Dickkopf-1 antibody

Principal name

Dickkopf-1 antibody

Alternative names for Dickkopf-1 antibody

DKK1, DKK-1, Dickkopf-related protein 1, SK

SwissProt ID

O54908 (Mouse), O94907 (Human)

Gene ID

22943 (DKK1), 13380 (Dkk1)

Available reactivities

Hu (Human), Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Gt (Goat), Hst (Hamster), Mky (Monkey), Ms (Mouse), Por (Porcine), Prim (Primate), Rb (Rabbit), Rt (Rat), Bear, Chk (Chicken), Ze (Zebrafish), African clawed frog, GP (Guinea Pig), Sh (Sheep)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Dickkopf-1 antibody

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.

General readings

Fedi P, Bafico A, Nieto Soria A, Burgess WH, Miki T, Bottaro DP, Kraus MH, Aaronson SA. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem. 1999 Jul 2;274(27):19465-72.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dickkopf-1 (C-term) antibody

  Goat Polyclonal Antibody against DKK1  
TA302464 (1µg/ml) staining of human bone marrow lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dickkopf-1 antibody

  Rabbit Polyclonal Anti-DKK1 Antibody  
Host: Rabbit; Target Name: DKK1; Sample Tissue: PANC1 Whole Cell lysates; Antibody Dilution: 1.0 ug/mlDKK1 is supported by BioGPS gene expression data to be expressed in PANC1 Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Dickkopf-1 (1st Cytopl. Dom.) antibody

  Rabbit Polyclonal Anti-DKK1 Antibody (Cytoplasmic Domain)  
Anti-DKK1 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Mky, Prim P
50 µg / €400.00
  OriGene Technologies, Inc.

Dickkopf-1 antibody

  Rabbit Polyclonal Anti-DKK1 Antibody (Internal)  
Anti-DKK1 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified GP, Gt, Hu, Rb, Sh
50 µg / €400.00
  OriGene Technologies, Inc.

Dickkopf-1 (N-term) antibody

  Rabbit Polyclonal Anti-DKK1 Antibody (N-Terminus)  
Anti-DKK1 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Elephant, Eq, Hst, Hu, Mky, Ms, Por, Prim, Rb, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

Dickkopf-1 antibody

  Rabbit Polyclonal Anti-DKK1 Antibody (N-Terminus)  
Anti-DKK1 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Eq, Hu, Mky, Por, Rb
50 µg / €400.00
  OriGene Technologies, Inc.

Dickkopf-1 antibody

Western blot analysis using DKK1 antibody Cat.-No AM06319SU-N against HEK293 (Lane 1) and DKK1-hIgGFc transfected HEK293 cell lysate (Lane 2). Mouse IgG2b 2H2 Ascites Hu WB
0.1 ml / €360.00
  Acris Antibodies GmbH

Dickkopf-1 (C-term) antibody

Placenta: Formalin-Fixed Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Gt, Hst, Hu, Mky, Ms, Platypus, Por, Prim, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Dickkopf-1 (N-term) antibody

Western blot analysis of Dickkopf-1 Antibody (N-term) Cat.-No AP51269PU-N in T47D cell line lysates (35ug/lane). DKK1 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Dickkopf-1 (C-term) antibody

Dickkopf-1 Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €450.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

Dkk1 - mouse gene knockout kit via CRISPR

Dkk1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Dkk1 - mouse gene knockout kit via CRISPR

Dkk1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dkk1 - mouse gene knockout kit via CRISPR

Dkk1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dkk1 - mouse gene knockout kit via CRISPR

Dkk1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Dickkopf-1 (full length, C-term DDK tag)

  Purified recombinant protein of Human dickkopf homolog 1 (Xenopus laevis) (DKK1), full length, with C-terminal DDK tag, expressed in sf9, 20ug  
Dickkopf-1 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
SF9 cells
20 µg / €399.00
  OriGene Technologies, Inc.

Dickkopf-1

  Purified recombinant protein of Human dickkopf homolog 1 (Xenopus laevis) (DKK1).  
Dickkopf-1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 10 µg / €399.00

Special Price: 10 µg / €239.00

  OriGene Technologies, Inc.

Dickkopf-1 (32-266, His-tag)

Recombinant human Dkk-1, aa 32-266, His-tagged: 15% SDS-PAGE (3 µg) Human Purified > 85 % by SDS - PAGE High-5 Insect cells
50 µg / €1,350.00
  Acris Antibodies GmbH

Dickkopf-1 (32-266, His-tag)

Recombinant human Dkk-1, aa 32-266, His-tagged: 15% SDS-PAGE (3 µg) Human Purified > 85 % by SDS - PAGE High-5 Insect cells
10 µg / €340.00
  Acris Antibodies GmbH

Dickkopf-1 (32-266, His-tag)

Dickkopf-1 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

Dickkopf-1 (32-266, His-tag)

Dickkopf-1 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

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