Dickkopf-3 (DKK3) antibody

Principal name

Dickkopf-3 (DKK3) antibody

Alternative names for Dickkopf-3 (DKK3) antibody

Dickkopf-related protein 3, Dkk-3, REIC

SwissProt ID

Q90839 (Chick), Q9QUN9 (Mouse), Q9UBP4 (Human)

Gene ID

27122 (DKK3), 50781 (Dkk3), 827122 (ATARD2)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of Dickkopf-3 (DKK3) antibody

The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-l1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains.  Playing an important regulatory role in vertebrate development through localized inhibition of Wnt regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane coreceptors Kremen-1 (Krm1) and Kremen-2 (Krm2).

General readings

Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA.
Functional and structural diversity of the human Dickkopf gene family.
Gene. 1999 Oct 1;238(2):301-13.
PMID: 10570958

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Dickkopf-3 (DKK3) antibody

Western blot analysis of extracts of mouse brain lines, using DKK3 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dickkopf-3 (DKK3) (C-term) antibody

TA302465 staining (2µg/ml) of HEK293 lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dickkopf-3 (DKK3) antibody

Sample (50 ug of whole cell lysate). A: Mouse brain. 10% SDS PAGE. TA308781 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dickkopf-3 (DKK3) antibody

Western blot analysis of Dkk3 using rat kidney tissue lysate. Rabbit Purified Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Dickkopf-3 (DKK3) antibody

Western blot analysis of extracts from Jurkat cells, using DDK3 antibody. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Dickkopf-3 (DKK3) antibody

Western blot analysis using DKK3 antibody Cat.-No AM06401SU-N against HEK293 (Lane 1), MCF-7 (Lane 2) and HL7702 (Lane 3) cell lysate. Mouse IgG1 4G7 Ascites Hu, Mky E, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

Dickkopf-3 (DKK3) (N-term) antibody

Figure 3. Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with DKK3 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Dickkopf-3 (DKK3) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with DKK3 polyclonal antibody ( Cat # PAB3571 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Dickkopf-3 (DKK3) antibody

DKK3 polyclonal antibody ( Cat # PAB6129 ) staining ( 2 µg/ml ) of HEK 293T ( Bosc 23) lysate ( RIPA buffer, 30 µg total protein per lane ) . Primary incubated for 12 hour. Detected by western blot using chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Dickkopf-3 (DKK3) antibody

Western blot analysis of Dkk3 using rat kidney tissue lysate. Rabbit Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Dickkopf-3 (DKK3) antibody

Immunohistochemistry-Paraffin: DKK3 Antibody [NB100-899] - (5ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Dickkopf-3 (DKK3) antibody

Western Blot: DKK3 Antibody [NBP1-45522] - Western blot analysis of Dkk3 using rat kidney tissue lysate. Rabbit IgG Aff - Purified Ms, Rt WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Dickkopf-3 (DKK3) antibody

Western Blot: DKK3 Antibody (4G7) [NBP1-51605] - Western blot analysis using DKK3 mouse mAb against HEK293 (1), MCF-7 (2) and HL7702 (3) cell lysate. Mouse IgG1 4G7 Purified Hu, Mky E, F, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Dickkopf-3 (DKK3) (transcript variant 1)

Dickkopf-3 (DKK3) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Dickkopf-3 (DKK3) (transcript variant 3)

Dickkopf-3 (DKK3) Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €299.00
  OriGene Technologies, Inc.

Dickkopf-3 (DKK3)

Dickkopf-3 (DKK3) Human Purified > 98 % pure by SDS-PAGE and HPLC analyses CHO cells
10 µg / €230.00
  Acris Antibodies GmbH

Dickkopf-3 (DKK3)

Dickkopf-3 (DKK3) Human Purified > 98 % pure by SDS-PAGE and HPLC analyses CHO cells
2 µg / €140.00
  Acris Antibodies GmbH

Dickkopf-3 (DKK3)

Dickkopf-3 (DKK3) Human Purified > 98 % by SDS-PAGE & HPLC analysis CHO cells
10 µg / €330.00
  Acris Antibodies GmbH

Dickkopf-3 (DKK3) (22-350, His-tag)

Dickkopf-3 (DKK3) Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

Dickkopf-3 (DKK3) (22-350, His-tag)

Dickkopf-3 (DKK3) Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

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