Cyclophilin-40 antibody

Principal name

Cyclophilin-40 antibody

Alternative names for Cyclophilin-40 antibody

PPIase D, Rotamase D, Cyclophilin-related protein, PPID, CYP40, CYPD, Cyclophilin D, CYP-40, 40 kDa peptidyl-prolyl cis-trans isomerase

SwissProt ID

P26882 (Bovin), Q08752 (Human), Q6DGG0 (Rat), Q9CR16 (Mouse)

Gene ID

5481 (PPID), 67738 (Ppid), 361967

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Por (Porcine), Rb (Rabbit)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of Cyclophilin-40 antibody

Cyclophilin 40 is a widely expressed member of the cyclophilin type PPIase family, PPIase D subfamily. It contains 1 PPIase cyclophilin type domain and 3 TPR repeats. It catalyzes the cis trans isomerization of proline imidic peptide bonds in oligopeptides. and has a role in accelerating the folding of proteins. It is less sensitive to inhibition by cyclosporin A than CYP18.
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents: cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP).
Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
CyP-40, a 40 kDa protein, shares significant homology with smaller CyPA (CyP-18) and FKBP59. CyP-40 exhibits the characteristic CsA binding and isomerase activity of CyP-18, though these activities appear to be less with CyP-40 than with Cyp-18. Like FKBP59, CyP-40 has been found in progesterone receptor complexes. CyP-40 is expressed at similar levels in many tissues.

General readings

Machida K., et al.(2006) J. Biol. Chem. 281(20):14314-20.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cyclophilin-40 antibody

  Goat Polyclonal Antibody against PPID / CyP-40  
TA302580 (0.1µg/ml) staining of Human Brain (Frontal Cortex) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cyclophilin-40 antibody

  Rabbit polyclonal Anti-PPID Antibody  
WB Suggested Anti-PPID Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: NCI-H226 cell lysate Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cyclophilin-40 antibody

  Rabbit polyclonal Anti-PPID Antibody  
Host:Rabbit; Target Name:PPID; Sample Tissue:Human Jurkat; Antibody Dilution: 1.0 ug/mlPPID is strongly supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cyclophilin-40 (N-term) antibody

Western blot analysis of PPID Antibody (N-term) (AP18156PU-N) in NIH-3T3 cell line lysates (35ug/lane). PPID (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PPID - human gene knockout kit via CRISPR

PPID - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PPID - human gene knockout kit via CRISPR

PPID - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PPID - human gene knockout kit via CRISPR

PPID - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PPID - human gene knockout kit via CRISPR

PPID - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ppid - mouse gene knockout kit via CRISPR

Ppid - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ppid - mouse gene knockout kit via CRISPR

Ppid - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ppid - mouse gene knockout kit via CRISPR

Ppid - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ppid - mouse gene knockout kit via CRISPR

Ppid - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cyclophilin-40

  Recombinant protein of human peptidylprolyl isomerase D (PPID)  
Cyclophilin-40 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Cyclophilin-40 (1-370, His-tag)

Cyclophilin-40 Human Purified by SDS-PAGE E. coli
0.5 mg / €1,000.00
  Acris Antibodies GmbH

Cyclophilin-40 (1-370, His-tag)

Cyclophilin-40 Human Purified by SDS-PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ppid (GFP-tagged ORF) - Rat peptidylprolyl isomerase D (cyclophilin D) (Ppid), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ppid (GFP-tagged ORF) - Rat peptidylprolyl isomerase D (cyclophilin D) (Ppid), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ppid (Myc-DDK-tagged ORF) - Rat peptidylprolyl isomerase D (cyclophilin D) (Ppid), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ppid (Myc-DDK-tagged ORF) - Rat peptidylprolyl isomerase D (cyclophilin D) (Ppid), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

17 Item(s)

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