Desmoplakin antibody

Principal name

Desmoplakin antibody

Alternative names for Desmoplakin antibody

DP, DSP, 250/210 kDa paraneoplastic pemphigus antigen

SwissProt ID

P15924 (Human)

Gene ID

1832 (DSP)

Available reactivities

Amph (Amphibian), Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Xen (Xenopus), Fi (Fish), Ze (Zebrafish)

Available hosts

Mouse, Guinea Pig, Rabbit, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Desmoplakin antibody

Desmosomes are intercellular junctions that form tight links between adjacent cells. Desmoplakin is an obligate component of functional desmosomes that attaches intermediate filaments to desmosomal plaques. It is involved in the organization of desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains. The N-terminus of desmoplakin is essential for localisation to the desmosome and interaction with plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds to intermediate filaments. The central region of desmoplakin comprises a coiled-coil rod domain that mediates homodimerisation. There are two isoforms of desmoplakin - desmoplakin I, which is an obligate component of all desmosomes, and desmoplakin II, which is predominantly expressed in tissues and cells of stratified origin. Mutations in the gene encoding desmoplakin result in a number of cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Desmoplakin (C-term) antibody

Desmoplakin Mouse IgG2b DPI/II 236.23.1 Supernatant Bov, Hu, Ms, Xen C, ICC/IF, P, WB
5 ml / €290.00
  Acris Antibodies GmbH

Desmoplakin antibody

Desmoplakin Rabbit IgG Purified Hu
50 µg / €325.00
  OriGene Technologies, Inc.

Desmoplakin (2115-2132) antibody

Desmoplakin Mouse IgG1 DP447 Supernatant Bov, Chk, Fi, Hu, Ms, Xen, Ze C, ICC/IF, P, WB
5 ml / €290.00
  Acris Antibodies GmbH

Desmoplakin (1672 -1684) antibody

Desmoplakin antibody Cat.-No AP31969PU-N staining of paraffin embedded Human Heart at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €340.00
  Acris Antibodies GmbH

Desmoplakin antibody

Desmoplakin Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Desmoplakin (DP1+DP2) antibody

Desmoplakin Mouse IgG1 DP2.15 Purified Amph, Bov, Can, Chk, Hu, Ms, Rt C, ICC/IF, WB
50 µg / €310.00
  Acris Antibodies GmbH

Desmoplakin antibody

Desmoplakin Mouse IgG1 DP-2.17 Purified Bov, Chk, Hu, Ms, Rt C, P, WB
50 µg / €300.00
  Acris Antibodies GmbH

Desmoplakin antibody

Desmoplakin Guinea Pig Serum Bov, Hu C, P, WB
50 µl / €350.00
  Acris Antibodies GmbH

Desmoplakin antibody

Desmoplakin Rabbit Hu E, P, WB
50 µg / €500.00
  Novus Biologicals Inc.

9 Item(s)

per page
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