Cytokeratin 14 antibody

Principal name

Cytokeratin 14 antibody

Alternative names for Cytokeratin 14 antibody

Cytokeratin-14, CK14, Keratin 14, K14, KRT14, Keratin Type I Cytoskeletal 14

SwissProt ID

P02533 (Human), P05785 (Bovin), Q61781 (Mouse), Q6IFV1 (Rat), Q6PVZ1 (Chick)

Gene ID

3861 (KRT14), 16664 (Krt14), 3690 (ITGB3), 408039

Available reactivities

Hu (Human), Can (Canine), Por (Porcine), Rt (Rat), Fe (Feline), Bov (Bovine), Ms (Mouse), Hst (Hamster), Chk (Chicken), Mky (Monkey), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Guinea Pig

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Enzyme Immunoassay (E)

Background of Cytokeratin 14 antibody

Keratin 14 is a member of the keratin family, the most diverse group of intermediate filaments. It is usually found as a heterotetramer with two molecules of keratin 5, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. Keratin 14 has been studied as a prognostic marker in breast cancer.
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9–7.8.
The individual human cytokeratins are designated 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies.
The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

General readings

1. Purkis, P.E. et al. (1990) Antibody markers of basal cells in complex epithelia. J. Cell Sci. 97: 39-50.
2. Lane, E.B. and Alexander, C.M. (1990) Use of keratin antibodies in tumor diagnosis. Semin. Canc. Biol. 1: 165-179.
3. Westzels, R.H.W. et al. (1989) Detection of basement membrane components and basal cell keratin 14 in noninvasive and invasive carcinomas of the breast. Am. J. Pathol. 134: 571-579.
4. Moll, R. et al. (1982) The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell. 31: 11-24.
5. Varley, C.L. et al. (2004) Activation of peroxisome proliferatoractivated receptorgamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells. Am J Pathol. 164: 178998.
6. Abdeen, S.K. et al. (2011) Wwox inactivation enhances mammary tumorigenesis. Oncogene. 30: 39006.
7. Matos, A.J. et al. (2006) Detection of lymph node micrometastases in malignant mammary tumours in dogs by cytokeratin immunostaining. Vet Rec. 158: 62630.
8. Turner, A. et al. (2011) Transplantation of autologous differentiated urothelium in an experimental model of composite cystoplasty. Eur Urol. 59: 44754.
8. Stumpf, P and Welsch, U. (2004) Secretory and defensive functions of the duct system of the lactating mammary gland of the African elephant (Loxodonta africana, Proboscidea)
Zoomorphology 123:155–1679. Alam, H. et al. (2011) Loss of keratins 8 and 18 leads to alterations in {alpha}6{beta}4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line. J Cell Sci. May 24. [Epub ahead of print]
10. Clark, S.E. et al. (2011) Molecular subtyping of DCIS: heterogeneity of breast cancer reflected in pre-invasive disease. Br J Cancer. 104: 120-7.
11. Hale, L.P. and Markert, M.L. (2004) Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus. J Immunol. 172: 617-24.
12. Takahashi, C. et al. (2010) Newly established cell lines from mouse oral epithelium regenerate teeth when combined with dental mesenchyme. In Vitro Cell Dev Biol Anim. 46: 457-68.
13. Faustino, A.M. et al. (2007) A salivary malignant myoepithelioma in a dog. Faustino, A.M. and Dias Pereira, P.
14. Collins, A.T. et alet al. (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 65: 10946-51.
15. Varley, C.L. et al. (2004) Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells. Am J Pathol. 164: 1789-98.
16. Abdeen, S.K. et al. (2011) Wwox inactivation enhances mammary tumorigenesis.
Oncogene. 30: 3900-6.
17. Matos, A.J. et al. (2006) Detection of lymph node micrometastases in malignant mammary tumours in dogs by cytokeratin immunostaining.
Vet Rec. 158: 626-30.
18. Turner, A. et al. (2011) Transplantation of autologous differentiated urothelium in an experimental model of composite cystoplasty. Eur Urol. 59: 447-54.
19. Munz, B. et al. (1999) Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. EMBO J. 18: 5205-15.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cytokeratin 14 antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-KRT14 mouse monoclonal antibody. (TA803267) Dilution: 1:150 Mouse IgG2a OTI4A7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 14 antibody

