Defensin alpha 1 antibody

Principal name

Defensin alpha 1 antibody

Alternative names for Defensin alpha 1 antibody

Neutrophil defensin 1, HNP-1, DEFA1, DEF1, DEFA2, MRS

SwissProt ID

P07469 (Rabit), P11477 (Mouse), P59665 (Human), P81465 (Mesau)

Gene ID

1667 (DEFA1), 728358 (DEFA1B), 13216 (Defa1)

Available reactivities

Hu (Human), Bov (Bovine), Macaque, Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of Defensin alpha 1 antibody

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It differs from defensin, alpha 3 by only one amino acid.
Biological Functions: Various functions have been described for defensins. They are antibacterial, antifungal, chemotactic for monocytes, inhibitory for ACTH-induced corticosteroid synthesis and cytotoxic for cells. Defensins are inhibited by glucosaminoglycans (self protection for cells) and high concentrations of Ca2+ ions.

General readings

1. Stanfield, R.L. et al.: Characterization of Two Crystal Forms of Human Defensin Neutrophil Cationic Peptide 1, a Maturally Occurring Antimicrobial Peptide of Leukocytes. J. Biol. Chem. 263(12), 5933 - 5935 (1988).
2. Ganz, T. et al.: Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells. Med. Microbiol. Immunol. 181, 99 - 105 (1992).
3. Ganz, T. et al.: Defensins: Natural Peptide Antibiotics of Human Neutrophils. J. Clin. Invest. 76, 1427 - 1435 (1985).
4. ELSBACH,P.: Antibiotics from within: antibacterials from human and animal sources. TIBECH 8, (1990).
Daher, K.A. et al.: Isolation and characterization of human defensin cDNA clones. Proc. Natl. Acad. Sci. 85, 7327 - 7331, (1988).
5. Hill, C.P. et al.: Crystal Structure of Defensin HNP-3, an Amphilic Dimer: Mechanisms of Membrane Permeabilization. Science, 251, 1481 - 1485 (1991).
6. Selsted, M.E. et al.: Primary structures of Three Neutrophil Defensins. J. Clin. Invest. 76, 1436 - 1439, (1985).
7. Schluesener, H. & Meyermann, R.: Neutrophilic Defensins Penetrate the Blood Brain Barrier. J. Neurosc. Res. 42: 718-723 (1995).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Defensin alpha 1 (+Defensin alpha 3) antibody

AP23709PU-N DEFA1/3 antibody staining of paraffin embedded Human Thymus at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Defensin alpha 1 antibody

  Anti-DEFA1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human cervical and lung cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human cervical and lung cancer tissue using DEFA1 antibody at dilution 1/10, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

  Anti-DEFA1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human tonsil and ovarian tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human tonsil and ovarian tissue using DEFA1 antibody at dilution 1/10, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

  Anti-DEFA1 Rabbit Polyclonal Antibody  
Predicted band size: 10kDa.Positive control: Human lung tissue lysate.Recommended dilution: 1/500-1000 Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

  Anti-DEFA1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human liver cancer tissue. Recommended dilution: 1/5-20  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using DEFA1 antibody at dilution 1/10, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

  Biotinylated Anti-Human NP-1 Goat Polyclonal Antibody  
To detect hNP-1 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hNP-1. Goat IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

  Anti-Human NP-1 Goat Polyclonal Antibody  
To detect hNP-1 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human NP-1 (TA328407) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNP-1. Goat IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

  Rabbit Polyclonal Anti-DEFA1/3 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (DEFA1/3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

Immunohistochemistry analyzes of Defensin alpha-1 antibody (Cat.-No AP20627PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu P
0.1 mg / €350.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Mouse IgG1 B539M Purified Hu E, WB
1 mg / €840.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Goat Biotin Hu E
25 µg / €230.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Goat Biotin Hu E
50 µg / €340.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Goat Aff - Purified Hu E, FN, WB
50 µg / €230.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Goat Aff - Purified Hu E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

SM1382 Defensin antibody staining of Human Tonsil Paraffin Section. Mouse IgG1 DEF-3 Purified Hu C, P
0.1 mg / €530.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Mouse IgM B1F7 Purified Hu E, WB
1 mg / €630.00
  HyTest Ltd.

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Mouse IgG2b B4B6 Purified Hu E, WB
1 mg / €630.00
  HyTest Ltd.

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Mouse IgG1 D1C9 Purified Hu E, WB
1 mg / €630.00
  HyTest Ltd.

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Mouse IgG1 D1F4 Purified Hu WB
1 mg / €630.00
  HyTest Ltd.

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Mouse IgG1 D1H5 Purified Hu E, WB
1 mg / €630.00
  HyTest Ltd.

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