Defensin beta 3 antibody

Principal name

Defensin beta 3 antibody

Alternative names for Defensin beta 3 antibody

DEFB103A, DEFB103B, BD3, DEFB3, HBP3, HBD3, DEFB103, Beta-defensin 103, Defensin-like protein, Defensin beta 103

SwissProt ID

P81534 (Human), Q0W9P9 (Horse)

Gene ID

414325 (DEFB103A), 55894 (DEFB103B)

Available reactivities

Bac (Bacteria), Hu (Human), Rt (Rat), Ms (Mouse)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Radioimmunoassay (R), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Defensin beta 3 antibody

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.

General readings

Wu Q, Gui P, Yao S, Zhu H, Li J, Li Y (2010). Expression of beta-Defensin-3 in Lungs of Immunocompetent Rats with Methicillin-Resistant Staphylococcus aureus Ventilator-Associated Pneumonia. J Surg Res [Epub ahead of print

  • LinkedIn