Immunohistochemistry-Paraffin: Cytokeratin 14 Antibody (EPR1612) [NBP1-95448] - Cytokeratin 14. Rabbit EPR1612 Purified Hu ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Cytokeratin 14 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human skin squamous cell carcinoma (A, μm), prostate hyperplasia (B, μm), and Human tonsil tissue (C, μm) stained with anti-Cytokeratin 14 antibody (DB 099) shows strong positive cytoplasmic immunostaining of the neoplastic cells (A), strong positive cytoplasmic immunostaining in the basal cells of the normal and benign glands (B), and positive cytoplasmic immunostaining of the squamous epithelial cells (C). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG D19-N Aff - Purified Hu C, P
0.1 ml / €240.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 14 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human skin squamous cell carcinoma (A, μm), prostate hyperplasia (B, μm), and Human tonsil tissue (C, μm) stained with anti-Cytokeratin 14 antibody (DB 099) shows strong positive cytoplasmic immunostaining of the neoplastic cells (A), strong positive cytoplasmic immunostaining in the basal cells of the normal and benign glands (B), and positive cytoplasmic immunostaining of the squamous epithelial cells (C). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG D19-N Aff - Purified Hu C, P
0.2 ml / €320.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 14 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human skin squamous cell carcinoma (A, μm), prostate hyperplasia (B, μm), and Human tonsil tissue (C, μm) stained with anti-Cytokeratin 14 antibody (DB 099) shows strong positive cytoplasmic immunostaining of the neoplastic cells (A), strong positive cytoplasmic immunostaining in the basal cells of the normal and benign glands (B), and positive cytoplasmic immunostaining of the squamous epithelial cells (C). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG D19-N Aff - Purified Hu C, P
0.5 ml / €400.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 14 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human skin squamous cell carcinoma (A, μm), prostate hyperplasia (B, μm), and Human tonsil tissue (C, μm) stained with anti-Cytokeratin 14 antibody (DB 099) shows strong positive cytoplasmic immunostaining of the neoplastic cells (A), strong positive cytoplasmic immunostaining in the basal cells of the normal and benign glands (B), and positive cytoplasmic immunostaining of the squamous epithelial cells (C). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG D19-N Aff - Purified Hu C, P
1 ml / €610.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 14 (C-term) antibody

Human prostate stained with anti-Cytokeratin 14 Antibody Cat.-No AM11164PU (Clone SP53). Rabbit SP53 Purified Hu F, P, WB
0.5 ml / €520.00
  Acris Antibodies GmbH

Cytokeratin 14 (C-term) antibody

Human prostate stained with anti-Cytokeratin 14 Antibody Cat.-No AM11164PU (Clone SP53). Rabbit SP53 Purified Hu F, P, WB
1 ml / €750.00
  Acris Antibodies GmbH

Cytokeratin 14 (C-term) antibody

Human prostate stained with anti-Cytokeratin 14 Antibody Cat.-No AM11164PU (Clone SP53). Rabbit SP53 Purified Hu F, P, WB
0.1 ml / €290.00
  Acris Antibodies GmbH

Cytokeratin 14 antibody

Formalin-Paraffin prostate (20X) stained with Cytokeratin 14 Antibody Cat.-No AM50130PU (Clone SPM263). Mouse IgG3 SPM263 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Cytokeratin 14 antibody

Formalin-Paraffin prostate (20X) stained with Cytokeratin 14 Antibody Cat.-No AM50130PU (Clone SPM263). Mouse IgG3 SPM263 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cytokeratin 14 antibody

Formalin-Paraffin prostate (20X) stained with Cytokeratin 14 Antibody Cat.-No AM50130PU (Clone SPM263). Mouse IgG3 SPM263 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Cytokeratin 14 antibody

Human skin stained with
anti-keratin 14 antibody Rabbit Purified Hu P, WB
0.5 ml / €300.00
  Acris Antibodies GmbH

Cytokeratin 14 antibody

Human skin stained with
anti-keratin 14 antibody Rabbit Purified Hu P, WB
1 ml / €410.00
  Acris Antibodies GmbH

Cytokeratin 14 antibody

Human skin stained with
anti-keratin 14 antibody Rabbit Purified Hu P, WB
0.1 ml / €170.00
  Acris Antibodies GmbH

Cytokeratin 14 antibody

Gel: 8%SDS-PAGE,Lysate: 20 µg,,Primary antibody: KRT14 Antibody at dilution 1/1000 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cytokeratin 14 antibody

Predicted cell location: Cytoplasm, Cell membrane . Positive control: Human cervical cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using KRT14 antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cytokeratin 14 antibody

Immunohistochemistry staining of Paraffin Squamous carcinoma tissue by Cytokeratin 14 antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic) Mouse IgG3 LL002 Purified Hu P
1 ml / €330.00
  OriGene Technologies, Inc.

Cytokeratin 14 antibody

WB Suggested Anti-KRT14 Antibody Titration: 1.25ug/ml; ELISA Titer: 1:312500; Positive Control: Human Thymus Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cytokeratin 14 antibody

Western blot analysis on NIH-3T3 cell lysate using Keratin 14 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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