Defensin alpha 1 antibody

Principal name

Defensin alpha 1 antibody

Alternative names for Defensin alpha 1 antibody

Neutrophil defensin 1, HNP-1, DEFA1, DEF1, DEFA2, MRS

SwissProt ID

P07469 (Rabit), P11477 (Mouse), P59665 (Human), P81465 (Mesau)

Gene ID

1667 (DEFA1), 728358 (DEFA1B)

Available reactivities

Hu (Human), Bov (Bovine), Macaque, Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Defensin alpha 1 antibody

Nucleophosmin (NPM) also called B23, nutramin and NO38 is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. It is involved in the acute response of mammalian cells to environmental stress, such as UV rays. NPM continuously shuttles between the nucleus and cytoplasm. It has been shown to bind nucleic acid, prevent protein aggregation via its chaperon activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM is associated with the centrosome. It is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Due to the NPM gene interaction with several tumor associated chromosome translocations, NPM is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, it is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins.

General readings

1. Stanfield, R.L. et al.: Characterization of Two Crystal Forms of Human Defensin Neutrophil Cationic Peptide 1, a Maturally Occurring Antimicrobial Peptide of Leukocytes. J. Biol. Chem. 263(12), 5933 - 5935 (1988).
2. Ganz, T. et al.: Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells. Med. Microbiol. Immunol. 181, 99 - 105 (1992).
3. Ganz, T. et al.: Defensins: Natural Peptide Antibiotics of Human Neutrophils. J. Clin. Invest. 76, 1427 - 1435 (1985).
4. ELSBACH,P.: Antibiotics from within: antibacterials from human and animal sources. TIBECH 8, (1990).
Daher, K.A. et al.: Isolation and characterization of human defensin cDNA clones. Proc. Natl. Acad. Sci. 85, 7327 - 7331, (1988).
5. Hill, C.P. et al.: Crystal Structure of Defensin HNP-3, an Amphilic Dimer: Mechanisms of Membrane Permeabilization. Science, 251, 1481 - 1485 (1991).
6. Selsted, M.E. et al.: Primary structures of Three Neutrophil Defensins. J. Clin. Invest. 76, 1436 - 1439, (1985).
7. Schluesener, H. & Meyermann, R.: Neutrophilic Defensins Penetrate the Blood Brain Barrier. J. Neurosc. Res. 42: 718-723 (1995).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Defensin alpha 1 (+Defensin alpha 3) antibody

AP23709PU-N DEFA1/3 antibody staining of paraffin embedded Human Thymus at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu E, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Defensin alpha 1 antibody

Predicted cell location: Cytoplasm. Positive control: Human cervical and lung cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human cervical and lung cancer tissue using DEFA1 antibody at dilution 1/10, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

Predicted cell location: Cytoplasm. Positive control: Human tonsil and ovarian tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human tonsil and ovarian tissue using DEFA1 antibody at dilution 1/10, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

Predicted band size: 10kDa.Positive control: Human lung tissue lysate.Recommended dilution: 1/500-1000 Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

Predicted cell location: Cytoplasm . Positive control: Human liver cancer tissue. Recommended dilution: 1/5-20  The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using DEFA1 antibody at dilution 1/10, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

To detect hNP-1 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hNP-1. Goat IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

To detect hNP-1 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human NP-1 (TA328407) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNP-1. Goat IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Defensin alpha 1 antibody

Immunohistochemistry analyzes of Defensin alpha-1 antibody (Cat.-No AP20627PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu P
0.1 mg / €350.00
  Acris Antibodies GmbH

Defensin alpha 1 antibody

Defensin alpha 1 Mouse IgG2b 1B20 Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Defensin alpha 1 antibody

Defensin alpha 1 Goat Hu E, ICC/IF, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

Defensin alpha 1 antibody

Immunohistochemical analysis of Defensin alpha 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Defensin alpha 1 antibody

Immunohistochemical analysis of Defensin alpha 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Defensin alpha 1 antibody

Immunohistochemical analysis of Defensin alpha 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Defensin alpha 1 antibody

Defensin alpha 1 Goat Aff - Purified Hu E, WB
0.1 mg / €470.00
  Novus Biologicals Inc.

Defensin alpha 1 antibody

Defensin alpha 1 Rabbit IgG Aff - Purified Hu P, WB
0.1 mg / €470.00
  Novus Biologicals Inc.

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Mouse IgG1 B539M Purified Hu E, WB
1 mg / €780.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Goat Biotin Hu E
25 µg / €230.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Goat Biotin Hu E
50 µg / €340.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Goat Aff - Purified Hu E, FN, WB
50 µg / €230.00
  Acris Antibodies GmbH

Defensin alpha 1-3 antibody

Defensin alpha 1-3 Goat Aff - Purified Hu E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

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