DEAF1 antibody

Principal name

DEAF1 antibody

Alternative names for DEAF1 antibody

SPN, ZMYND5, Suppressin, SPN, NUDR, Deformed epidermal autoregulatory factor 1 homolog, Nuclear DEAF-1-related transcriptional regulator, Zinc finger MYND domain-containing protein 5

SwissProt ID

O75398 (Human), O75512 (Human), O88450 (Rat), Q9Z1T5 (Mouse)

Gene ID

10522 (DEAF1), 54006 (Deaf1), 83632

Available reactivities

Hu (Human), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Dros (Drosophila), Bov (Bovine), GP (Guinea Pig), Ye (Yeast), Eq (Equine), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of DEAF1 antibody

Suppressin, also known as DEAF1 (deformed epidermal autoregulatory factor 1), SPN, NUDR (nuclear DEAF-1-related transcriptional regulator), or ZMYND5 (zinc finger MYND domain-containing protein 5), is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.

General readings

Pilot-Storck, F., et al. Mol. Cell Proteomics 9(7):1578-1593 (2010).
Gu, B., et al. Biochem. Biophys. Res. Commun. 394(2):418-423 (2010).
Yip, L., et al. Nat. Immunol. 10(9):1026-1033 (2009).
Egli, R.J., et al. Arthritis Rheum. 60(7):2055-2064 (2009).
Barker, H.E., et al. BMC Dev. Biol. 8, 94 (2008).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DEAF1 (C-term) antibody

Western blot analysis of Deaf1(arrow) using rabbit polyclonal Deaf1 Antibody (Human C-term) (Cat.#AP12323PU-N). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Deaf1 gene (Lane 2) (Origene Technologies). Rabbit Ig Aff - Purified Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DEAF1 (C-term) antibody

Western blot analysis of DEAF1 Antibody (C-term) Cat.-No AP51228PU-N in 293 cell line lysates (35ug/lane). This demonstrates the DEAF1 antibody detected the DEAF1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

2 Item(s)

per page
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