Cystatin-B antibody

Principal name

Cystatin-B antibody

Alternative names for Cystatin-B antibody

Stefin-B, CPI-B, CSTB, CST6, STFB, Liver thiol proteinase inhibitor

SwissProt ID

P01041 (Rat), P04080 (Human), P25417 (Bovin), Q10994 (Sheep), Q29290 (Pig), Q62426 (Mouse)

Gene ID

1476 (CSTB), 13014 (Cstb)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Por (Porcine), Rb (Rabbit), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Sh (Sheep)

Available hosts

Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), EPair for Elisa (EPair), ELISA (detection) (E(detection))

Background of Cystatin-B antibody

CSTB is a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in CSTB gene are responsible for the primary defects in patients with progressive myoclonic epilepsy a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy.The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).

General readings

Turk V, et al (1991) FEBS Lett. 285 (2): 213-9. Jarvinen M, et al, (1988) Acta Histochem. 82 (1): 5-18.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cystatin-B antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 M2-F1 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Cystatin-B antibody

  Goat Anti-Cystatin B / Stefin B Antibody  
(0.1ug/ml) staining of Human Lungs (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cystatin-B antibody

  Rabbit polyclonal anti-Stefin B antibody  
Western blot analysis of extracts from A549 cells, using Stefin B antibody (#TA313376).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cystatin-B antibody

  Rabbit Polyclonal Anti-CSTB Antibody  
CSTB antibody - middle region validated by WB using Transfected 293T cell lysate at 0.25 ug/ml. Rabbit IgG Purified Can, Eq, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cystatin-B antibody

  Rabbit Polyclonal Anti-CSTB Antibody  
WB Suggested Anti-CSTB Antibody Titration: 0.25 ug/ml; Positive Control: 293T cells lysate Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cystatin-B antibody

  Rabbit Polyclonal Anti-CSTB Antibody  
Western blot analysis on A549 cell lysate using CSTB Antibody Rabbit IgG Purified Hu, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cystatin-B antibody

  Rabbit Polyclonal Anti-CSTB Antibody  
Gel: 10+12%SDS-PAGE, Lysate: 40 ug, Lane: Mouse spleen tissue, Primary antibody: (CSTB Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2.5 minutes Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cystatin-B antibody

Western blot analysis of recombinant Human Cystatin B. Mouse IgG1 RJMW2E7 Aff - Purified Hu C, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

Cystatin-B (1-98) antibody

The Cell lysates of A549 (35ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human CSTB (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b 2F1 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Cystatin-B (1-98) antibody

The Cell lysates of A549 (35ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human CSTB (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b 2F1 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

Cystatin-B antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 M1-C1 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Cystatin-B antibody

Immunohistochemistry (IHC) analysis of Crystatin-B antibody Cat.-No AP06334PU-N in paraffin-embedded Human breast carcinoma tissue. Rabbit Aff - Purified Hu, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cystatin-B antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Stefin B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Rt E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

Cystatin-B antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Stefin B Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Rt E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CSTB - human gene knockout kit via CRISPR

CSTB - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CSTB - human gene knockout kit via CRISPR

CSTB - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cstb - mouse gene knockout kit via CRISPR

Cstb - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cstb - mouse gene knockout kit via CRISPR

Cstb - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cstb - mouse gene knockout kit via CRISPR

Cstb - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cstb - mouse gene knockout kit via CRISPR

Cstb - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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