DDIT4 antibody

Principal name

DDIT4 antibody

Alternative names for DDIT4 antibody

DNA-damage-inducible transcript 4, DDIT-4, REDD1, REDD-1, RTP801, HIF-1 responsive protein, Dig2, Protein regulated in development and DNA damage response 1

SwissProt ID

Q08E62 (Bovin), Q8VHZ9 (Rat), Q9D3F7 (Mouse), Q9NX09 (Human)

Gene ID

54541 (DDIT4), 74747 (Ddit4), 140942

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of DDIT4 antibody

REDD1 is a novel transcriptional target of p53 induced following DNA damage. During embryogenesis, REDD1 expression mirrors the tissue-specific pattern of the p53 family member p63, and TP63 null embryos show virtually no expression of REDD1, which is restored in mouse embryo fibroblasts following p63 expression. In differentiating primary keratinocytes, TP63 and REDD1 expression are coordinately downregulated, and ectopic expression of either gene inhibits in vitro differentiation. REDD1 appears to function in the regulation of reactive oxygen species (ROS); TP63 null fibroblasts have decreased ROS levels and reduced sensitivity to oxidative stress, which are both increased following ectopic expression of either TP63 or REDD1. Thus, REDD1 encodes a shared transcriptional target that implicates ROS in the p53-dependent DNA damage response and in p63-mediated regulation of epithelial differentiation.

General readings

Yoshida T., et al. (2010) Nat Med. 16(7):767-73.
Regazzetti C., et al. (2010) J Biol Chem. 285(8):5157-64.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DDIT4 (Center) antibody

  Rabbit Polyclonal RTP801 Antibody  
Western blot analysis of RTP801 in human kidney tissue lysate with RTP801 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DDIT4 (N-term) antibody

  Rabbit Polyclonal RTP801 Antibody  
Western blot analysis of RTP801 in 293 cell lysate with RTP801 antibody at (A) 2 and (B) 4 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DDIT4 antibody

  Rabbit Polyclonal Anti-DDIT4 Antibody - N-terminal region  
Host: Rabbit; Target Name: Ddit4; Sample Tissue: Rat Thymus lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

DDIT4 antibody

  Rabbit Polyclonal Anti-DDIT4 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (DDIT4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

DDIT4 (N-term) antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with DDIT4 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

DDIT4 - human gene knockout kit via CRISPR

DDIT4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DDIT4 - human gene knockout kit via CRISPR

DDIT4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DDIT4 - human gene knockout kit via CRISPR

DDIT4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DDIT4 - human gene knockout kit via CRISPR

DDIT4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ddit4 - mouse gene knockout kit via CRISPR

Ddit4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ddit4 - mouse gene knockout kit via CRISPR

Ddit4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ddit4 - mouse gene knockout kit via CRISPR

Ddit4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DDIT4

  Recombinant protein of human DNA-damage-inducible transcript 4 (DDIT4)  
DDIT4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

DDIT4 (1-232, His-tag)

DDIT4 Human Purified > 90 % E. coli
0.25 mg / €1,000.00
  Acris Antibodies GmbH

DDIT4 (1-232, His-tag)

DDIT4 Human Purified > 90 % E. coli
50 µg / €370.00
  Acris Antibodies GmbH

Lysates (Knockout)

Catalog No.    

DDIT4-knockout Cell lysate

DDIT4-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DDIT4 (mGFP-tagged) - Human DNA-damage-inducible transcript 4 (DDIT4), 200 uL, >10^7 TU/mL

Lenti ORF particles, DDIT4 (mGFP-tagged) - Human DNA-damage-inducible transcript 4 (DDIT4), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, DDIT4 (Myc-DDK tagged) - Human DNA-damage-inducible transcript 4 (DDIT4) , 200 uL, >10^7 TU/mL

Lenti ORF particles, DDIT4 (Myc-DDK tagged) - Human DNA-damage-inducible transcript 4 (DDIT4) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ddit4 (GFP-tagged) - Mouse DNA-damage-inducible transcript 4 (Ddit4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ddit4 (GFP-tagged) - Mouse DNA-damage-inducible transcript 4 (Ddit4), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ddit4 (Myc-DDK-tagged) - Mouse DNA-damage-inducible transcript 4 (Ddit4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ddit4 (Myc-DDK-tagged) - Mouse DNA-damage-inducible transcript 4 (Ddit4), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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