DIO2 antibody

Principal name

DIO2 antibody

Alternative names for DIO2 antibody

DIOII, ITDI2, TXDI2, Type II iodothyronine deiodinase, Type-II 5'-deiodinase

SwissProt ID

P70551 (Rat), Q5I3B2 (Bovin), Q6QN12 (Pig), Q92813 (Human), Q9IAX2 (Chick), Q9Z1Y9 (Mouse)

Gene ID

1734 (DIO2)

Available reactivities

Ms (Mouse), Hu (Human), Por (Porcine), Rt (Rat)

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F)

Background of DIO2 antibody

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

General readings

Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, Williams GH. Ala92 Type 2 Deiodinase Allele Increases Risk for the Development of Hypertension. Hypertension. 2007 Jan 15; [Epub ahead of print] PMID: 17224473

  1. Quick-Filters:
  2. Cited (1)

5 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DIO2 antibody

TA305836 (2ug/ml) staining of PFA-fixed cryo-sectioned Mouse Hippocampus. Microwaved antigen retrieval with citrate buffer pH 4.5, HRP-staining. Goat IgG Aff - Purified Hu, Ms, Por, Rt C, E
0.1 mg / €325.00
  OriGene Technologies, Inc.

DIO2 (Center) antibody

AP17989PU-N DIO2 Antibody  staining of Formalin Fixed and Paraffin Embedded Mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the mouse DIO2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DIO2 antibody

DIO2 Goat Ms E
0.1 mg / €400.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  


DIO2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.


DIO2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

5 Item(s)

per page
  • LinkedIn