Deoxyribonuclease-1 antibody

Principal name

Deoxyribonuclease-1 antibody

Alternative names for Deoxyribonuclease-1 antibody

DNASE1, DNL1, DRNI, Deoxyribonuclease I, DNase I

SwissProt ID

O18998 (Rabit), P00639 (Bovin), P11936 (Pig), P11937 (Sheep), P21704 (Rat), P24855 (Human), P49183 (Mouse), Q4AEE3 (Horse), Q767J3 (Canfa), Q9YGI5 (Chick)

Gene ID

282217 (DNASE1), 1773, 13419 (Dnase1), 25633

Available reactivities

Bov (Bovine), Hu (Human), Can (Canine), Rb (Rabbit), Rt (Rat), Ms (Mouse)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Dot blot (Dot), Immunodiffusion (ID), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Radioimmunoassay (R), Paraffin Sections (P)

Background of Deoxyribonuclease-1 antibody

Deoxyribonuclease I (EC 3.1.21.1) gene is approximately 3.2 kb long with 9 exons separated by 8 introns. In the form of a bovine pancreatic enzyme preparation, it occupies an important place in the history of protein chemistry and enzymology: it was the first enzyme to be recognized as specific for DNA; it was the first DNase to be crystallized; and it was the first DNase for which a specific protein inhibitor was characterized.

DNase I is a Ca2+ and Mg2+ dependant endonuclease. DNase I is synthesized in the pancreas and stored in zymogen granules. It has been used to reduce the viscosity of cystic fibrosis sputum. A DNase I-like enzyme appears to catalyze the degradation of chromatin to oligo- and mononucleosomes during apoptosis. A recent study has demonstrated an endonuclease with activity and antigenicity indistinguishable from DNase I in thymocytes, cells susceptible to apoptosis. DNase I is an endonuclease that hydrolyzes double-stranded or single stranded DNA preferentially at sites adjacent to pyrimidine nucleotides. The product of hydrolysis is a complex mixture of 5'-phosphate mononucleotides and oligonucleotides. In the presence of Mg ion, DNase I attacks each strand of DNA independently and the cleavage sites are random.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Deoxyribonuclease-1 antibody

  Rabbit Polyclonal antibody to DNase I (deoxyribonuclease I)  
Sample (30 ug of whole cell lysate). A: MOLT4 . 10% SDS PAGE. TA308546 diluted at 1:1000 Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Deoxyribonuclease-1 antibody

  Rabbit Polyclonal Anti-DNASE1 Antibody  
WB Suggested Anti-DNASE1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: PANC1 cell lysate.DNASE1 is supported by BioGPS gene expression data to be expressed in PANC1 Rabbit IgG Purified Bov, Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Deoxyribonuclease-1 antibody

  Rabbit Polyclonal Anti-DNASE1 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using (DNASE1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Deoxyribonuclease-1 antibody

Western Blot testing of anti-bovine DNaseI monoclonal antibody (7B12). Line 1: PageRuler Prestained Protein Ladder (#SM0671 Fermentas); Line 2: Recombinant bovine DNaseI expressed into the supernatant of CHO cell culture medium. 10 µl of cell culture supernatant was loaded into the gel. Mouse IgG1 7B12 Aff - Purified Bov, Hu E, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Deoxyribonuclease-1 antibody

Western Blot testing of anti-bovine DNaseI monoclonal antibody (6D5). Line 1: PageRuler Prestained Protein Ladder (#SM0671 Fermentas); Line 2: Recombinant bovine DNaseI expressed into the supernatant of CHO cell culture medium. 10 µl of cell culture supernatant was loaded into the gel. Mouse IgG1 6D5 Aff - Purified Bov, Hu E, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Deoxyribonuclease-1 antibody

Western Blot testing of anti-Bovine DNaseI monoclonal antibody (4B10). Line 1: PageRuler Prestained Protein Ladder (#SM0671 Fermentas); Line 2: Recombinant bovine DNaseI expressed into the supernatant of CHO cell culture medium. 10 µl of cell culture supernatant was loaded into the gel. Mouse IgG1 4B10 Aff - Purified Bov, Hu E, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Deoxyribonuclease-1 antibody

Deoxyribonuclease-1 Rabbit IgG Aff - Purified Bov Dot, E, ICC/IF, ID, IP, R, WB
1 mg / €440.00
  Acris Antibodies GmbH

Deoxyribonuclease-1 (1-252) antibody

Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Deoxyribonuclease-1 antibody

Deoxyribonuclease-1 Rabbit Serum Bov E, WB
2 ml / €1,180.00
  Acris Antibodies GmbH

Deoxyribonuclease-1 antibody

Deoxyribonuclease-1 Rabbit Biotin Bov E, IP, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

Deoxyribonuclease-1 antibody

Deoxyribonuclease-1 Rabbit HRP Bov E, IP, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

Deoxyribonuclease-1 antibody

Deoxyribonuclease-1 Rabbit Ig Fraction Bov E, IP, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Dnase1 - mouse gene knockout kit via CRISPR

Dnase1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Dnase1 - mouse gene knockout kit via CRISPR

Dnase1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dnase1 - mouse gene knockout kit via CRISPR

Dnase1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dnase1 - mouse gene knockout kit via CRISPR

Dnase1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

DNASE1 overexpression lysate

DNASE1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DNASE1 (mGFP-tagged) - Human deoxyribonuclease I (DNASE1), 200 uL, >10^7 TU/mL

Lenti ORF particles, DNASE1 (mGFP-tagged) - Human deoxyribonuclease I (DNASE1), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, DNASE1 (Myc-DDK tagged) - Human deoxyribonuclease I (DNASE1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, DNASE1 (Myc-DDK tagged) - Human deoxyribonuclease I (DNASE1) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dnase1 (GFP-tagged ORF) - Rat deoxyribonuclease I (Dnase1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dnase1 (GFP-tagged ORF) - Rat deoxyribonuclease I (Dnase1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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