CYLD antibody

Principal name

CYLD antibody

Alternative names for CYLD antibody

CYLD, CYLD1, KIAA0849, Ubiquitin carboxyl-terminal hydrolase CYLD, EC=3.1.2.15, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD, Deubiquitinating enzyme CYLD

SwissProt ID

Q1RMU2 (Bovin), Q66H62 (Rat), Q80TQ2 (Mouse), Q9NQC7 (Human)

Gene ID

1540 (CYLD), 74256 (Cyld)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chimp (Chimpanzee), Mky (Monkey), Prim (Primate)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of CYLD antibody

CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.

General readings

Massoumi R, Chmielarska K, Hennecke K, Pfeifer A, Fassler R. Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell. 2006 May 19;125(4):665-77. PMID: 16713561

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CYLD antibody

TA303213 (0.5µg/ml) staining of rat brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CYLD antibody

Detection of CYLD in Jurkat whole cell extract using anti-CYLD. Rabbit Purified Bov, Hu, Ms, Prim WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CYLD antibody

Western Blot: CYLD Antibody [TA336362] - analysis of CYLD in HeLa cell lysate using this antibody. Rabbit Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CYLD antibody

CYLD Mouse IgG2a 2C3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CYLD antibody

CYLD Mouse IgG2b 3A9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CYLD antibody

CYLD Mouse IgG2a 2G1 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CYLD antibody

CYLD Mouse IgG2a 1E9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CYLD antibody

CYLD Mouse IgG2a 2F9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CYLD antibody

ICC staining of HeLa cell using control ( rabbit Ig ) at 5 µg/ml. Rabbit Bov, Chimp, Hu, Ms ICC/IF, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CYLD antibody

The Cyld polyclonal antibody ( Cat # PAB7243 ) ( 0.5 µg/ml ) staining of rat brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Ms, Rt E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CYLD antibody

Western blot analysis of CYLD in Jurkat whole cell extract using CYLD polyclonal antibody ( Cat # PAB12454 ). Rabbit Bov, Hu, Ms WB
0.1 ml / €410.00
  Abnova Taiwan Corp.

CYLD antibody

Western Blot: Cyld Antibody [NB100-58966] - NB100-58966 (0.5ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Ms, Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

CYLD antibody

CYLD Rabbit Aff - Purified Bov, Hu, Mky, Ms WB
25 µl / €160.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CYLD (transcript variant 2)

CYLD Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

CYLD (transcript variant 3)

CYLD Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

CYLD (transcript variant 1)

CYLD Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CYLD

CYLD Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CYLD

CYLD Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

18 Item(s)

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