Cytokeratin 19 antibody

Principal name

Cytokeratin 19 antibody

Alternative names for Cytokeratin 19 antibody

Cytokeratin-19, Keratin-19, KRT19, CK19, K19, Keratin type I cytoskeletal 19

SwissProt ID

O93256 (Chick), P08727 (Human), P08728 (Bovin), P19001 (Mouse), Q63279 (Rat)

Gene ID

3880 (KRT19), 16669 (Krt19)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Can (Canine), Chk (Chicken), African clawed frog, Mky (Monkey), Amph (Amphibian), Ze (Zebrafish), Fi (Fish), Rb (Rabbit), Xen (Xenopus), Por (Porcine)

Available hosts

Rabbit, Mouse, Guinea Pig, Goat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F), ELISA (detection) (E(detection)), Immunoelectron Microscopy (EM), Luminex (LMNX)

Background of Cytokeratin 19 antibody

Cytokeratin 19 (KRT19) is an intermediate filament (IF) protein that is part of the Keratin family of proteins. This protein is also known by the names of Keratin 19 or Keratin type I Cytoskeletal 19. The Keratin family consists of Keratin 1-20, which are divided into two subtypes: Type 1 contains the acidic Cytokeratin proteins consisting of Cytokeratins 9-20, including KRT19; Type 2 Keratins include the basic to neutral protein and contains Cytokeratin 1-8. Type 1 and Type 2 Keratins often form oligomers, interacting to create heterotypic chains. However, KRT19 is unique in that while being the smallest of the Type 1 Keratin proteins, it does not interact with any Type 2 Keratins. IF proteins such as KRT19 are integral for defining and maintaining cellular structure and morphology, and are important for cellular integrity by anchoring to membrane complexes via proteins such as Epiplakin, Trichoplein, Periplakin, Plakophilins, Plectin, BPAG1, Desmoplakin, and Envoplakin. KRT19 is also involved in the organization of the myofibers of striated muscle. KRT19 and other Cytokeratin proteins are mainly found in epithelial cells, with KRT19 being expressed exclusively in defined zones of basal keratinocytes. KRT19 is an important biomarker for breast cancer cells, tumor cells of the lymph nodes, peripheral blood, and bone marrow. Cytokeratin 19 can be expressed with KRT8 and KRT18 to differentiate cells of epithelial lines from hematopoietic tumor cells in the peripheral blood.

