Dickkopf-2 (DKK2) antibody

Principal name

Dickkopf-2 (DKK2) antibody

Alternative names for Dickkopf-2 (DKK2) antibody

Dickkopf-related protein 2, Dkk-2

SwissProt ID

Q9QYZ8 (Mouse), Q9UBU2 (Human)

Gene ID

27123 (DKK2), 56811 (Dkk2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of Dickkopf-2 (DKK2) antibody

The Dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling; enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2.

General readings

1. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA.
Functional and structural diversity of the human Dickkopf gene family. Gene. 1999 Oct 1;238(2):301-13.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dickkopf-2 (DKK2) (C-term) antibody

  Goat Polyclonal Antibody against DKK2  
TA302770 (2µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dickkopf-2 (DKK2) antibody

  Rabbit polyclonal anti-DKK2 antibody  
Western blot analysis of Dkk2 expression in rat kidney tissue lysate. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dickkopf-2 (DKK2) antibody

  Rabbit polyclonal anti-DKK2 antibody  
Western blot analysis of Dkk2 in lysate from Jurkat cells (Lane 1,2), 3T3 cells (Lane 3) and rat kidney (Lane 4). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dickkopf-2 (DKK2) antibody

  Rabbit Polyclonal Anti-Dkk2 Antibody  
WB Suggested Anti-Dkk2 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Pancreas Rabbit IgG Purified Can, Eq, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Dickkopf-2 (DKK2) antibody

  Rabbit Polyclonal Anti-DKK2 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (DKK2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dickkopf-2 (DKK2) antibody

  Rabbit Polyclonal Anti-DKK2 Antibody  
Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane: Mouse lung tissue, Primary antibody: (DKK2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dickkopf-2 (DKK2) (N-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

Dickkopf-2 (DKK2) (C-term) antibody

Formalin-fixed and paraffin-embedded human breast carcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Dickkopf-2 (DKK2) antibody

 Dkk-2 staining of cryostat sections of 15 d.p.c. mouse embryonic tissue. Tissues were stained using anti-goat HRP-DAB (brown) and counterstained with hematoxylin (blue). Dlution 15 ug/ml. Goat IgG Aff - Purified Ms C, E, WB
0.1 mg / €450.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

DKK2 - human gene knockout kit via CRISPR

DKK2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DKK2 - human gene knockout kit via CRISPR

DKK2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DKK2 - human gene knockout kit via CRISPR

DKK2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DKK2 - human gene knockout kit via CRISPR

DKK2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dkk2 - mouse gene knockout kit via CRISPR

Dkk2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Dkk2 - mouse gene knockout kit via CRISPR

Dkk2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dkk2 - mouse gene knockout kit via CRISPR

Dkk2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dkk2 - mouse gene knockout kit via CRISPR

Dkk2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Dickkopf-2 (DKK2)

  Purified recombinant protein of Human dickkopf homolog 2 (Xenopus laevis) (DKK2)  
Dickkopf-2 (DKK2) Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

Dickkopf-2 (DKK2)

Dickkopf-2 (DKK2) Human Purified > 98 % pure by SDS-PAGE and HPLC analyses CHO cells
10 µg / €230.00
  Acris Antibodies GmbH

Dickkopf-2 (DKK2)

Dickkopf-2 (DKK2) Human Purified > 98 % pure by SDS-PAGE and HPLC analyses CHO cells
2 µg / €140.00
  Acris Antibodies GmbH

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