Deoxyguanosine kinase antibody

Principal name

Deoxyguanosine kinase antibody

Alternative names for Deoxyguanosine kinase antibody

DGUOK, DGK

SwissProt ID

Q16854  (Human), Q9QX60 (Mouse)

Gene ID

1716 (DGUOK)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP)

Background of Deoxyguanosine kinase antibody

Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Mitochondrial DNA depletion syndromes are phenotypically heterogeneous, autosomal recessive disorders characterized by tissue-specific reduction in mtDNA copy number. Affected individuals with the hepatocerebral form of mtDNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Deoxyguanosine kinase antibody

WB Suggested Anti-DGUOK Antibody; Titration: 1.0 ug/ml; Positive Control: 721_B Whole Cell DGUOK is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Deoxyguanosine kinase (N-term) antibody

Western blot analysis of anti-DGUOK Pab in mouse kidney tissue lysate (35ug/lane). DGUOK(arrow) was detected using the purified Pab (1:60 dilution). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Deoxyguanosine kinase (C-term) antibody

The anti-DGUOK Pab is used in Western blot to detect DGUOK in mouse thymus tissue lysate (Lane 1) and K562 cell lysate (Lane 2). Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Deoxyguanosine kinase antibody

Western blot analysis of DGUOK over-expressed 293 cell line, cotransfected with DGUOK Validated Chimera RNAi ( Cat # H00001716-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with DGUOK monoclonal antibody (M02), clone 3E9 (Cat # H00001716-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control. Mouse IgG1 3E9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Deoxyguanosine kinase antibody

Deoxyguanosine kinase Mouse IgG2a 4E5 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Deoxyguanosine kinase antibody

Western blot analysis of DGUOK polyclonal antibody ( Cat # PAB4644 ) in mouse kidney tissue lysate ( 35 µg/lane ) . DGUOK ( arrow ) was detected using the purified DGUOK polyclonal antibody ( Cat # PAB4644 ) ( 1 : 60 dilution ) . Rabbit Hu, Ms E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Deoxyguanosine kinase antibody

The DGUOK polyclonal antibody ( Cat # PAB4645 ) is used in Western blot to detect DGUOK in mouse thymus tissue lysate . Rabbit Hu, Ms E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Deoxyguanosine kinase antibody

Immunohistochemistry-Paraffin: Deoxyguanosine kinase Antibody [NBP1-84256] - Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Deoxyguanosine kinase (transcript variant 1)

Deoxyguanosine kinase Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Deoxyguanosine kinase

Deoxyguanosine kinase Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

Deoxyguanosine kinase

Deoxyguanosine kinase Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Deoxyguanosine kinase

Deoxyguanosine kinase Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

12 Item(s)

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