Cyclin T1 antibody

Principal name

Cyclin T1 antibody

Alternative names for Cyclin T1 antibody

Cyclin-T1, Cyclin-T, CycT1, CCNT1

SwissProt ID

O60563 (Human), Q6T8E9 (Bovin), Q9QWV9 (Mouse)

Gene ID

904 (CCNT1), 12455 (Ccnt1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Ze (Zebrafish), African clawed frog

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C)

Background of Cyclin T1 antibody

CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Bagella, L., MacLachlan, T.K., Buono, R.J., Pisano, M.M., Giordano, A. and De Luca, A. (1998) Cloning of murine cdk9/PITALRE and its tissue-specific expression in development.
J. Cell Physiol. 177(2):206-13.
MacLachlan, T.K., Sang, N., De Luca, A.., Puri, P.L., Levrero, M. and Giordano, A. and (1998) Binding of cdk9 to TRAF2. J. Cell Biochem. 71(4):467-478.
Peng, J., Zhu, Y., Milton, J.T. and Price, D.H. (1998). Identification of multiple cyclin subunits of human P-TEFb. Genes Dev. 12(5):755-762.
De Falco, G. and Giordano, A. (1998) CDK( (PITALRE): A Multifunctional cdc-2-related Kinase.
J. Cell. Physiol. 177; 501-506.
Zhou, Q., Chen, D., Pierstorff, E and Luo, K. (1998) Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages.
EMBO J. 17(13):3681-3691.
Fujinaga, K., Cujec, T.P., Peng, J., Garriga, J., Price, D.H., Graña, X. and Peterlin, B.M. (1998) The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1 and Tat.
J. Virol. 72(9) 7154-7159.

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cyclin T1 antibody

  Rabbit polyclonal Cyclin T1 antibody  
Amino acids are numbered on the bottom of each protein. The cyclin box is indicated. Human cyclins T2a and T2b have 642 amino acids in common but different carboxyl termini (black boxes). Rabbit Serum Hu, Ms, Rt C, E, IP, P, WB
0.1 ml / €356.00
  OriGene Technologies, Inc.

Cyclin T1 antibody

  Rabbit Polyclonal CCNT1 Antibody  
Western blot analysis of CCNT1 in rat brain tissue lysate with CCNT1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cyclin T1 antibody

  Rabbit Polyclonal Anti-CCNT1 Antibody  
WB Suggested Anti-CCNT1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: 721_B cell lysateCCNT1 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cyclin T1 antibody

  Rabbit Polyclonal Anti-CCNT1 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (CCNT1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cyclin T1 antibody

Skin: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Hu E, IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Cyclin T1 (Center) antibody

CCNT1 Antibody (Center) (Cat. #AP50822PU-N) western blot analysis in mouse testis tissue lysates (35µg/lane).This demonstrates the CCNT1 antibody detected the CCNT1 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CCNT1 - human gene knockout kit via CRISPR

CCNT1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CCNT1 - human gene knockout kit via CRISPR

CCNT1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CCNT1 - human gene knockout kit via CRISPR

CCNT1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CCNT1 - human gene knockout kit via CRISPR

CCNT1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CCNT1 (mGFP-tagged)-Human cyclin T1 (CCNT1), 200 uL, >10^7 TU/mL

Lenti ORF particles, CCNT1 (mGFP-tagged)-Human cyclin T1 (CCNT1), 200 uL, >10^7 TU/mL  
200 µl / €1,610.00
  OriGene Technologies, Inc.

Lenti ORF particles, CCNT1 (Myc-DDK-tagged)-Human cyclin T1 (CCNT1), 200 uL, >10^7 TU/mL

Lenti ORF particles, CCNT1 (Myc-DDK-tagged)-Human cyclin T1 (CCNT1), 200 uL, >10^7 TU/mL  
200 µl / €1,450.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ccnt1 (GFP-tagged) - Mouse cyclin T1 (Ccnt1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ccnt1 (GFP-tagged) - Mouse cyclin T1 (Ccnt1), 200 uL, >10^7 TU/mL  
200 µl / €1,410.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ccnt1 (Myc-DDK-tagged) - Mouse cyclin T1 (Ccnt1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ccnt1 (Myc-DDK-tagged) - Mouse cyclin T1 (Ccnt1), 200 uL, >10^7 TU/mL  
200 µl / €1,270.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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