Cytokeratin 18 antibody

Principal name

Cytokeratin 18 antibody

Alternative names for Cytokeratin 18 antibody

Cytokeratin-18, CK18, Keratin-18, Keratin 18, KRT18, CYK18, K18, Cell proliferation-inducing gene 46 protein, Keratin type I cytoskeletal 18

SwissProt ID

A6H7D3 (Bovin), P05783 (Human), P05784 (Mouse), Q5BJY9 (Rat)

Gene ID

3875 (KRT18), 16668 (Krt18), 294853

Available reactivities

Hu (Human), Mam (Mammalia), Can (Canine), Chk (Chicken), Hst (Hamster), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), Fe (Feline), Bov (Bovine), Sh (Sheep), Trout, African clawed frog, Av (Birds), Mky (Monkey), Fi (Fish)

Available hosts

Mouse, Guinea Pig, Rabbit, Sheep, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C), ELISA (detection) (E(detection))

Background of Cytokeratin 18 antibody

Keratin 18 (also know as cytokeratin 18) is a 48 kD member of the Type I intermediate filament family, that forms heterotetramers. Keratin 18 is widely expressed in normal single layer epithelial tissues (liver, pancreas) and is expressed at high levels in some tumor tissues. Keratin 18 and filament partner keratin 8 are the most common members of intermediate filament family. Mutations in keratin 18 have been linked to cryptogenic cirrhosis. This protein is induced by retinoic acid, estrogen (breast cancer cells), and the Ras-signaling pathway (Ha-Ras, activated Src, Lck, Raf). Keratin 18 can be modified by phosphorylation, glycosylation, and ubiquitination. The active heterotetramer consists of two type I and two type II keratins (type I is acidic 40-55 kD, type II is neutral to basic 56-70 kD). Keratin 18 has been shown to associate with keratin 8, Mrj (a DnaJ/HSP40 family protein), and Hsp70. The Poly6172 antibody recognizes human and mouse keratin 18 and is useful for Western blotting.

General readings

Lauerova L, Kovarik J, Bartek J, Rejthar A, Vojtesek B.: Novel monoclonal antibodies
defining epitope of human cytokeratin 18 molecule. Hybridoma. 1988 Oct;7(5):495-504.
Kovarik J, Rejthar A, Lauerova L, Vojtesek B, Bartkova J.: Monoclonal antibodies against
individual cytokeratins in the detection of metastatic spread. Int J Cancer Suppl. 1988;3:50-5.
Vojtesek B, Staskova Z, Nenutil R, Lauerova L, Kovarik J, Rejthar A, Bartkova J, Bartek J.: Monoclonal antibodies recognizing different epitopes of cytokeratin No.18. Folia Biol (Praha). 1989;35(6):373-82.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-KRT18 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500015) Mouse IgG1 OTI1E1 Purified Hu, Mky ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded carcinoma of human thyroid using anti-KRT18 mouse monoclonal antibody. (UM500045; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB50 Purified Hu, Mky P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded carcinoma of human thyroid using anti-KRT18 mouse monoclonal antibody. (UM500045; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB50 Purified Hu, Mky P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 18 antibody

Formalin-Fixed, Paraffin-Embedded Human skin sweat gland stained with CytoKeratin-18 Antibody Cat.-No AM33119PU (Clone DC10). Note cytoplasmic staining of tumor cells. Mouse IgG1 DC10 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Formalin-Fixed, Paraffin-Embedded Human skin sweat gland stained with CytoKeratin-18 Antibody Cat.-No AM33119PU (Clone DC10). Note cytoplasmic staining of tumor cells. Mouse IgG1 DC10 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Formalin-Fixed, Paraffin-Embedded Human skin sweat gland stained with CytoKeratin-18 Antibody Cat.-No AM33119PU (Clone DC10). Note cytoplasmic staining of tumor cells. Mouse IgG1 DC10 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

BM2275F KRT18 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Prostate followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 Ks18.04 FITC Bov, Can, Hst, Hu, Ms, Por, Rt, Sh, Trout C, F, ICC/IF, P
0.25 ml / €350.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Cytokeratin 18 Mouse IgG1 Ks18.04 Purified Bov, Can, Hst, Hu, Ms, Por, Rt, Sh, Trout, Ze C, P, WB
50 µg / €300.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Immunohistochemistry staining of human colon (paraffin sections) using anti-cytokeratin 18 (clone DC-10). Mouse IgG1 DC-10 FITC Hu F, ICC/IF, P
0.1 mg / €270.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Immunohistochemistry staining of human colon (paraffin sections) using Cytokeratin 18 Antibody (clone DC-10). Mouse IgG1 DC-10 Purified Hu E, ICC/IF, IP, P, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Immunohistochemistry staining of Human colon (Paraffin Sections) using anti-Cytokeratin 18 antibody (clone DA-7). Mouse IgG1 DA-7 Purified Hu E, ICC/IF, IP, P, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-KRT18 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500016) Mouse IgG2b OTI5E8 Purified Can, Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-KRT18 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500017) Mouse IgG2a OTI1H10 Purified Hu, Mky ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-KRT18 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA806998)(1:150) Mouse IgG1 OTI2H10 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 18 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-KRT18 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120 oC for 3 min, TA807190)(1:150) Mouse IgG1 OTI3D1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 18 (C-term) antibody

Human breast Adenocarcinoma stained with anti-Cytokeratin 18 Antibody Cat.-No AM09115PU (Clone SP69). Rabbit IgG SP69 Purified Hu F, P, WB
0.5 ml / €530.00
  Acris Antibodies GmbH

Cytokeratin 18 (C-term) antibody

Human breast Adenocarcinoma stained with anti-Cytokeratin 18 Antibody Cat.-No AM09115PU (Clone SP69). Rabbit IgG SP69 Purified Hu F, P, WB
1 ml / €760.00
  Acris Antibodies GmbH

Cytokeratin 18 (C-term) antibody

Human breast Adenocarcinoma stained with anti-Cytokeratin 18 Antibody Cat.-No AM09115PU (Clone SP69). Rabbit IgG SP69 Purified Hu F, P, WB
0.1 ml / €300.00
  Acris Antibodies GmbH

Cytokeratin 18 (79-430) antibody

Immunofluorescence of HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and monoclonal anti-human Cytokeratin-18 antibody (1:500) with Texas Red (Red). Mouse IgG2b AT2G3 Purified Hu E, F, ICC/IF, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Cytokeratin 18 (79-430) antibody

Immunofluorescence of HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and monoclonal anti-human Cytokeratin-18 antibody (1:500) with Texas Red (Red). Mouse IgG2b AT2G3 Purified Hu E, F, ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

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