Desmin antibody

Principal name

Desmin antibody

Alternative names for Desmin antibody

DES

SwissProt ID

O62654 (Bovin), P02540 (Pig), P02541 (Mesau), P02542 (Chick), P17661 (Human), P23239 (Xenla), P31001 (Mouse), P48675 (Rat), Q5XFN2 (Canfa)

Gene ID

1674 (DES)

Available reactivities

Can (Canine), Chk (Chicken), Hst (Hamster), Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), Rb (Rabbit), Ze (Zebrafish), Mam (Mammalia), Bov (Bovine), Fe (Feline), Gt (Goat), Sh (Sheep), Snake, L (Lizard), Mky (Monkey), Bab (Baboon), Re (Reptiles), African clawed frog, Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of Desmin antibody

The cytoskeleton consists of three types of cytosolic fibers: microfilaments (actin filaments), intermediate filaments and microtubules. Major types of intermediate filaments are distinguished and expressed in particular cell types: cytokeratins (epithelial cells), glial fibrillary acidic protein or GFAP (glial cells), desmin (skeletal, visceral and certain vascular smooth muscle cells), vimentin (mesenchyme origin) and neurofilaments (neurons). GFAP and vimentin form intermediate filaments in astroglial cells and modulate their motility and shape. In particular, vimentin filaments are present at early developmental stages, while GFAP filaments are characteristic of differentiated and mature brain astrocytes. Thus, GFAP is commonly used as a marker for intracranial and intraspil tumors arising from astrocytes. Vimentin is present in sarcomas, but not carcinomas, and its expression is examined relative to other markers to distinguish between the two forms of neoplasm. Desmin is a myogenic marker expressed in early development that forms a network of filaments that extends across the myofibril and surrounds Z discs. The desmin cytoskeleton provides a connection among myofibrils, organelles and the cytoskeleton. Desmin knockout mice develop cardiomyopathy, skeletal and smooth muscle defects. In humans, desmin related myopathies might be caused by mutations in the corresponding desmin gene or in proteins with which desmin interacts, including ¦ÁB-crystallin and synemin. Disorganized desmin filaments and the accumulation of protein aggregates comprised predomintly of desmin characterize desmin-related myopathies.

General readings

Exp Biol Med (Maywood). 2002 Dec;227(11):1039-46.
Protein kinase C-mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart.
Huang X, Li J, Foster D, Lemanski SL, Dube DK, Zhang C, Lemanski LF.
Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL 33431, USA

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Desmin (C-term) antibody

Human skeletal muscle stained with anti-Desmin antibody Rabbit IgG SP138 Purified Bov, Can, Hu, Ms, Por, Rt P, WB
0.5 ml / €510.00
  Acris Antibodies GmbH

Desmin (C-term) antibody

Human skeletal muscle stained with anti-Desmin antibody Rabbit IgG SP138 Purified Bov, Can, Hu, Ms, Por, Rt P, WB
1 ml / €730.00
  Acris Antibodies GmbH

Desmin (C-term) antibody

Human skeletal muscle stained with anti-Desmin antibody Rabbit IgG SP138 Purified Bov, Can, Hu, Ms, Por, Rt P, WB
0.1 ml / €290.00
  Acris Antibodies GmbH

Desmin antibody

Immunohistochemical staining of paraffin-embedded Human adult heart tissue using anti-DES mouse monoclonal antibody. (UM500107, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB166 Purified Hu P
0.1 ml / €379.00
  OriGene Technologies, Inc.

UltraMAB

Desmin antibody

Immunohistochemical staining of paraffin-embedded Human adult heart tissue using anti-DES mouse monoclonal antibody. (UM500107, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB166 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Desmin antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-DES mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502328) Mouse IgG1 OTI4G1 Purified Hu F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Desmin (C-term) antibody

Desmin expression detected in the uterine leiomyoma tissue with DB 148 monospecific antibody.Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG E18-V Aff - Purified Hu P
0.1 ml / €270.00
  DB Biotech, spol. s r.o.

Sample sizes available

Desmin (C-term) antibody

Desmin expression detected in the uterine leiomyoma tissue with DB 148 monospecific antibody.Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG E18-V Aff - Purified Hu P
0.2 ml / €360.00
  DB Biotech, spol. s r.o.

Sample sizes available

Desmin (C-term) antibody

Desmin expression detected in the uterine leiomyoma tissue with DB 148 monospecific antibody.Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG E18-V Aff - Purified Hu P
0.5 ml / €460.00
  DB Biotech, spol. s r.o.

Sample sizes available

Desmin (C-term) antibody

Desmin expression detected in the uterine leiomyoma tissue with DB 148 monospecific antibody.Kindly performed and provided by Marián Švajdler, MD and Dr. Lucia Fröhlichová, from Louis Pasteur University Hospital Department of Pathology, Košice, Slovak Republic. Rabbit IgG E18-V Aff - Purified Hu P
1 ml / €700.00
  DB Biotech, spol. s r.o.

Sample sizes available

Desmin antibody

Desmin antibody staining of Human skeletal muscle Rabbit Purified Hu, Ms, Rt IP, P, WB
0.5 ml / €300.00
  Acris Antibodies GmbH

Desmin antibody

Desmin antibody staining of Human skeletal muscle Rabbit Purified Hu, Ms, Rt IP, P, WB
1 ml / €410.00
  Acris Antibodies GmbH

Desmin antibody

Desmin antibody staining of Human skeletal muscle Rabbit Purified Hu, Ms, Rt IP, P, WB
0.1 ml / €170.00
  Acris Antibodies GmbH

Desmin (C-term) antibody

TA305636 (0.5 ug/ml) staining of Pig (A), Mouse (B) and Rat (C) Skeletal Muscle lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Desmin antibody

Western blot analysis of extracts from K562 cells, using Desmin antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Desmin antibody

Immunohistochemistry staining of Paraffin Muscle tissue by Desmin antibody (dilution: 1:25 - 1:100; visualization of staining: Cytoplasmic) Mouse IgG1 D33 Purified Hu P
1 ml / €430.00
  OriGene Technologies, Inc.

Desmin antibody

WB Suggested Anti-DES Antibody Titration: 5.0 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Desmin antibody

WB Suggested Anti-DES Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Desmin antibody

Western blot analysis on HeLa cell lysate using Desmin Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Desmin antibody

AM06010PU-N Desmin Antibody staining of Formalin-Fixed Paraffin-Embedded Human Skeletal muscle at 1/1000-1/2000 followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 10H7D2 Purified Hu C, E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

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