DAB1 antibody

Principal name

DAB1 antibody

Alternative names for DAB1 antibody

Disabled homolog 1

SwissProt ID

O75553 (Human), P97318 (Mouse), Q8CJH2 (Rat)

Gene ID

13131 (Dab1), 1600 (DAB1)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Chk (Chicken), Mky (Monkey), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Goat, Rabbit, Mouse, Sheep

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E)

Background of DAB1 antibody

Disabled 1 (Dab1) is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler and yotari mutant mice. Phenotypically, the mutation of this gene produces motor defects and ataxia, disruption of neuronal migration, and severe cerebellar hypoplasia. Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin. Dab1 contains a phosphotyrosine binding (PTB) domain in the amino terminus. Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) through stimulation of Src family kinases. Src family kinase and c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1. Dab1 also mediates activation of Akt (PKB) by reelin resulting in inhibition of glycogen synthase kinase 3 beta (GSK-3 beta) and decreased phosphorylation of the microtubule-associated protein, Tau. Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner and regulates, likely indirectly, Reelin-induced signaling during neural cortex development.

General readings

Arnaud L et al. Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol 13:9-17 (2003). PubMed PMID: 12526739
Beffert U et al. Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J Biol Chem 277:49958-64 (2002). PubMed PMID: 12376533
Keshvara L et al. Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1. J Biol Chem 276:16008-14 (2001). PubMed PMID: 11279201
Howell BW et al. Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development. Curr Biol 10:877-85 (2000). PubMed PMID: 10959835
5. Hiesberger, T., et al. Direct binding of reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phophorylation od disabled-1 and modulates tau phosphorylation. Nueron. 24(2): 481-489, 1999.
6. Homayouni, R., et al. Disabled-1 binds to the cytoplasmic domain of amylodi precursor-like protein 1. J. Neurosci. 19(17): 7507-7515, 1999.
7. Howell, B.W., et al. Reelin-induced tyrosine phosphorylation of disabled 1 during neuronal positioning. Genes Dev. 13(6): 643-648, 1999.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DAB1 (N-term) antibody

Western blot analysis using
Disabled-1 (NT) (1) and (CT) (2) on mouse brain extracts. Sheep IgG Purified Ms WB
0.25 mg / €360.00
  Acris Antibodies GmbH

DAB1 antibody

Western blot analysis of Dab1 expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DAB1 antibody

WB Suggested Anti-DAB1 Antibody Titration: 0.2-1 ug/ml; Positive Control: THP-1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

DAB1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using Dab1 antibody. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 ml / €270.00
  Acris Antibodies GmbH

DAB1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using Dab1 antibody. Rabbit Aff - Purified Hu, Ms, Rt P
50 µl / €230.00
  Acris Antibodies GmbH

DAB1 (C-term) antibody

Western blot analysis using Disabled-1 (NT) (1) and (CT) (2) on mouse brain extracts. Sheep IgG Purified Ms IP, WB
0.25 mg / €360.00
  Acris Antibodies GmbH

DAB1 antibody

Western blot (WB) analyzes of Dab1 antibody (Cat.-No.: AP20741PU-N) in extracts from HeLa cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

DAB1 antibody

Western blot (WB) analyzes of Dab1 antibody (Cat.-No.: AP20742PU-N) in extracts from HepG2 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

DAB1 antibody

Immunohistochemical staining of Formalin-fixed, Paraffin-embedded human intestine using anti-Dab1 antibody cat. no. AP39027PU-N Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

DAB1 antibody

Western Blot analysis of DAB1 expression in transfected 293T cell line (H00001600-T01) by DAB1 MaxPab polyclonal antibody.

Lane 1: DAB1 transfected lysate(60.83 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

DAB1 antibody

Western Blot analysis of DAB1 expression in transfected 293T cell line (H00001600-T01) by DAB1 MaxPab polyclonal antibody.

Lane 1: DAB1 transfected lysate(60.83 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

DAB1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using DAB1 polyclonal antibody ( Cat # PAB5309 ) . Rabbit Hu, Ms, Rt P
0.1 mg / €390.00
  Abnova Taiwan Corp.

DAB1 antibody

Western blot analysis using Dab1 polyclonal antibody mouse brain extracts. Sheep Purified Ms IP, WB
0.25 mg / €400.00
  Abnova Taiwan Corp.

DAB1 antibody

Western blot analysis using Dab1 polyclonal antibody mouse brain extracts. Sheep Purified Ms IP, WB
0.25 mg / €400.00
  Abnova Taiwan Corp.

DAB1 pTyr232 antibody

Western blot analysis of extracts from LOVO cells, using Dab1 (Phospho-Tyr232) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

DAB1 pTyr232 antibody

Western blot analysis of extracts from LOVO cells, using Dab1 (Phospho-Tyr232) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

DAB1 antibody

Immunofluorescence analysis of HepG2 cells, using Dab1 (Ab-220) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

DAB1 antibody

Immunofluorescence analysis of HepG2 cells, using Dab1 (Ab-220) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

DAB1 antibody

Immunofluorescence analysis of MCF7 cells, using Dab1 (Ab-232) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

DAB1 antibody

Immunofluorescence analysis of MCF7 cells, using Dab1 (Ab-232) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

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