Cytohesin 2 antibody
Principal name
Cytohesin 2 antibody
Alternative names for Cytohesin 2 antibody
PSCD2, PSCD2L, ARNO, CYTH2, PH, SEC7 and coiled-coil domain-containing protein 2, ARF nucleotide-binding site opener, ARF exchange factor
Ncbi ID
9606, NP_059431, NP_004219, NP_004219.3, NM_017457, NP_001106171.1, NM_011181, NM_001112701, NM_053911, NM_004228
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)
Background of Cytohesin 2 antibody
The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins.
Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D.
Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf’s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).
General readings
Merkulova, M., et al. Biochim. Biophys. Acta 1797(8):1398-1409 (2010).
Torii, T., et al. J. Biol. Chem. 285(31):24270-24281 (2010).
White, D.T., et al. Mol. Biol. Cell 21(4):562-571 (2010).
Bouschet, T., et al. J. Cell. Sci. 120 (PT 15), 2489-2497 (2007).
Wu, C., et al. Proteomics 7(11):1775-1785 (2007).















- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA590845 | Cytohesin 2 antibody |
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Rabbit Polyclonal Cytohesin 2 Antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, P, WB |
0.1 mg /
€409.00
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OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA303303 | Cytohesin 2 (N-term) antibody |
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Goat Polyclonal Antibody against PSCD2 | |||||||
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Goat | Aff - Purified | Can, Hu, Ms, Rt | WB |
0.1 mg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA335544 | Cytohesin 2 antibody |
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Rabbit Polyclonal Anti-CYTH2 Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Hu, Ms, Por, Rt, Sh, Ze | WB |
50 µg /
€360.00
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OriGene Technologies, Inc. | |||||||
AP53479PU-N | Cytohesin 2 (N-term) antibody |
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Rabbit | Ig | Aff - Purified | Hu, Ms | WB |
0.4 ml /
€370.00
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Acris Antibodies GmbH |
CRISPR
Catalog No. | Species | Donor Vector | |
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KN207179 | CYTH2 - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN207179BN | CYTH2 - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN207179LP | CYTH2 - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN207179RB | CYTH2 - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN304204 | Cyth2 - mouse gene knockout kit via CRISPR |
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Mouse | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN304204BN | Cyth2 - mouse gene knockout kit via CRISPR |
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Mouse | mBFP-Neo |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN304204LP | Cyth2 - mouse gene knockout kit via CRISPR |
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Mouse | Luciferase-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN304204RB | Cyth2 - mouse gene knockout kit via CRISPR |
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Mouse | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |
Proteins & Growth Factors
Catalog No. | Species | Pres. | Purity | Source | |
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TP317980 | Cytohesin 2 (transcript variant 1) |
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Recombinant protein of human cytohesin 2 (CYTH2), transcript variant 1 | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€438.00
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OriGene Technologies, Inc. | |||||
AR50576PU-N | Cytohesin 2 (1-399, His-tag) |
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Human | Purified | > 90 % by SDS - PAGE | E. coli |
0.5 mg /
€730.00
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Acris Antibodies GmbH | |||||
AR50576PU-S | Cytohesin 2 (1-399, His-tag) |
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Human | Purified | > 90 % by SDS - PAGE | E. coli |
0.1 mg /
€300.00
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Acris Antibodies GmbH |
Lysates
Catalog No. | ||
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LY413761 | CYTH2 overexpression lysate |
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0.1 mg /
€295.00
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OriGene Technologies, Inc. |
Human Lenti ORF Particles
Catalog No. | ||
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RC217980L2V | Lenti ORF particles, CYTH2 (mGFP-tagged) - Human cytohesin 2 (CYTH2), transcript variant 1, 200 uL, >10^7 TU/mL |
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200 µl /
€1,082.00
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OriGene Technologies, Inc. | ||
RC207179L2V | Lenti ORF particles, CYTH2 (mGFP-tagged)-Human cytohesin 2 (CYTH2), transcript variant 2, 200 uL, >10^7 TU/mL |
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200 µl /
€1,082.00
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OriGene Technologies, Inc. | ||
RC217980L1V | Lenti ORF particles, CYTH2 (Myc-DDK tagged) - Human cytohesin 2 (CYTH2), transcript variant 1 , 200 uL, >10^7 TU/mL |
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200 µl /
€969.00
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OriGene Technologies, Inc. | ||
RC207179L1V | Lenti ORF particles, CYTH2 (Myc-DDK-tagged)-Human cytohesin 2 (CYTH2), transcript variant 2, 200 uL, >10^7 TU/mL |
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200 µl /
€969.00
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OriGene Technologies, Inc. | ||