Cytokeratin 18 antibody

Principal name

Cytokeratin 18 antibody

Alternative names for Cytokeratin 18 antibody

Cytokeratin-18, CK18, Keratin-18, Keratin 18, KRT18, CYK18, K18, Cell proliferation-inducing gene 46 protein, Keratin type I cytoskeletal 18

SwissProt ID

A6H7D3 (Bovin), P05783 (Human), P05784 (Mouse), Q5BJY9 (Rat)

Gene ID

3875 (KRT18), 16668 (Krt18)

Available reactivities

Hu (Human), Mam (Mammalia), Can (Canine), Chk (Chicken), Hst (Hamster), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), Fe (Feline), Bov (Bovine), Sh (Sheep), Trout, African clawed frog, Av (Birds), Mky (Monkey), Fi (Fish)

Available hosts

Mouse, Guinea Pig, Rabbit, Sheep, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C), ELISA (detection) (E(detection))

Background of Cytokeratin 18 antibody

Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non keratinizing cells (ie. mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. At least 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18. This antibody reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid.

General readings

Lauerova L, Kovarik J, Bartek J, Rejthar A, Vojtesek B.: Novel monoclonal antibodies
defining epitope of human cytokeratin 18 molecule. Hybridoma. 1988 Oct;7(5):495-504.
Kovarik J, Rejthar A, Lauerova L, Vojtesek B, Bartkova J.: Monoclonal antibodies against
individual cytokeratins in the detection of metastatic spread. Int J Cancer Suppl. 1988;3:50-5.
Vojtesek B, Staskova Z, Nenutil R, Lauerova L, Kovarik J, Rejthar A, Bartkova J, Bartek J.: Monoclonal antibodies recognizing different epitopes of cytokeratin No.18. Folia Biol (Praha). 1989;35(6):373-82.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-KRT18 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500015) Mouse IgG1 OTI1E1 Purified Hu, Mky ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded carcinoma of human thyroid using anti-KRT18 mouse monoclonal antibody. (UM500045; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB50 Purified Hu, Mky P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded carcinoma of human thyroid using anti-KRT18 mouse monoclonal antibody. (UM500045; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB50 Purified Hu, Mky P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 18 antibody

Formalin-Fixed, Paraffin-Embedded Human skin sweat gland stained with CytoKeratin-18 Antibody Cat.-No AM33119PU (Clone DC10). Note cytoplasmic staining of tumor cells. Mouse IgG1 DC10 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Formalin-Fixed, Paraffin-Embedded Human skin sweat gland stained with CytoKeratin-18 Antibody Cat.-No AM33119PU (Clone DC10). Note cytoplasmic staining of tumor cells. Mouse IgG1 DC10 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Formalin-Fixed, Paraffin-Embedded Human skin sweat gland stained with CytoKeratin-18 Antibody Cat.-No AM33119PU (Clone DC10). Note cytoplasmic staining of tumor cells. Mouse IgG1 DC10 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

BM2275F KRT18 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Prostate followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 Ks18.04 FITC Bov, Can, Hst, Hu, Ms, Por, Rt, Sh, Trout C, F, ICC/IF, P
0.25 ml / €340.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Cytokeratin 18 Mouse IgG1 Ks18.04 Purified Bov, Can, Hst, Hu, Ms, Por, Rt, Sh, Trout, Ze C, P, WB
50 µg / €290.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Immunohistochemistry staining of human colon (paraffin sections) using anti-cytokeratin 18 (clone DC-10). Mouse IgG1 DC-10 FITC Hu F, ICC/IF, P
0.1 mg / €270.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Immunohistochemistry staining of human colon (paraffin sections) using Cytokeratin 18 Antibody (clone DC-10). Mouse IgG1 DC-10 Purified Hu E, ICC/IF, IP, P, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Immunohistochemistry staining of Human colon (Paraffin Sections) using anti-Cytokeratin 18 antibody (clone DA-7). Mouse IgG1 DA-7 Purified Hu E, ICC/IF, IP, P, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-KRT18 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500016) Mouse IgG2b OTI5E8 Purified Can, Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-KRT18 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500017) Mouse IgG2a OTI1H10 Purified Hu, Mky ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-KRT18 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA806998)(1:150) Mouse IgG1 OTI2H10 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-KRT18 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120 oC for 3 min, TA807190)(1:150) Mouse IgG1 OTI3D1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 18 (C-term) antibody

Human breast Adenocarcinoma stained with anti-Cytokeratin 18 Antibody Cat.-No AM09115PU (Clone SP69). Rabbit IgG SP69 Purified Hu F, P, WB
0.5 ml / €520.00
  Acris Antibodies GmbH

Cytokeratin 18 (C-term) antibody

Human breast Adenocarcinoma stained with anti-Cytokeratin 18 Antibody Cat.-No AM09115PU (Clone SP69). Rabbit IgG SP69 Purified Hu F, P, WB
1 ml / €750.00
  Acris Antibodies GmbH

Cytokeratin 18 (C-term) antibody

Human breast Adenocarcinoma stained with anti-Cytokeratin 18 Antibody Cat.-No AM09115PU (Clone SP69). Rabbit IgG SP69 Purified Hu F, P, WB
0.1 ml / €290.00
  Acris Antibodies GmbH

Cytokeratin 18 (79-430) antibody

Immunofluorescence of HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and monoclonal anti-human Cytokeratin-18 antibody (1:500) with Texas Red (Red). Mouse IgG2b AT2G3 Purified Hu E, F, ICC/IF, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Cytokeratin 18 (79-430) antibody

Immunofluorescence of HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and monoclonal anti-human Cytokeratin-18 antibody (1:500) with Texas Red (Red). Mouse IgG2b AT2G3 Purified Hu E, F, ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

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