Cytokeratin 7 antibody

Principal name

Cytokeratin 7 antibody

Alternative names for Cytokeratin 7 antibody

KRT7, KRT-7, SCL, CK-7, CK7, Keratin-7, K7, K-7, Sarcolectin, Keratin type II cytoskeletal 7

SwissProt ID

P08729 (Human), Q29S21 (Bovin), Q6IG12 (Rat), Q9DCV7 (Mouse)

Gene ID

3855 (KRT7), 110310 (Krt7)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Por (Porcine), Sh (Sheep), Ms (Mouse), Rt (Rat), Fe (Feline), Gt (Goat), Hst (Hamster), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Guinea Pig

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of Cytokeratin 7 antibody

The cytokeratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. Keratin proteins belong to 2 families: acidic (or type I) and basic (or type II). The acidic keratins are coded by genes KRT9 to 19, the basic keratins by genes KRT1 to 8. Cytokeratins 7, 17 and 19 are encoded by the genes KRT7, 17 and 19 respectively. Type I and II keratins are usually coordinately synthesized in preferential pairs so that at least 1 member of each family is expressed in each epithelial cell, in equal proportions. Cytokeratin 7 is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. Cytokeratin 17 is normally expressed in the basal cells of complex epithelia (e.g. nail bed, hair follicle, sebaceous glands) but not in stratified or simple epithelia. Synthesis of cytokeratin 17 seems to be a marker of basal cell differentiation in complex epithelia. Mutations in the gene KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. Unlike its related family members, cytokeratin 19 (the smallest known acidic cytokeratin at 40kDa) is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. It is often expressed in cultured epithelial cells and in some carcinomas.

General readings

1. Ramaekers, F., van Niekerk, C., Poels, L., Schaafsma, E., Huijsmans, A., Robben, H., Schaart, G., and Vooijs, P. (1990). Use of monoclonal antibodies to keratin 7 in the
differential diagnosis of adenocarcinomas, Am J Pathol 136, 641-55.
2. van Niekerk, C. C., Jap, P. H., Ramaekers, F. C., van de Molengraft, F., and Poels, L. G. (1991). Immunohistochemical demonstration of keratin 7 in routinely fixed paraffin-embedded human tissues, J Pathol 165, 145-52.
3. van Niekerk, C. C., Boerman, O. C.,Ramaekers, F. C., and Poels, L. G. (1991). Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas, Am J Pathol 138, 455-63.
4. van de Molengraft, F. J., van Niekerk, C. C., Jap, P. H., and Poels, L. G. (1993). OV-TL 12/30 (keratin 7 antibody) is a marker of glandular differentiation in lung cancer,
Histopathology 22, 35-8.
5. van Niekerk, C. C., Vooijs, P., Casparie-van Velsen, I. J., and Poels, L. G. (1997). Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies, Cancer Detect Prev 21, 247-57.
6. Torenbeek, R., Lagendijk, J. H., Van Diest, P. J., Bril, H., van de Molengraft, F. J., and Meijer, C. J. (1998). Value of a panel of antibodies to identify the primary origin of adenocarcinomas presenting as bladder carcinoma, Histopathology 32, 20-7.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cytokeratin 7 antibody

Immunohistochemistry analysis of Cytokeratin 7 antibody (Cat.-No AP06204PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cytokeratin 7 (+ KRT17) antibody

Immunohistochemistry staining of pancreas (paraffin-embedded sections) with anti-Cytokeratin 7+17  Antibody Cat.-No SM3046P (Clone C-46). Mouse IgG1 C-46 Purified Bov, Hu C, ICC/IF, IP, P, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

Cytokeratin 7 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-KRT7 mouse monoclonal antibody. (UM800056, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB161 Purified Hu P
0.1 ml / €379.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 7 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-KRT7 mouse monoclonal antibody. (UM800056, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB161 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 7 antibody

Western blot analysis of extracts from HepG2 cells, using Keratin 7 antibody (#TA312235).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cytokeratin 7 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-KRT7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802932) Mouse IgG1 OTI1C5 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 7 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-KRT7 mouse monoclonal antibody. (TA802933) Dilution: 1:150 Mouse IgG1 OTI1G6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 7 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-KRT7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA803026) Mouse IgG1 OTI1B3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 7 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-KRT7 mouse monoclonal antibody. (TA803027) Dilution: 1:150 Mouse IgG1 OTI1B6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 7 antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-KRT7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA803065) Mouse IgG1 OTI3B7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 7 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-KRT7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803077) Mouse IgG1 OTI2A2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 7 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-KRT7 mouse monoclonal antibody. (TA803188) Dilution: 1:150 Mouse IgG1 OTI2E11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 7 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-KRT7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min, TA803333) Mouse IgG1 OTI3E5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 7 antibody

Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 5D12 Ascites Hu E, F, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Cytokeratin 7 antibody

Immunohistochemistry on Paraffin Sections of Human pancreas: epithelia strongly positive. Mouse IgG1 OVTL-12/30 Purified Hu C, F, ICC/IF, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Cytokeratin 7 antibody

Immunohistochemistry-Paraffin: pan Cytokeratin  Antibody (7H8C4) [NBP1-51537] - Human lung squamous cell carcinoma (A),normal hepatocyte (B), colon adenocacinoma?, normal stomach tissue (D), showing cytoplasmic and membrane localization using CK mouse mAb with DAB staining. Mouse IgG1 7H8C4 Purified Hu E, ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Cytokeratin 7 (N-term) antibody

Formalin-Fixed, Paraffin-Embedded Human pancreatic tissue (4 µm) stained with anti-Cytokeratin 7 antibody (DB 051) shows positive immunostaining of pancreatic adenocarcinoma. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R17-S Aff - Purified Hu P
0.1 ml / €250.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 7 (N-term) antibody

Formalin-Fixed, Paraffin-Embedded Human pancreatic tissue (4 µm) stained with anti-Cytokeratin 7 antibody (DB 051) shows positive immunostaining of pancreatic adenocarcinoma. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R17-S Aff - Purified Hu P
0.2 ml / €330.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 7 (N-term) antibody

Formalin-Fixed, Paraffin-Embedded Human pancreatic tissue (4 µm) stained with anti-Cytokeratin 7 antibody (DB 051) shows positive immunostaining of pancreatic adenocarcinoma. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R17-S Aff - Purified Hu P
0.5 ml / €410.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 7 (N-term) antibody

Formalin-Fixed, Paraffin-Embedded Human pancreatic tissue (4 µm) stained with anti-Cytokeratin 7 antibody (DB 051) shows positive immunostaining of pancreatic adenocarcinoma. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R17-S Aff - Purified Hu P
1 ml / €630.00
  DB Biotech, spol. s r.o.

Sample sizes available

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