DIO3 antibody

Principal name

DIO3 antibody

Alternative names for DIO3 antibody

ITDI3, TXDI3, Type 3 DI, DIOIII, 5DIII, Type III iodothyronine deiodinase, Type-III 5'-deiodinase

SwissProt ID

O42412 (Chick), P49897 (Rat), P49899 (Xenla), P55073 (Human), Q5I3B1 (Bovin), Q6DN07 (Sheep), Q6QN11 (Pig), Q91ZI8 (Mouse)

Gene ID

1735 (DIO3), 29475 (Dio3), 107585

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of DIO3 antibody

DIO3 (deiodinase, iodothyronine, type III), also known as D3, 5DIII, TXDI3 or DIOIII, is a single-pass type II membrane protein that belongs to the iodothyronine deiodinase family of proteins. Members of the iodothyronine deiodinase family play an important role in thyroid hormone metabolism. Expressed in placenta and various fetal tissues, DIO3 localizes to the cell membrane and plays an important role regulating the activity of thyroid hormones during morphogenesis. More specifically, DIO3 functions as the major physiologic inactivator of thyroid hormones, catalyzing the inner-ring deiodination (the removal of iodine groups) of 3,5,3',5'-tetraiodothyronine (T4) and 3,5,3'-triiodothyronine (T3) to their inactive metabolites 3,3',5'-triiodothyronine (RT3 or reverse T3) and 3,3'-diiodothyronine (T2), respectively. Through its ability to inactivate thyroid hormones, DIO3 effects thermoregulation, gene expression and energy metabolism, as well as a number of other important reactions in cell maintenance and differentiation.

General readings

Bessho, K., et al. Eur. J. Pediatr. 169(2):215-221 (2010).
Wallace, C., et al. Nat. Genet. 42(1):68-71 (2010).
Aerts, G., et al. Endocrinology 150(11):5171-5180 (2009).
Panicker, V., et al. J. Clin. Endocrinol. Metab. 94(5):1623-1629 (2009).
Panicker, V., et al. J. Clin. Endocrinol. Metab. 93(8):3075-3081 (2008).

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DIO3 antibody

Western blot (WB) analysis of DIO3 antibody (Cat.-No.: AP20592PU-N) in extracts from HUVEC cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

DIO3 (C-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DIO3 Antibody (C-term) Cat.-No AP51263PU-N, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

DIO3 - human gene knockout kit via CRISPR

DIO3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DIO3 - human gene knockout kit via CRISPR

DIO3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DIO3 - human gene knockout kit via CRISPR

DIO3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DIO3 - human gene knockout kit via CRISPR

DIO3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dio3 - mouse gene knockout kit via CRISPR

Dio3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dio3 - mouse gene knockout kit via CRISPR

Dio3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Dio3 - mouse gene knockout kit via CRISPR

Dio3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DIO3 (mGFP-tagged) - Human deiodinase, iodothyronine, type III (DIO3), (Note: selenocystein protein, Internal stop codon present. See Summary below), 200 uL, >10^7 TU/mL

Lenti ORF particles, DIO3 (mGFP-tagged) - Human deiodinase, iodothyronine, type III (DIO3), (Note: selenocystein protein, Internal stop codon present. See Summary below), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, DIO3 (Myc-DDK-tagged)-Human deiodinase, iodothyronine, type III (DIO3), (Note, selenocystein protein, internal stop codon, see summary), 200 uL, >10^7 TU/mL

Lenti ORF particles, DIO3 (Myc-DDK-tagged)-Human deiodinase, iodothyronine, type III (DIO3), (Note, selenocystein protein, internal stop codon, see summary), 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, 2810407C02Rik (GFP-tagged) - Mouse RIKEN cDNA 2810407C02 gene (2810407C02Rik), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below), 200 uL, >10^7 TU/mL

Lenti ORF particles, 2810407C02Rik (GFP-tagged) - Mouse RIKEN cDNA 2810407C02 gene (2810407C02Rik), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below), 200 uL, >10^7 TU/mL  
200 µl / €990.00
  OriGene Technologies, Inc.

Lenti ORF particles, 2810407C02Rik (Myc-DDK-tagged) - Mouse RIKEN cDNA 2810407C02 gene (2810407C02Rik), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below), 200 uL, >10^7 TU/mL

Lenti ORF particles, 2810407C02Rik (Myc-DDK-tagged) - Mouse RIKEN cDNA 2810407C02 gene (2810407C02Rik), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dio3 (GFP-tagged ORF) - Rat deiodinase, iodothyronine, type III (Dio3), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dio3 (GFP-tagged ORF) - Rat deiodinase, iodothyronine, type III (Dio3), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Dio3 (Myc-DDK-tagged ORF) - Rat deiodinase, iodothyronine, type III (Dio3), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below), 200 uL, >10^7 TU/mL

Lenti ORF particles, Dio3 (Myc-DDK-tagged ORF) - Rat deiodinase, iodothyronine, type III (Dio3), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

15 Item(s)

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