Cytochrome b-245 light chain antibody

Principal name

Cytochrome b-245 light chain antibody

Alternative names for Cytochrome b-245 light chain antibody

CYBA, p22-phox, Cytochrome b558 subunit alpha, p22 phagocyte B-cytochrome, Neutrophil cytochrome b 22 kDa polypeptide, Cytochrome b(558) alpha chain, Superoxide-generating NADPH oxidase light chain subunit

SwissProt ID

O46521 (Bovin), P13498 (Human), P52650 (Pig), Q61462 (Mouse), Q62737 (Rat), Q95MN4 (Rabit)

Gene ID

1535 (CYBA)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine), Sh (Sheep)

Available hosts

Mouse, Rabbit

Available applications

Flow Cytometry (F), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Cytochrome b-245 light chain antibody

The integral membrane protein flavocytochrome b (Cyt b), a heterodimer formed by a 91-kD glycoprotein (heavy chain) and a 22-kD polypeptide (light chain), is the catalytic core of the phagocyte NADPH oxidase and generates superoxide which plays a critical role in host defense.  The p22phox gene encodes the light alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. p22phox is a prerequisite for TNF-induced but not for Toll-like-receptor-induced ROS production. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD) that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.
Structure: 195 amino acids with predicted molecular weight of 21 kD.
Distribution: Membrane. 
Function: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.  
Interaction: Composed of a heavy chain (beta) and a light chain (alpha). Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX3 and NOX4.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cytochrome b-245 light chain antibody

Human neutrophil extracts were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified monoclonal anti-p22phox antibody (clone 44.1). Proteins were visualized using a goat anti-mouse-IgG secondary conjugated to HRP and chemiluminescence detection. Mouse IgG2a 44.1 Purified Hu F, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cytochrome b-245 light chain antibody

WB Suggested Anti-CYBA Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Small Intestine Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cytochrome b-245 light chain antibody

Flow cytometric analysis of Flavocytochrome b558 expression on Granulocytes (1), Monocytes (2) and Lymphocytes (3). The staining intensity of AM26496AF-N is shown in the horizonal axis withCD19-FITC staining on the vertical axis. Mouse IgG1 7D5 Azide Free Hu F
0.1 mg / €360.00
  Acris Antibodies GmbH

Cytochrome b-245 light chain antibody

Flow cytometric analysis of Flavocytochrome b558 expression on Lymphocytes (1), Monocytes (2) and Granulocytes (3). Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26496FC-N to the cells. Mouse IgG1 7D5 FITC Hu F
50 µg / €410.00
  Acris Antibodies GmbH

Cytochrome b-245 light chain antibody

Flow cytometric analysis of Flavocytochrome b558 expression on Lymphocyte (1), Monocyte (2) and Granulocyte (3). The staining intensity of AM26496RP-N is shown in the vertical axis with CD19 staining on the horizontal axis. Mouse IgG1 7D5 PE Hu, Mky F
50 Tests / €390.00
  Acris Antibodies GmbH

Cytochrome b-245 light chain antibody

Human neutrophil extracts were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified monoclonal anti-p22phox antibody (clone 44.1). Proteins were visualized using a goat anti-mouse-IgG secondary conjugated to HRP and chemiluminescence detection. Mouse IgG2a 44.1 Purified Hu F, ICC/IF, P, WB
25 µg / €240.00
  Acris Antibodies GmbH

Cytochrome b-245 light chain (C-term) antibody

Confocal immunofluorescent analysis of CYBA Antibody (C-term) Cat.-No AP51159PU-N with NCI-H292 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). Rabbit Ig Aff - Purified Hu ICC/IF, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Cytochrome b-245 light chain antibody

Human Small Intestine; WB Suggested Anti-CYBA Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Small Intestine; CYBA antibody - middle region (ARP44214_P050) in Human Small Intestine cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Cytochrome b-245 light chain antibody

Western blot analysis of p22 phox expression in MCF7 (A); NIH3T3 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Cytochrome b-245 light chain antibody

Western blot analysis of p22 phox expression in MCF7 (A); NIH3T3 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Cytochrome b-245 light chain antibody

Western blot analysis of p22 phox expression in MCF7 (A); NIH3T3 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Cytochrome b-245 light chain antibody

Cytochrome b245 Light Chain Antibody [CS9] Mouse IgG1 CS9 Purified Hu C, E, F, IP, WB
0.1 ml / €400.00
  Immuquest

Cytochrome b-245 light chain antibody

Cytochrome b245 Light Chain Antibody [44.1] Mouse IgG2 44.1 Purified Hu WB
0.1 ml / €400.00
  Immuquest

Cytochrome b-245 light chain antibody

Cytochrome b-245 light chain Mouse IgG1 CS9 Purified Hu C, E, F, IP, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Cytochrome b-245 light chain antibody

Flow cytometry / FACS analysis: Cytochrome b245 alpha  Antibody (CS9) [FITC] [NBP1-41013] - Staining of human peripheral blood granulocytes with Mouse anti Human Cytochrome b-245 Light Chain:FITC. Permeabilised with Leucoperm Mouse IgG1 CS9 FITC Hu F
50 µg / €310.00
  Novus Biologicals Inc.

Cytochrome b-245 light chain antibody

Cytochrome b-245 light chain Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

16 Item(s)

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