Alternative names for CYP2C11 antibody
Cytochrome P450 2C11, CYPIIC11, Cytochrome P450H, Cytochrome P450-UT-A
Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of CYP2C11 antibody
The cytochrome P450 (P450) family of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as NADPH and P450 reductase. There are over 200 cDNA's which encode P450 protein. Epoxygenases are those P450 proteins which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450 proteins which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE).
EET's, which exhibit vasodilation activity, are formed when an epoxide group is inserted between the unsaturated carbons of AA in positions 5,6; 8,9; 11,12; 14,15. EET's are produced in cerebral cortical tissue, coronary arteries and vascular endothelium. EET's are converted from AA by the 2C11 family of P450's whose expression is induced by testosterone and is therefore not generally found in females.
This product has been used in:Alkayed NJ et al. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke 27:971-9 (1996). PubMed PMID: 8623121