Desmoglein-3 antibody

Principal name

Desmoglein-3 antibody

Alternative names for Desmoglein-3 antibody

DSG3, CDHF6, PVA, 130 kDa pemphigus vulgaris antigen, Cadherin family member 6

SwissProt ID

O35902 (Mouse), P32926 (Human), Q7YRU7 (Canfa)

Gene ID

1830 (DSG3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of Desmoglein-3 antibody

Chemokines bind to specific G protein-coupled cell surface receptors on target cells. Five CXC receptors (CXCR1-5), nine CC receptors (CCR1-9) and one CXXXC receptor (CX3CR1) have been cloned to date. Expression of chemokine receptors can be restricted to some cell types (CXCR1 is expressed in neutrophils) while others (such as CCR2) are expressed in a wide variety of cells. Receptor expression has also been found to be constitutive (including down regulation), inducible or restricted to a cell state of activation. In addition, some chemokine receptors are also expressed in non-hematopoietic cells, such as nerve, endothelial and epithelial cells. This suggests that chemokines have other roles besides leucocyte chemotaxis. CX3CR1, for example, is highly expressed in adult brain. Chemokine receptors are linked to phospholipases through the Gi class of G proteins (inhibition by pertussis toxin). Receptor activation leads to a cascade of cellular events including generation of inositol triphosphate, calcium release and activation of protein kinase C. Chemokine receptors also activate small GTP-binding proteins of the Ras and Rho families, the latter being involved in cell motility events. In addition, chemokines bind to non-signaling molecules such as the Duffy antigen receptor for chemokines (DARC) which may act to remove chemokines from the circulation, and heparan sulfates proteoglycans which may serve to establish an ECM concentration gradient. CXCR-1 (IL-8RA, or type I IL-8 receptor) and CXCR-2 (IL-8RB, or type II IL-8 receptor) have been shown to share approximately 77% amino acid sequence identity. IL-8 binds to both receptors with high affinity and induces rapid elevation of cytosolic Ca2+ levels. Whereas CXCR-1 is highly specific for IL-8, CXCR-2 has broad specificity and has been shown to bind with high-affinity to other ELR motif containing a chemokines including GRO", GRO, GRO(, NAP-2 and ENA-78. In contrast, PF4 and IP-10 (two chemokines that lack the ELR motif) have been shown to lack binding affinity for CXCR-2. CXCR-1 and CXCR-2 are expressed by neutrophils but not B lymphocytes or T lymphocytes.

General readings

Baican, A., et al. Int. J. Dermatol. 49(7):768-774(2010)
Jolly, P.S., et al. J. Biol. Chem. 285(12):8936-8941(2010)
Capon, F., et al. Br. J. Dermatol. 161(6):1403-1405(2009)
Aoyama, Y., et al. Exp. Dermatol. 18(4):404-408(2009)
Latourelle, J.C., et al. BMC Med. Genet. 10, 98 (2009)

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Desmoglein-3 antibody

Immunocytochemistry: Desmoglein 3 Antibody (5H10) - Desmoglein 3 (5H10) antibody was tested in oral HNSCC cells fixed with 1% formaldehyde permeabilized in 0.1% triton x-100. Mouse IgG1 5H10 Purified Hu C, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Desmoglein-3 antibody

Immunohistochemistry: Desmoglein 3 Antibody (5G11) - Immunohistochemical analysis of Desmoglein 3 on human skin cancer. The antibody was used at a dilution of 1:200. Mouse IgG1 5G11 Purified Hu C, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Desmoglein-3 antibody

WB Suggested Anti-DSG3 Antibody; Titration: 1.0 ug/ml; Positive Control: HepG2 Whole Cell Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Desmoglein-3 (N-term) antibody

Western blot analysis of Desmoglein-3 Antibody (N-term) Cat.-No AP51324PU-N in WiDr cell line lysates (35ug/lane). This demonstrates the DSG3 antibody detected the DSG3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Desmoglein-3 antibody

Desmoglein-3 Mouse IgG1 Dsg-G194 Supernatant Hu C, WB
5 ml / €290.00
  Acris Antibodies GmbH

Desmoglein-3 antibody

Desmoglein-3 Mouse IgG1 5G11 Purified Hu C, ICC/IF, IP, P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Desmoglein-3 (C-term) antibody

Human HepG2; WB Suggested Anti-DSG3 Antibody. . Titration: 1.0 ug/ml. . Positive Control: HepG2 Whole Cell; DSG3 antibody - C-terminal region (ARP61265_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Desmoglein-3 antibody

Desmoglein-3 Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

Desmoglein-3 antibody

Western blot analysis of Desmoglein 3 expression in A431 (A); HeLa (B); Raw264.7 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Desmoglein-3 antibody

Western blot analysis of Desmoglein 3 expression in A431 (A); HeLa (B); Raw264.7 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Desmoglein-3 antibody

Western blot analysis of Desmoglein 3 expression in A431 (A); HeLa (B); Raw264.7 (C); PC12 (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Desmoglein-3 antibody

Desmoglein-3 Mouse IgG1 5G11 Purified Hu ICC/IF, IP, P, WB
25 µl / €200.00
  Novus Biologicals Inc.

12 Item(s)

per page
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