Destrin antibody

Principal name

Destrin antibody

Alternative names for Destrin antibody

DSTN, ACTDP, DSN, ADF, Actin-depolymerizing factor

SwissProt ID

P18359 (Chick), P60981 (Human), P60982 (Pig), Q5E9D5 (Bovin), Q7M0E3 (Rat), Q9R0P5 (Mouse)

Gene ID

11034 (DSTN)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Chk (Chicken), Por (Porcine), African clawed frog, Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F)

Background of Destrin antibody

Actin-depolymerizing factor (ADF), also known as destrin, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. The Actin-depolymerizing activity of ADF is reversibly controlled by changes in KCl concentration but is insensitive to calcium concentration. ADF depolymerizes F-Actin by interacting directly with F-Actin protomers. ADF shares 71% sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. The difference in the function of ADF and Cofilin results from the subtle difference in their amino acid sequence rather than possible differences in posttranslational modifications. As a result of different cleavage sites on ADF and Cofilin, the proteins differ in their overall tertiary folds. Sensitivity to polyphosphoinositides may be a common feature in vitro among Actin-binding proteins such as ADF and Cofilin that can bind to G-Actin and regulate the state of Actin polymerization. ADF and Cofilin are Actin-depolymerizing proteins whose activities are possibly regulated by their phosphorylation/dephosphorylation.

General readings

Estornes,Y., et.al., Int. J. Cancer 121 (10), 2162-2171 (2007)
Mannherz,H.G., et.al., J. Mol. Biol. 366 (3), 745-755 (2007)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Destrin antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-DSTN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502606) Mouse IgG1 OTI2C10 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Destrin antibody

Anti-DSTN mouse monoclonal antibody (TA502607) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DSTN(RC203419). Mouse IgG1 OTI2E10 Purified Can, Hu, Mky F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Destrin antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-DSTN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502608) Mouse IgG1 OTI2F7 Purified Can, Hu, Mky F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Destrin antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-DSTN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502625) Mouse IgG2a OTI1G8 Purified Can, Hu, Mky P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Destrin antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-DSTN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502641) Mouse IgG2a OTI1C8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Destrin antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-DSTN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502642) Mouse IgG2a OTI1B8 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Destrin antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-DSTN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502653) Mouse IgG2a OTI1D5 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Destrin antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-DSTN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502654) Mouse IgG2a OTI1D8 Purified Can, Hu, Mky F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Destrin antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-DSTN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502661) Mouse IgG2a OTI1C5 Purified Hu, Mky, Rt F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Destrin (Center) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with Destrin Antibody Cat.-No AP51327PU-N, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Destrin antibody

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-DSTN monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human). Mouse IgG1 OTI2E8 Purified Hu, Mky F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Destrin antibody

Destrin Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Destrin antibody

Human MCF7; WB Suggested Anti-DSTN Antibody Titration: 0.2-1 ug/ml. Positive Control: MCF7 cell lysate. DSTN is strongly supported by BioGPS gene expression data to be expressed in Human MCF7 cells.; DSTN antibody - N-terminal region (ARP48307_P050) in Human MCF7 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Destrin (transcript variant 1)

Destrin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Destrin (1-165, His-tag)

Destrin Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

Destrin (1-165, His-tag)

Destrin Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Destrin

Destrin Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

Destrin

Destrin Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Destrin

Destrin Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Destrin

Destrin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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