Cytokeratin 17 antibody

Principal name

Cytokeratin 17 antibody

Alternative names for Cytokeratin 17 antibody

Cytokeratin-17, Keratin-17, Keratin 17, KRT17, CK17, K17, Keratin type I cytoskeletal 17

SwissProt ID

A1L595 (Bovin), Q04695 (Human), Q6IFU8 (Rat), Q9QWL7 (Mouse)

Gene ID

3872 (KRT17), 16667 (Krt17), 287702

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Gt (Goat), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Guinea Pig, Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of Cytokeratin 17 antibody

May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
Defects in KRT17 are a cause of pachyonychia congenita type 2 (PC2) [MIM:167210]; also known as pachyonychia congenita Jackson-Lawler type. PC2 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
Defects in KRT17 are a cause of steatocystoma multiplex (SM) [MIM:184500]. SM is a disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

General readings

1. Sankar S  et al. A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma. Mol Cell Biol 33:4448-60 (2013). PubMed: 24043308
2. Mardaryev AN  et al. Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle. FASEB J 24:3869-81 (2010). WB ; Mouse . PubMed: 20522784

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cytokeratin 17 antibody

Formalin fixed paraffin embedded human squamous cell carcinoma stained with Cytokeratin 17 antibody DM127 Mouse IgG2b Ks17.E3 Supernatant Hu, Rt C, P, WB
1 ml / €490.00
  Acris Antibodies GmbH

Cytokeratin 17 antibody

Formalin fixed paraffin embedded human squamous cell carcinoma stained with Cytokeratin 17 antibody DM127 Mouse IgG2b Ks17.E3 Supernatant Hu, Rt C, P, WB
0.5 ml / €330.00
  Acris Antibodies GmbH

Cytokeratin 17 antibody

Cytokeratin 17 Mouse IgG2b Ks17.E3 Purified Hu, Rt C, F, ICC/IF, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cytokeratin 17 (full length) antibody

Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 2D4-1G9 Purified Hu E, ICC/IF, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Cytokeratin 17 antibody

Immunohistochemistry-Paraffin: Cytokeratin 17 Antibody (EP1623) [NBP1-95672] - Cytokeratin 17. Rabbit EP1623 Purified Hu F, ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Cytokeratin 17 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human squamous skin carcinoma (A, 4 μm), and human breast tissue (B, 4 μm), stained with anti-Cytokeratin 17 antibody (DB 101) shows strong positive cytoplasmic immunostaining of tumor cells (A), and strong positive cytoplasmic immunostaining of myoepithelial cells in hyperplastic duct (B). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG V21-R Aff - Purified Hu C, P
0.1 ml / €240.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 17 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human squamous skin carcinoma (A, 4 μm), and human breast tissue (B, 4 μm), stained with anti-Cytokeratin 17 antibody (DB 101) shows strong positive cytoplasmic immunostaining of tumor cells (A), and strong positive cytoplasmic immunostaining of myoepithelial cells in hyperplastic duct (B). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG V21-R Aff - Purified Hu C, P
0.2 ml / €320.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 17 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human squamous skin carcinoma (A, 4 μm), and human breast tissue (B, 4 μm), stained with anti-Cytokeratin 17 antibody (DB 101) shows strong positive cytoplasmic immunostaining of tumor cells (A), and strong positive cytoplasmic immunostaining of myoepithelial cells in hyperplastic duct (B). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG V21-R Aff - Purified Hu C, P
0.5 ml / €400.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 17 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human squamous skin carcinoma (A, 4 μm), and human breast tissue (B, 4 μm), stained with anti-Cytokeratin 17 antibody (DB 101) shows strong positive cytoplasmic immunostaining of tumor cells (A), and strong positive cytoplasmic immunostaining of myoepithelial cells in hyperplastic duct (B). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG V21-R Aff - Purified Hu C, P
1 ml / €610.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 17 (C-term) antibody

Human prostate carcinoma stained with anti-keratin 17 antibody Rabbit IgG SP95 Purified Hu F, P, WB
0.5 ml / €510.00
  Acris Antibodies GmbH

Cytokeratin 17 (C-term) antibody

Human prostate carcinoma stained with anti-keratin 17 antibody Rabbit IgG SP95 Purified Hu F, P, WB
1 ml / €730.00
  Acris Antibodies GmbH

Cytokeratin 17 (C-term) antibody

Human prostate carcinoma stained with anti-keratin 17 antibody Rabbit IgG SP95 Purified Hu F, P, WB
0.1 ml / €290.00
  Acris Antibodies GmbH

Cytokeratin 17 antibody

Formalin-Paraffin skin stained with CK17 Antibody Cat.-No AM50131PU (Clone SPM560). Mouse IgG2b SPM560 Purified Bov, Gt, Hu, Por, Rt F, ICC/IF, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Cytokeratin 17 antibody

Formalin-Paraffin skin stained with CK17 Antibody Cat.-No AM50131PU (Clone SPM560). Mouse IgG2b SPM560 Purified Bov, Gt, Hu, Por, Rt F, ICC/IF, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cytokeratin 17 antibody

Formalin-Paraffin skin stained with CK17 Antibody Cat.-No AM50131PU (Clone SPM560). Mouse IgG2b SPM560 Purified Bov, Gt, Hu, Por, Rt F, ICC/IF, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Cytokeratin 17 (C-term) antibody

AP09591PU Cytokeratin-17 antibody staining of Human Lung Adenocarcinoma. Rabbit IgG Aff - Purified Hu P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

Cytokeratin 17 (C-term) antibody

AP09591PU Cytokeratin-17 antibody staining of Human Lung Adenocarcinoma. Rabbit IgG Aff - Purified Hu P, WB
1 ml / €520.00
  Acris Antibodies GmbH

Cytokeratin 17 (C-term) antibody

AP09591PU Cytokeratin-17 antibody staining of Human Lung Adenocarcinoma. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €190.00
  Acris Antibodies GmbH

Cytokeratin 17 antibody

Western blot analysis of extracts from HuvEc cells, using keratin 17 antibody (#TA314142).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cytokeratin 17 antibody

Predicted band size: 48kDa . Positive control: 231 and Hela cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1: 231 cell lysate Lane2: Hela cell lysate Lysates: 30 ug per lane Primary antibody: 1/200 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilution Exposure time: 1 second) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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