cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Immunohistochemical detection of Cyclin D1 on paraffin embeddedsection of Human Mantle Cell Lymphoma with AM26674AF-N. Mouse IgG2a 5D4 Azide Free Hu, Ms F, IP, P, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Immunohistochemistry: Cyclin D1 Antibody (EP272Y) [NB110-56901] - Immunohistochemical analysis of paraffin-embedded human kidney carcinoma using anti-Cyclin D1. Rabbit IgG EP272Y Aff - Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Cyclin D1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human mantle cell lymphoma –lymph node tissue (4 µm) stained with anti-Cyclin D1 antibody (DB 066) shows strong positive nuclear immunostaining of tumor cells.
Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG E16-I Aff - Purified Hu C, P
0.1 ml / €310.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cyclin D1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human mantle cell lymphoma –lymph node tissue (4 µm) stained with anti-Cyclin D1 antibody (DB 066) shows strong positive nuclear immunostaining of tumor cells.
Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG E16-I Aff - Purified Hu C, P
0.2 ml / €420.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cyclin D1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human mantle cell lymphoma –lymph node tissue (4 µm) stained with anti-Cyclin D1 antibody (DB 066) shows strong positive nuclear immunostaining of tumor cells.
Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG E16-I Aff - Purified Hu C, P
0.5 ml / €540.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cyclin D1 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human mantle cell lymphoma –lymph node tissue (4 µm) stained with anti-Cyclin D1 antibody (DB 066) shows strong positive nuclear immunostaining of tumor cells.
Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG E16-I Aff - Purified Hu C, P
1 ml / €840.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cyclin D1 (C-term) antibody

AM11128PU Cyclin D1 antibody satining of Human mantle cell lymphoma. Rabbit SP4 Supernatant Hu, Ms, Rt P, WB
0.5 ml / €520.00
  Acris Antibodies GmbH

Cyclin D1 (C-term) antibody

AM11128PU Cyclin D1 antibody satining of Human mantle cell lymphoma. Rabbit SP4 Supernatant Hu, Ms, Rt P, WB
1 ml / €720.00
  Acris Antibodies GmbH

Cyclin D1 (C-term) antibody

AM11128PU Cyclin D1 antibody satining of Human mantle cell lymphoma. Rabbit SP4 Supernatant Hu, Ms, Rt P, WB
0.1 ml / €290.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Western blot analysis of Cyclin D1 in 1) C2C12, 2) HepG2, and 3) NIH3T3 lysate using Cyclin D1 Antibody (Clone DCS-6). Mouse IgG2a DCS-6 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Western blot analysis of Cyclin D1 in 1) C2C12, 2) HepG2, and 3) NIH3T3 lysate using Cyclin D1 Antibody (Clone DCS-6). Mouse IgG2a DCS-6 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Western blot analysis of Cyclin D1 in 1) C2C12, 2) HepG2, and 3) NIH3T3 lysate using Cyclin D1 Antibody (Clone DCS-6). Mouse IgG2a DCS-6 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Formalin-paraffin human mantle cell lymphoma stained with Cyclin D1 Antibody Cat.-No AM50162PU (Clone SPM587).  Note nuclear staining of tumor cells. Mouse IgG2a SPM587 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Formalin-paraffin human mantle cell lymphoma stained with Cyclin D1 Antibody Cat.-No AM50162PU (Clone SPM587).  Note nuclear staining of tumor cells. Mouse IgG2a SPM587 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cyclin D1 antibody

Formalin-paraffin human mantle cell lymphoma stained with Cyclin D1 Antibody Cat.-No AM50162PU (Clone SPM587).  Note nuclear staining of tumor cells. Mouse IgG2a SPM587 Purified Hu, Mky, Ms, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Cyclin D1 antibody

AP15511PU Cyclin-D1 antibody staining of Human Mantle Cell Lymphoma. Rabbit Purified Hu, Ms, Rt P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

Cyclin D1 antibody

AP15511PU Cyclin-D1 antibody staining of Human Mantle Cell Lymphoma. Rabbit Purified Hu, Ms, Rt P, WB
1 ml / €440.00
  Acris Antibodies GmbH

Cyclin D1 antibody

AP15511PU Cyclin-D1 antibody staining of Human Mantle Cell Lymphoma. Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

Cyclin D1 antibody

WB analysis using anti-Cyclin D1 antibody to detect Human Cyclin D1 present in asynchronous HN30 cell lysates. HN30 cells, are from head and neck cancer cells that over express cyclin B1 and D1. Comparison to a molecular weight marker indicates a band of ~34 kDa corresponding to the expected molecular weight for the protein (arrowhead). The blot was incubated with a 1:500 dilution of the antibody at room temperature. Rabbit Serum Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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