General readings

Bader, B.L. and Franke, W.W: Celltype-specific and efficient synthesis of human cytokeratin 19 in trangenic mice. D differentiation 45 109-118 (1990).
Bosch, F.X., Ouhayoun, J.-P., Bader, B.L., Collin, C., Grund, C., Lee, I. and Franke, W.W.: Extensive changes in cytokeratin expression patterns in pathologically affected human gingiva. Virchows Arch. B Cell Pathol. 58, 59-77 (1989).
Bosch, F.X., Leube, R.E., Achstatter, T., Moll, R. and Franke, W.W.: Expression of simple epithelial type of cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ. J. Cell Bio. 106, 1635-1648 (1988).
Dockhorn-Dworniczak, B., Franke, W.W., Schroder, S., Czernobilsky, B., Gould, V.E. and Bocker, W.: Patterns of expression of cytoskeletal proteins in human thyroid gland and thyroid carcinomas. Differentiation 35, 53-71 (1987).
Heid, H.W., Moll, I. and Franke, W.W.: Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles. Differentiation 37, 137-157 (1988).
Heid, H.W., Moll, I. and Franke, W.W.: Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. II. Concomittant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum). Differentiation 37, 215-230 (1988).
Moll, R., Franke, W.W., Schiller, D.L., Geiger, B. and Krepler, R.: The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells. Cell 31, 11-24 (1982).
Moll, I., Heid, H.W., and Moll, R.: Cytokeratin analysis of pilomatrixoma: Changes in cytokeratin-type expression during differentiation. J.Invest. Dermatol. 91, 251-257 (1988).
Moll.I and Moll R.: Comparative cytokeratin analysis of sweat gland ducts and eccrine poromas. Arch Dermatol Res. 283, 300-309 (1991).
Moll R., Schiller, D.L. and Franke, W.W.,: Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J. Cell Biol. 111, 567-580 (1990).
Hasholzer U, Schambeck C, Fabricius PG, Stieber P, Hofmann K, Jansen H-M, Schmeller N, Fateh-Moghadam A: Die klinische Relevanz des neuen Tumormarkers CYFRA 21-1 bei Blasenkarzinomen im Verghleich zu TPA und TPS. Lab Med 17, 324-327 (1993).
Stieber P, Hasholzner U, Bodenmueller H, Nagel D, Sunder-Plassmen L, Dienemann H, Meier W, Fateh-Moghadam A: CYFRA 21-1, a new marker in lung cancer. Cancer 72, 707-713 (1990).
Pujol JL, Grenier J, Daures JP, Daver A, Pujol H, Michel FB: Serum fragment of cytokeratin subunit 19 measured by CYFRA 21-1 immunoradiometric assay as a marker of lung cancer. Cancer Res. 53, 61-66 (1993).
Van der Gaast A, Schoenmakers CHH, Kok TC, Blijenberg BG, Cornillie F, Splinter TAW: Evaluation of a new tomor marker in patients with non-small cell lung cancer: CYFRA 21.1. Br. J Cancer 69, 525-528 (1994).
Sugama Y, Kitamura S, Kawai T, Ohkubo A, Hasegawa S, Kuriyama T, Kato H, Fukuoka M, Ohkawa J: Clinical usefulness of CYFRA assay in diagnosing lung cancer: Measurement of serum cytokeratinfragment. Jpn J Cancer Res 85, 1178-1184 (1994).
Petersen G, Song D, Huegle-Doerr B, Oldenbug I, Bautz EKF: Mappingof linear epitopes recognized by monoclonal antibodies with gene-fragment phage display libraies. Mol Gen Genet 249, 425-431.
Dittadi R, Barioli P, Gion M, Mione R, Barichello M, Capitanio G, Cocco G, Cazzolato G, De Biasi F, Praturlon S, Antinozzi R, Gianneo E: Standardization of assay for cytokeratin-related tumor marker CYFRA21.1 in urine samples. Clin Chemistry 42, 1634-1638 (1996).
Hoechtlen-Vollmar W, Gruber R, Bodenmueller H, Felber E, Lindemann F, Passlick, B, Schlimok G, Pantel K, Riethmueller G: Occult epithelial tumor cells detected in bone marrow by an enzyme immunoassay specific for cytokeratin 19. Int. J Cancer 70, 396-400 (1997).
Stigbrand T, Andres C, Bellanger L, Bishr Omary M, Bodenmueller H, Bonfer H, Brundell J, Einarsson R, Erlandsson A, Johansson A, Leca JF, Levi M, Meier T, Nap M, Nustad K, Seguin P, Sjoedin A, Sundstroem B, Van Dalen A, Wiebelhaus E, Wiklund B, Yrlestig L, Hilgers J: Epitope specificity of 30 monoclonal antibodies against cytokeratin antigens: The ISOBM TD5-1 Workshop. Tumor Biol 19, 132-152 (1998).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-KRT19 mouse monoclonal antibody (TA500212) at 1:150 dilution. Mouse IgG1 OTI3F8 Purified Can, Hu, Mky, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas tissue using anti-KRT19mouse monoclonal antibody. (Clone UMAB2, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB2 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of lung tissue using anti-KRT19mouse monoclonal antibody. (Clone UMAB3, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB3 Purified Can, Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas tissue using anti-KRT19mouse monoclonal antibody. (Clone UMAB2, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB2 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of lung tissue using anti-KRT19mouse monoclonal antibody. (Clone UMAB3, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB3 Purified Can, Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-KRT19 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH9.0) at 120C for 3 min, UM800078)(1:200) Mouse IgG1 UMAB186 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-KRT19 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800079)(1:400) Mouse IgG2a UMAB187 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-KRT19 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 110C for 10 min, UM800080)(1:200) Mouse IgG2a UMAB188 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-KRT19 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH9.0) at 120C for 3 min, UM800078)(1:200) Mouse IgG1 UMAB186 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-KRT19 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800079)(1:400) Mouse IgG2a UMAB187 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-KRT19 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 110C for 10 min, UM800080)(1:200) Mouse IgG2a UMAB188 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 19 antibody

Western Blot: Cytokeratin 19 Antibody [TA336845] - Analysis of Cytokeratin 19 in MCF7 lysate. Rabbit Purified Hu C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cytokeratin 19 antibody

Western Blot: Cytokeratin 19 Antibody (4E8) [TA336915] - Western blot analysis using Cytokeratin 19 mAb against human Cytokeratin 19 (AA: 115-269) recombinant protein. (Expected MW is 43.1 kDa) Mouse IgG1 4E8 Purified Hu E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-KRT19 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500018) Mouse IgG1 OTI5D1 Purified Can, Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Human bladder tissue within the normal limits using anti-KRT19 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500019) Mouse IgG1 OTI2F8 Purified Can, Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-KRT19mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500213, Dilution 1:50) Mouse IgG1 OTI4E12 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-KRT19 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803602) Mouse IgG1 OTI1F5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Human lung tissue within the normal limits using anti-KRT19 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803859) Mouse IgG1 OTI1E7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-KRT19 mouse monoclonal antibody. (TA803860; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG2a OTI5B11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 19 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-KRT19 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803863) Mouse IgG2a OTI6A8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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