Cyclophilin-40 antibody

Principal name

Cyclophilin-40 antibody

Alternative names for Cyclophilin-40 antibody

PPIase D, Rotamase D, Cyclophilin-related protein, PPID, CYP40, CYPD, Cyclophilin D, CYP-40, 40 kDa peptidyl-prolyl cis-trans isomerase

SwissProt ID

P26882 (Bovin), Q08752 (Human), Q6DGG0 (Rat), Q9CR16 (Mouse)

Gene ID

5481 (PPID), 67738 (Ppid), 361967

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Por (Porcine), Rb (Rabbit)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of Cyclophilin-40 antibody

Cyclophilin 40 is a widely expressed member of the cyclophilin type PPIase family, PPIase D subfamily. It contains 1 PPIase cyclophilin type domain and 3 TPR repeats. It catalyzes the cis trans isomerization of proline imidic peptide bonds in oligopeptides. and has a role in accelerating the folding of proteins. It is less sensitive to inhibition by cyclosporin A than CYP18.
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents: cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP).
Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
CyP-40, a 40 kDa protein, shares significant homology with smaller CyPA (CyP-18) and FKBP59. CyP-40 exhibits the characteristic CsA binding and isomerase activity of CyP-18, though these activities appear to be less with CyP-40 than with Cyp-18. Like FKBP59, CyP-40 has been found in progesterone receptor complexes. CyP-40 is expressed at similar levels in many tissues.

General readings

Machida K., et al.(2006) J. Biol. Chem. 281(20):14314-20.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cyclophilin-40 antibody

TA302580 (0.1µg/ml) staining of Human Brain (Frontal Cortex) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cyclophilin-40 antibody

WB Suggested Anti-PPID Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: NCI-H226 cell lysate Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cyclophilin-40 antibody

Host:Rabbit; Target Name:PPID; Sample Tissue:Human Jurkat; Antibody Dilution: 1.0 ug/mlPPID is strongly supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cyclophilin-40 (N-term) antibody

Western blot analysis of PPID Antibody (N-term) (AP18156PU-N) in NIH-3T3 cell line lysates (35ug/lane). PPID (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Cyclophilin-40 antibody

Cyclophilin-40 Mouse Purified Hu, Ms, Rt E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Cyclophilin-40 antibody

Cyclophilin-40 Mouse Purified Hu, Rt E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Cyclophilin-40 antibody

Immunoprecipitation of PPID transfected lysate using anti-PPID MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with PPID MaxPab mouse polyclonal antibody (B01) (H00005481-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

Cyclophilin-40 antibody

Western Blot analysis of PPID expression in transfected 293T cell line (H00005481-T02) by PPID MaxPab polyclonal antibody.

Lane 1: PPID transfected lysate(40.80 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Cyclophilin-40 antibody

Cyclophilin-40 Mouse IgG2a 4C7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Cyclophilin-40 antibody

293 overexpressing PPID and probed with PPID polyclonal antibody ( Cat # PAB7312 ) ( mock transfection in first lane), tested by Origene. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Cyclophilin-40 antibody

Human NCI-H226; WB Suggested Anti-PPID Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: NCI-H226 cell lysate; PPID antibody - N-terminal region (ARP56624_P050) in Human NCI-H226 cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Cyclophilin-40 antibody

Human 293T; Host:Rabbit. Target Name:PPID. Sample Tissue:Human 293T. Antibody Dilution: 1.0ug/ml.; PPID antibody - middle region (ARP56625_P050) in Human 293T cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Cyclophilin-40 antibody

Cyclophilin-40 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cyclophilin-40

Cyclophilin-40 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Cyclophilin-40 (1-370, His-tag)

Cyclophilin-40 Human Purified by SDS-PAGE E. coli
0.5 mg / €1,000.00
  Acris Antibodies GmbH

Cyclophilin-40 (1-370, His-tag)

Cyclophilin-40 Human Purified by SDS-PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

Cyclophilin-40

Cyclophilin-40 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Cyclophilin-40

Cyclophilin-40 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Cyclophilin-40

Cyclophilin-40 Human
0.1 mg / €450.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

PPID (Human) IP-WB Antibody Pair

PPID (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

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