Alternative names for CYP4A10 antibody
Cytochrome P450 4A10, CYPIVA10, Cyp4a-1, Cyp4a1, Cytochrome P452, Lauric acid omega-hydroxylase, Cytochrome P450-LA-omega 1
Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of CYP4A10 antibody
The cytochrome P450 (P450) family of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as NADPH and P450 reductase. There are over 200 cDNA's which encode P450 protein. Epoxygenases are those P450 proteins which metabolize AA to epoxyeicosatrienoic acid (EETs) and w-hydroxylases are those P450 proteins which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). 20-HETE is converted from AA by the 4A family of P450 proteins which includes at least 8 different, though closely related isoforms. 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels.
This product has been used in:Harder DR et al. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J Vasc Res 32:79-92 (1995). PubMed PMID: 7537544
Ma YH et al. Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. Am J Physiol 267:R579-89 (1994). PubMed PMID: 8067471