Cytokeratin 5 antibody

Principal name

Cytokeratin 5 antibody

Alternative names for Cytokeratin 5 antibody

KRT5, Cytokeratin-5, Keratin-5, Keratin 5, CK5, K5, Keratin type II cytoskeletal 5, 58 kDa Cytokeratin

SwissProt ID

P13647 (Human), Q5XQN5 (Bovin), Q6P6Q2 (Rat), Q922U2 (Mouse)

Gene ID

54474 (KRT20), 3852 (KRT5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Hst (Hamster), Por (Porcine), Sh (Sheep), Mky (Monkey), Amph (Amphibian), Hydra, Rb (Rabbit), Fe (Feline), Mam (Mammalia)

Available hosts

Mouse, Rabbit, Guinea Pig

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C), ELISA (detection) (E(detection))

Background of Cytokeratin 5 antibody

Cytokeratin 5 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.

General readings

1. Shum WW  et al. Epithelial basal cells are distinct from dendritic cells and macrophages in the mouse epididymis. Biol Reprod 90:90 (2014). Flow Cyt, ICC/IF ; Mouse .PubMed: 24648397
2. Menzl I  et al. Loss of primary cilia occurs early in breast cancer development. Cilia 3:7 (2014). ICC/IF ; Human .PubMed: 24987519
3. Rodriguez M  et al. PSGR promotes prostatic intraepithelial neoplasia and prostate cancer xenograft growth through NF-?B. Oncogenesis 3:e114 (2014).PubMed: 25111863
4. Wang C  et al. Estrogenic modulation of uropathogenic Escherichia coli infection pathogenesis in a murine menopause model. Infect Immun 81:733-9 (2013). IHC-P ; Mouse .PubMed: 23264047
5. Olsen JR  et al. p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One 8:e62547 (2013).PubMed: 23658742
6. Yang Z  et al. Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a ß-catenin-dependent manner. Mol Cell Biol 33:4732-44 (2013).PubMed: 24081330
7. Volkmer JP  et al. Three differentiation states risk-stratify bladder cancer into distinct subtypes. Proc Natl Acad Sci U S A 109:2078-83 (2012). IHC-Fr ; Human .PubMed: 22308455
8. Yuan W  et al. Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations. Oncogene : (2012). ICC/IF ; Mouse .PubMed: 22370636
9. Malkoski SP  et al. Loss of transforming growth factor beta type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma. Clin Cancer Res 18:2173-83 (2012). IHC-P ; Mouse .PubMed: 22399565
10. Johnen N  et al. Evidence for a partial epithelial-mesenchymal transition in postnatal stages of rat auditory organ morphogenesis. Histochem Cell Biol : (2012). IHC-Fr ; Rat .PubMed: 22610129
11. Sanos SL  et al. Stromal cell networks regulate thymocyte migration and dendritic cell behavior in the thymus. J Immunol 186:2835-41 (2011). IHC-FoFr ; Mouse .PubMed: 21278345

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cytokeratin 5+6 antibody

Formalin-Fixed, Paraffin-Embedded Human prostate carcinoma stained with Cytokeratin-5/6 antibody Cat.-No. AM10102SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of basal cells of benign but not tumor glands. Mouse IgG1 D5/16 B4 Supernatant Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Cytokeratin 5 antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-KRT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800714) Mouse IgG1 OTI1F8 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 5 antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-KRT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800727) Mouse IgG1 OTI6F8 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 5 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-KRT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800728) Mouse IgG1 OTI1C7 Purified Hu, Rt P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 5 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-KRT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801063) Mouse IgG2a OTI1E7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 5 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-KRT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801092) Mouse IgG1 OTI4A7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 5 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-KRT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801104) Mouse IgG2b OTI4H8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 5 antibody

Immunohistochemical analysis of paraffin-embedded breast cancer (left) and  stomach (right) tissues using Cytokeratin 5 antibody Cat.-No AM06747PU-N  with DAB staining. Mouse IgG1 2C2 Purified Hu, Mky, Ms E, F, ICC/IF, P, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Cytokeratin 5 (C-term) antibody

Human Thymus stained with Cytokeratin 5 antibody Cat.-No AM11167PU (Clone SP27). Rabbit SP27 Supernatant Hu F, P, WB
0.5 ml / €490.00
  Acris Antibodies GmbH

Cytokeratin 5 (C-term) antibody

Human Thymus stained with Cytokeratin 5 antibody Cat.-No AM11167PU (Clone SP27). Rabbit SP27 Supernatant Hu F, P, WB
1 ml / €700.00
  Acris Antibodies GmbH

Cytokeratin 5 (C-term) antibody

Human Thymus stained with Cytokeratin 5 antibody Cat.-No AM11167PU (Clone SP27). Rabbit SP27 Supernatant Hu F, P, WB
0.1 ml / €290.00
  Acris Antibodies GmbH

Cytokeratin 5 antibody

Tonsil, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 1E1 Ascites Hu E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Cytokeratin 5 (+ KRT8) antibody

RCK102 Cytokeratin staining of a human squamous cell carcinoma of the lung. Mouse IgG1 RCK102 Purified Can, Fe, Hst, Hu, Ms, Por, Rb, Rt C, F, ICC/IF, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cytokeratin 5 (C-term) antibody

Human skin stained with anti-keratin 5 antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Cytokeratin 5 (C-term) antibody

Human skin stained with anti-keratin 5 antibody Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Cytokeratin 5 (C-term) antibody

Human skin stained with anti-keratin 5 antibody Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Cytokeratin 5 antibody

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using KRT5 Antibody at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cytokeratin 5 antibody

Predicted cell location: Cytoplasm, Cell membrane . Positive control: Human cervical cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using KRT5 antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cytokeratin 5 antibody

Western blot analysis of extracts of various cell lines, using KRT5 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cytokeratin 5 antibody

Immunohistochemistry staining of Paraffin Mesothelioma, prostate tissue by Cytokeratin 5 antibody (dilution: 1:50 - 1:200; visualization of staining: Cytoplasmic) Rabbit IgG EP1601Y Purified Hu P
1 ml / €490.00
  OriGene Technologies, Inc.

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