DACT3 antibody

Principal name

DACT3 antibody

Alternative names for DACT3 antibody

dapper homolog 3, DAPPER3, RRR1, antagonist of beta-catenin dapper homolog 3, arginine-rich region 1 protein

SwissProt ID

Q0PHV7 (Mouse), Q96B18 (Human)

Gene ID

147906 (DACT3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), Bov (Bovine), Can (Canine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of DACT3 antibody

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/beta-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.

General readings

Jiang X, et al., (2008) Cancer Cell. 13(6):529–41.
Fisher DA, et al., (2006) Dev Dyn. 235(9):2620–30.

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  2. Highly Validated (2)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DACT3 antibody

Paraffin embedded sections of human gastric cancer tissue were incubated with anti-human DACT3 (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB) Mouse IgG1 2A5 Purified Hu, Ms E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

DACT3 antibody

Paraffin embedded sections of human gastric cancer tissue were incubated with anti-human DACT3 (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB) Mouse IgG1 2A5 Purified Hu, Ms E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

DACT3 antibody

Western blot analysis of Dact3 in rat brain tissue lysate with Dact3 antibody at 1 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DACT3 antibody

WB Suggested Anti-DACT3 Antibody; Titration: 1.0 ug/ml; Positive Control: MCF7 Whole Cell Rabbit IgG Purified Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

DACT3 antibody

WB Suggested Anti-DACT3 Antibody; Titration: 1.0 ug/ml; Positive Control: MCF7 Whole Cell Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

DACT3 Control Peptide

DACT3
50 µg / €160.00
  Acris Antibodies GmbH

DACT3 antibody

Paraffin embedded sections of human gastric cancer tissue were incubated with DACT3 monoclonal antibody, clone 2A5 ( Cat # MAB2064 ; 1 : 50 ) for 2 hours at room temperature. Antigen retrieval was performed in 100 mM sodium citrate buffer and detected using Diaminobenzidine ( DAB ). Mouse IgG1 2A5 Hu, Ms E, P, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

DACT3 antibody

DACT3 Mouse IgG1 2A5 Purified Hu E, P, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

DACT3 antibody

Western Blot: Dact3 Antibody [NBP1-76340] - Analysis of Dact3 in rat brain tissue lysate with Dact3 antibody at 1 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

DACT3 antibody

Immunohistochemistry-Paraffin: Dact3 Antibody [NBP1-81196] Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

DACT3 overexpression lysate

DACT3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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