Desert hedgehog / DHH antibody

Principal name

Desert hedgehog / DHH antibody

Alternative names for Desert hedgehog / DHH antibody


SwissProt ID

O43323 (Human), Q61488 (Mouse)

Gene ID

13363 (Dhh), 50846 (DHH)

Available reactivities

Ms (Mouse), Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Gt (Goat), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Ze (Zebrafish)

Available hosts

Goat, Rat, Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of Desert hedgehog / DHH antibody

Desert Hedgehog (Dhh) belongs to the highly conserved Hedgehog family of proteins which are involved in multiple developmental processes. Hedgehogs are synthesized as 45 kDa precursors that are cleaved autocatalytically. The 19 kDa Nterminal fragment remains membrane associated due to its cholesterol and palmitate modifications. Binding of this fragment to Patched receptors results in the loss of Patched repression of Smoothened signaling. Dhh binds both Patched and Patched 2 as well as Hedgehog interacting protein (Hip). Within the N-terminal peptide, mouse Dhh shares 97% and 100% amino acid (aa) sequence identity with human and rat Dhh, respectively. It shares 74% aa seqeuence identity with mouse Indian (Ihh) and Sonic hedgehog (Shh). Dhh is produced by Sertoli cells and is required for testis development and spermatogenesis. It induces steroidogenic factor 1 which is instrumental in promoting Leydig cell differentiation. It also promotes the deposition of basal lamina surrounding seminiferous tubules. In humans, mutations of Dhh are associated with pure gonadal dysgenesis. Dhh is expressed in the female by ovarian granulosa cells and the corpus luteum. Its upregulation in human ovarian cancer correlates positively with proliferative index and negatively with prognosis. Dhh is also expressed by Schwann cells and is upregulated following nerve injury. It induces the expression of Patched and Hip in nerve fibroblasts and promotes the formation of the connective tissue sheath surrounding peripheral nerves.

General readings

Chen YJ, et al. (2007). Cell Cycle. 6(15):1826-30.Van den Brink GR., et al. (2007). Physiol Rev. 87(4):1343-75

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Desert hedgehog / DHH antibody

  Rabbit Polyclonal Anti-DHH Antibody  
Host: Rabbit; Target Name: Dhh; Sample Tissue: Mouse Kidney lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
0.1 ml / €360.00
  OriGene Technologies, Inc.

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