Cytohesin 2 antibody

Principal name

Cytohesin 2 antibody

Alternative names for Cytohesin 2 antibody

PSCD2, PSCD2L, ARNO, CYTH2, PH, SEC7 and coiled-coil domain-containing protein 2, ARF nucleotide-binding site opener, ARF exchange factor

SwissProt ID

P63034 (Mouse), P63035 (Rat), Q2KI41 (Bovin), Q99418 (Human)

Gene ID

9266 (CYTH2), 19158 (Cyth2), 116692

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Can (Canine), Bov (Bovine), Por (Porcine), Sh (Sheep), Ze (Zebrafish)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of Cytohesin 2 antibody

The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins.
Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D.
Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf’s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).

General readings

Merkulova, M., et al. Biochim. Biophys. Acta 1797(8):1398-1409 (2010).
Torii, T., et al. J. Biol. Chem. 285(31):24270-24281 (2010).
White, D.T., et al. Mol. Biol. Cell 21(4):562-571 (2010).
Bouschet, T., et al. J. Cell. Sci. 120 (PT 15), 2489-2497 (2007).
Wu, C., et al. Proteomics 7(11):1775-1785 (2007).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cytohesin 2 antibody

  Rabbit Polyclonal Cytohesin 2 Antibody  
Immunohistochemistry: Cytohesin 2 Antibody - Most of the normal tissues displayed weak to moderate cytoplasmic positivity. Distinct cytoplasmic staining was seen in a fraction of cells in red pulp of spleen and distinct membranous positivity was seen in trophoblasts. Squamous epithelia, urothelia, kidney, myocytes and cells of the CNS were mainly negative. Malignant tissues were negative or showed weak cytoplasmic immunoreactivity. A single case of lymphoma exhibited strong staining. Melanomas and urothelial cancers were predominantly weakly to moderately stained.  Image and statement courtesy of the Human Protein Atlas (HPA). Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cytohesin 2 (N-term) antibody

  Goat Polyclonal Antibody against PSCD2  
TA303303 (0.5µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cytohesin 2 antibody

  Rabbit Polyclonal Anti-CYTH2 Antibody  
Host: Rabbit; Target Name: CYTH2; Sample Tissue: MDA-MB-435S Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Hu, Ms, Por, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cytohesin 2 (N-term) antibody

Western blot analysis of PSCD2 Antibody (N-term) Cat.-No AP53479PU-N in mouse kidney tissue lysates (35ug/lane). This demonstrates the PSCD2 antibody detected the PSCD2 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CYTH2 - human gene knockout kit via CRISPR

CYTH2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CYTH2 - human gene knockout kit via CRISPR

CYTH2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CYTH2 - human gene knockout kit via CRISPR

CYTH2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CYTH2 - human gene knockout kit via CRISPR

CYTH2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cyth2 - mouse gene knockout kit via CRISPR

Cyth2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cyth2 - mouse gene knockout kit via CRISPR

Cyth2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cyth2 - mouse gene knockout kit via CRISPR

Cyth2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cyth2 - mouse gene knockout kit via CRISPR

Cyth2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cytohesin 2 (transcript variant 1)

  Recombinant protein of human cytohesin 2 (CYTH2), transcript variant 1  
Cytohesin 2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Cytohesin 2 (1-399, His-tag)

Cytohesin 2 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

Cytohesin 2 (1-399, His-tag)

Cytohesin 2 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

CYTH2 overexpression lysate

CYTH2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CYTH2 (mGFP-tagged) - Human cytohesin 2 (CYTH2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, CYTH2 (mGFP-tagged) - Human cytohesin 2 (CYTH2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CYTH2 (mGFP-tagged)-Human cytohesin 2 (CYTH2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, CYTH2 (mGFP-tagged)-Human cytohesin 2 (CYTH2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CYTH2 (Myc-DDK tagged) - Human cytohesin 2 (CYTH2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, CYTH2 (Myc-DDK tagged) - Human cytohesin 2 (CYTH2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, CYTH2 (Myc-DDK-tagged)-Human cytohesin 2 (CYTH2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, CYTH2 (Myc-DDK-tagged)-Human cytohesin 2 (CYTH2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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