Delta-like protein 1 antibody

Principal name

Delta-like protein 1 antibody

Alternative names for Delta-like protein 1 antibody

DLL1, Drosophila Delta homolog 1, Delta1, H-Delta-1

SwissProt ID

O00548 (Human), P97677 (Rat), Q61483 (Mouse)

Gene ID

28514 (DLL1), 13388 (Dll1), 84010

Available reactivities

Hu (Human), Ms (Mouse), Chk (Chicken), Rt (Rat), Bov (Bovine), African clawed frog, Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat, Hamster

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of Delta-like protein 1 antibody

Human soluble DLL-1 comprises the extracellular signaling domain of DLL-1, a member of the Delta/Serrate/Lag-2 (DSL) family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed primarily in the heart, pancreas and epidermis. DLL-1 functions to specifically activate the Notch-1 and Notch-2 receptors. Proteolytic cleavage of DLL-1 produces a secreted extracellular domain, sDLL-1, that interacts with Notch receptors expressed on adjacent cells. Notch signaling plays an essential role in controlling cell fate decisions during prenatal development and postnatal stem cell renewal, and differentiation in many tissues. Human sDLL-1 blocks monocyte differentiation into macrophages, but permits differentiation into dendritic cells. In hematopoietic progenitor cells, hsDLL-1, suppresses differentiation into B-cells, while promoting differentiation into T-cells and NK cell precursors. In cell culture, human sDLL-1 has been shown to promote expansion of hematopoietic progenitor cells and suppress apoptosis by inhibiting differentiation. Overexpression of Notch receptors appears to inhibit differentiation in several mammalian cell lines, and increasing evidence suggests that Notch signaling is frequently downregulated in human malignancies. The human DLL-1 gene consists of a 528 amino acid extracellular domain with one DSL domain, eight EGF-like repeats, a 23 amino acid transmembrane domain, and a 155 amino acid cytoplasmic domain. The calculated molecular weight of Recombinant Human sDLL-1 is 56.3 kDa.

General readings

Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D.
MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.
2008 Mar 2 (3): 219-29.
PMID: 18371447

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Delta-like protein 1 antibody

  Goat Anti-DLL1 Antibody  
TA305657 (0.3ug/ml) staining of Rat Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Delta-like protein 1 antibody

  Hamster Anti-Mouse DLL1 (delta-like 1) Purified (100 ug)  
Staining of Delta-like 1-transfected CHO cells with 0.25 ug of Armenian Hamster IgG Isotype Control Purified (blue histogram) or 0.25 ug of Anti-Mouse DLL1 (delta-like 1) Purified (purple histogram).  Total viable cells were used for analysis. Hamster HMD1-5 Purified Ms F, P
0.1 mg / €150.00
  OriGene Technologies, Inc.

Delta-like protein 1 antibody

  Rabbit Polyclonal Anti-DLL1 Antibody  
WB Suggested Anti-DLL1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Delta-like protein 1 (155-173) antibody

Figure 1. Staining DLL1 (Delta-1) in Brain by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Aff - Purified Hu, Ms E, P
50 µg / €470.00
  Acris Antibodies GmbH

Delta-like protein 1 (155-173) antibody

Delta-like protein 1 Rabbit IgG Aff - Purified Chk, Hu, Ms, Rt E
0.1 mg / €450.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

DLL1 - human gene knockout kit via CRISPR

DLL1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DLL1 - human gene knockout kit via CRISPR

DLL1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DLL1 - human gene knockout kit via CRISPR

DLL1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DLL1 - human gene knockout kit via CRISPR

DLL1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dll1 - mouse gene knockout kit via CRISPR

Dll1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Dll1 - mouse gene knockout kit via CRISPR

Dll1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dll1 - mouse gene knockout kit via CRISPR

Dll1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dll1 - mouse gene knockout kit via CRISPR

Dll1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Delta-like protein 1

  Recombinant protein of human delta-like 1 (Drosophila) (DLL1)  
Delta-like protein 1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Delta-like protein 1

  Purified recombinant protein of Human delta-like 1 (Drosophila) (DLL1).  
Delta-like protein 1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 25 µg / €399.00

Special Price: 25 µg / €239.00

  OriGene Technologies, Inc.

Delta-like protein 1

Delta-like protein 1 Human Purified > 95 % pure by SDS-PAGE and HPLC analyses HEK293 cells
25 µg / €230.00
  Acris Antibodies GmbH

Delta-like protein 1

Delta-like protein 1 Human Purified > 95 % pure by SDS-PAGE and HPLC analyses HEK293 cells
5 µg / €140.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

DLL1 overexpression lysate

DLL1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DLL1 (Myc-DDK tagged) - Human delta-like 1 (Drosophila) (DLL1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, DLL1 (Myc-DDK tagged) - Human delta-like 1 (Drosophila) (DLL1) , 200 uL, >10^7 TU/mL  
200 µl / €1,440.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dll1 (GFP-tagged) - Mouse delta-like 1 (Drosophila) (Dll1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dll1 (GFP-tagged) - Mouse delta-like 1 (Drosophila) (Dll1), 200 uL, >10^7 TU/mL  
200 µl / €1,410.00
  OriGene Technologies, Inc.

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