Cytokeratin 8 antibody

Principal name

Cytokeratin 8 antibody

Alternative names for Cytokeratin 8 antibody

KRT8, CYK8, Cytokeratin-8, CK8, Keratin-8, K8, Cytokeratin endo A, Keratin, type II cytoskeletal 8

SwissProt ID

P05786 (Bovin), P05787 (Human), P11679 (Mouse), Q10758 (Rat)

Gene ID

3856 (KRT8), 281269

Available reactivities

Bov (Bovine), Hu (Human), Por (Porcine), Sh (Sheep), Rb (Rabbit), Mam (Mammalia), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Hst (Hamster), Chk (Chicken), Xen (Xenopus), African clawed frog, Can (Canine), Mky (Monkey)

Available hosts

Mouse, Guinea Pig, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of Cytokeratin 8 antibody

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 – 7.8. The individual cytokeratin polypeptides are numbered 1 to 20. 
The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. 
Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Cytokeratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with cytokeratin 18. Cytokeratin 8 is primarily found in the non squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18.

General readings

General / background references:Angus B et al. Cytokeratins in cervical dysplasia and neoplasia: a comparative study of immunohistochemical staining using monoclonal antibodies NCL-5D3, CAM 5.2, and PKK1. J Pathol 155:71-5 (1988). PubMed PMID: 2454306
Angus B et al. NCL-5D3: a new monoclonal antibody recognizing low molecular weight cytokeratins effective for immunohistochemistry using fixed paraffin-embedded tissue. J Pathol 153:377-84 (1987). PubMed PMID: 2448441

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cytokeratin 8 (+ KRT18) antibody

Cytokeratin 8 Mouse IgG2a 5D3 Ascites Hu C, P, WB
1 ml / €350.00
  Acris Antibodies GmbH

Cytokeratin 8 antibody

Formalin-Fixed, Paraffin-Embedded Human prostate stained with Cytokeratin 8 antibody Cat.-No SM3079P at 20 µg/ml after heat-induced antigen retrieval. Mouse IgG1 C-43 Aff - Purified Bov, Hu, Por, Rb, Sh ICC/IF, IP, P, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

Cytokeratin 8 antibody

Immunohistochemical staining of paraffin-embedded pancreas tissue using anti-KRT8mouse monoclonal antibody. (Clone UMAB1, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB1 Purified Hu, Mky ICC/IF, P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 8 antibody

Immunohistochemical staining of paraffin-embedded pancreas tissue using anti-KRT8mouse monoclonal antibody. (Clone UMAB1, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB1 Purified Hu, Mky ICC/IF, P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Cytokeratin 8 antibody

Western blot analysis of extracts of various cell lines, using KRT8 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cytokeratin 8 antibody

Anti-KRT8 mouse monoclonal antibody (TA500020) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY KRT8(RC209570). Mouse IgG2a OTI1B9 Purified Can, Hu, Mky ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 8 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-KRT8 mouse monoclonal antibody (TA500021) at 1:150 dilution. Mouse IgG2b OTI1B12 Purified Can, Hu, Mky, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 8 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-KRT8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500022) Mouse IgG1 OTI2E4 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 8 antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-KRT8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500216) Mouse IgG2a OTI4D12 Purified Can, Hu, Mky ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Cytokeratin 8 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma (A), lung cancer (B) and ovarian cancer tissue (C), showing membrane and cytoplasmic localization with DAB staining using Cytokeratin 8 antibody Cat.-No AM06284SU-N Mouse IgG1 8A5D12 Ascites Hu E, ICC/IF, P, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

Cytokeratin 8 antibody

Human Kidney; Rabbit Anti-KRT8 Antibody. Catalog Number: ARP42028. Paraffin Embedded Tissue: Human Kidney. Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; KRT8 Antibody (ARP42028_P050) in Human Kidney cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Hu, Ms, Por, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

Cytokeratin 8 antibody

Human Small intestine; Immunohistochemistry with Small intestine tissue at an antibody concentration of 5ug/ml using anti-KRT8 antibody (ARP42029_P050); KRT8 antibody - middle region (ARP42029_P050) in Human Small intestine cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Cytokeratin 8 antibody

Immunohistochemistry-Paraffin: Cytokeratin 8 Antibody (8A5D12) [NBP1-47533] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma(A), lung cancer(B) and ovarian cancer tissue(C), showing membrane and cytoplasmic localization with DAB staining using anti-CK8 antibody. Mouse IgG1 8A5D12 Purified Hu C, E, ICC/IF, P, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Cytokeratin 8 antibody

Immunofluorescence: Cytokeratin 8 Antibody (1B12) [NBP1-48281] - Immunofluorescent staining of HeLa cells using anti-KRT8 mouse monoclonal antibody. Mouse 1B12 Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €530.00
  Novus Biologicals Inc.

Cytokeratin 8 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast cancer tissue (A, 4 μm), Human stomach adenocarcinoma (B, 4 μm) and Human colon adenocarcinoma (C, 4 μm), stained with anti-Cytokeratin 8 antibody (DB 098) shows strong positive cytoplasmic immunostaining of neoplastic cells (A), strong positive cytoplasmic immunostaining of tumor cells (B, C). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R15-K Aff - Purified Hu C, P
0.1 ml / €250.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 8 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast cancer tissue (A, 4 μm), Human stomach adenocarcinoma (B, 4 μm) and Human colon adenocarcinoma (C, 4 μm), stained with anti-Cytokeratin 8 antibody (DB 098) shows strong positive cytoplasmic immunostaining of neoplastic cells (A), strong positive cytoplasmic immunostaining of tumor cells (B, C). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R15-K Aff - Purified Hu C, P
0.2 ml / €330.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 8 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast cancer tissue (A, 4 μm), Human stomach adenocarcinoma (B, 4 μm) and Human colon adenocarcinoma (C, 4 μm), stained with anti-Cytokeratin 8 antibody (DB 098) shows strong positive cytoplasmic immunostaining of neoplastic cells (A), strong positive cytoplasmic immunostaining of tumor cells (B, C). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R15-K Aff - Purified Hu C, P
0.5 ml / €410.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 8 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast cancer tissue (A, 4 μm), Human stomach adenocarcinoma (B, 4 μm) and Human colon adenocarcinoma (C, 4 μm), stained with anti-Cytokeratin 8 antibody (DB 098) shows strong positive cytoplasmic immunostaining of neoplastic cells (A), strong positive cytoplasmic immunostaining of tumor cells (B, C). Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R15-K Aff - Purified Hu C, P
1 ml / €630.00
  DB Biotech, spol. s r.o.

Sample sizes available

Cytokeratin 8 (C-term) antibody

Human breast ductal carcinoma stained with anti-Cytokeratin 8 antibody AM20269PU Rabbit IgG SP102 Purified Hu P
0.5 ml / €510.00
  Acris Antibodies GmbH

Cytokeratin 8 (C-term) antibody

Human breast ductal carcinoma stained with anti-Cytokeratin 8 antibody AM20269PU Rabbit IgG SP102 Purified Hu P
1 ml / €730.00
  Acris Antibodies GmbH

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