Desmin antibody

Principal name

Desmin antibody

Alternative names for Desmin antibody

DES

SwissProt ID

O62654 (Bovin), P02540 (Pig), P02541 (Mesau), P02542 (Chick), P17661 (Human), P23239 (Xenla), P31001 (Mouse), P48675 (Rat), Q5XFN2 (Canfa)

Gene ID

1674 (DES), 64362 (Des), 13346

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Chk (Chicken), African clawed frog, Mam (Mammalia), Hst (Hamster), Ze (Zebrafish), Gt (Goat), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Desmin antibody

Desmins belongs to the intermediate filament family, and are class III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin antibodies are useful in identification of tumours of myogenic origin.

General readings

Chen F, Chang R, Trivedi M, Capetanaki Y, Cryns VL.
Caspase proteolysis of desmin produces a dominant-negative inhibitor of intermediate filaments and promotes apoptosis.
J Biol Chem. 2003 Feb 28;278(9):6848-53.
PMID: 12477713

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Desmin (C-term) antibody

Human skeletal muscle stained with anti-Desmin antibody Rabbit IgG SP138 Purified Bov, Can, Hu, Ms, Por, Rt P, WB
0.5 ml / €520.00
  Acris Antibodies GmbH

Desmin (C-term) antibody

Human skeletal muscle stained with anti-Desmin antibody Rabbit IgG SP138 Purified Bov, Can, Hu, Ms, Por, Rt P, WB
1 ml / €750.00
  Acris Antibodies GmbH

Desmin (C-term) antibody

Human skeletal muscle stained with anti-Desmin antibody Rabbit IgG SP138 Purified Bov, Can, Hu, Ms, Por, Rt P, WB
0.1 ml / €300.00
  Acris Antibodies GmbH

Desmin antibody

Immunohistochemical staining of paraffin-embedded Human adult heart tissue using anti-DES mouse monoclonal antibody. (UM500107, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB166 Purified Hu P
0.1 ml / €379.00
  OriGene Technologies, Inc.

UltraMAB

Desmin antibody

Immunohistochemical staining of paraffin-embedded Human adult heart tissue using anti-DES mouse monoclonal antibody. (UM500107, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB166 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Desmin antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-DES mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502328) Mouse IgG1 OTI4G1 Purified Hu F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Desmin (C-term) antibody

Desmin expression detected in the uterine leiomyoma tissue with DB 148 monospecific antibody.Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG E18-V Aff - Purified Hu P
0.1 ml / €270.00
  DB Biotech, spol. s r.o.

Sample sizes available

Desmin (C-term) antibody

Desmin expression detected in the uterine leiomyoma tissue with DB 148 monospecific antibody.Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG E18-V Aff - Purified Hu P
0.2 ml / €360.00
  DB Biotech, spol. s r.o.

Sample sizes available

Desmin (C-term) antibody

Desmin expression detected in the uterine leiomyoma tissue with DB 148 monospecific antibody.Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG E18-V Aff - Purified Hu P
0.5 ml / €460.00
  DB Biotech, spol. s r.o.

Sample sizes available

Desmin (C-term) antibody

Desmin expression detected in the uterine leiomyoma tissue with DB 148 monospecific antibody.Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG E18-V Aff - Purified Hu P
1 ml / €700.00
  DB Biotech, spol. s r.o.

Sample sizes available

Desmin antibody

Desmin antibody staining of Human skeletal muscle Rabbit Purified Hu, Ms, Rt IP, P, WB
0.5 ml / €310.00
  Acris Antibodies GmbH

Desmin antibody

Desmin antibody staining of Human skeletal muscle Rabbit Purified Hu, Ms, Rt IP, P, WB
1 ml / €420.00
  Acris Antibodies GmbH

Desmin antibody

Desmin antibody staining of Human skeletal muscle Rabbit Purified Hu, Ms, Rt IP, P, WB
0.1 ml / €170.00
  Acris Antibodies GmbH

Desmin (C-term) antibody

TA305636 (0.5 ug/ml) staining of Pig (A), Mouse (B) and Rat (C) Skeletal Muscle lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Desmin antibody

Western blot analysis of extracts from K562 cells, using Desmin antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Desmin antibody

  Mouse Monoclonal Desmin Antibody  
Immunohistochemistry staining of Paraffin Muscle tissue by Desmin antibody (dilution: 1:25 - 1:100; visualization of staining: Cytoplasmic) Mouse IgG1 D33 Purified Hu P
1 ml / €600.00
  OriGene Technologies, Inc.

Desmin antibody

WB Suggested Anti-DES Antibody Titration: 5.0 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Desmin antibody

WB Suggested Anti-DES Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Desmin antibody

Western blot analysis on HeLa cell lysate using Desmin Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Desmin antibody

AM06010PU-N Desmin Antibody staining of Formalin-Fixed Paraffin-Embedded Human Skeletal muscle at 1/1000-1/2000 followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 10H7D2 Purified Hu C, E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

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