DIO3 antibody

Principal name

DIO3 antibody

Alternative names for DIO3 antibody

ITDI3, TXDI3, Type 3 DI, DIOIII, 5DIII, Type III iodothyronine deiodinase, Type-III 5'-deiodinase

SwissProt ID

O42412 (Chick), P49897 (Rat), P49899 (Xenla), P55073 (Human), Q5I3B1 (Bovin), Q6DN07 (Sheep), Q6QN11 (Pig), Q91ZI8 (Mouse)

Gene ID

1735 (DIO3), 29475 (Dio3), 107585

Available reactivities

Ms (Mouse), Rt (Rat), Hst (Hamster), Hu (Human), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of DIO3 antibody

DIO3 (deiodinase, iodothyronine, type III), also known as D3, 5DIII, TXDI3 or DIOIII, is a single-pass type II membrane protein that belongs to the iodothyronine deiodinase family of proteins. Members of the iodothyronine deiodinase family play an important role in thyroid hormone metabolism. Expressed in placenta and various fetal tissues, DIO3 localizes to the cell membrane and plays an important role regulating the activity of thyroid hormones during morphogenesis. More specifically, DIO3 functions as the major physiologic inactivator of thyroid hormones, catalyzing the inner-ring deiodination (the removal of iodine groups) of 3,5,3',5'-tetraiodothyronine (T4) and 3,5,3'-triiodothyronine (T3) to their inactive metabolites 3,3',5'-triiodothyronine (RT3 or reverse T3) and 3,3'-diiodothyronine (T2), respectively. Through its ability to inactivate thyroid hormones, DIO3 effects thermoregulation, gene expression and energy metabolism, as well as a number of other important reactions in cell maintenance and differentiation.

General readings

Bessho, K., et al. Eur. J. Pediatr. 169(2):215-221 (2010).
Wallace, C., et al. Nat. Genet. 42(1):68-71 (2010).
Aerts, G., et al. Endocrinology 150(11):5171-5180 (2009).
Panicker, V., et al. J. Clin. Endocrinol. Metab. 94(5):1623-1629 (2009).
Panicker, V., et al. J. Clin. Endocrinol. Metab. 93(8):3075-3081 (2008).

Items 1 to 20 of 21 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DIO3 antibody

Western blot (WB) analysis of DIO3 antibody (Cat.-No.: AP20592PU-N) in extracts from HUVEC cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

DIO3 (C-term) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DIO3 Antibody (C-term) Cat.-No AP51263PU-N, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

DIO3 antibody

Detection of Dio3 in rat placenta using Dio3 polyclonal antibody ( Cat # PAB12111 ). Rabbit Ms, Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

DIO3 antibody

Detection of Dio3 in rat placenta using Dio3 polyclonal antibody ( Cat # PAB12112 ). Rabbit Ms, Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

DIO3 antibody

Western blot analysis of DIO3 expression in HepG2 (A) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

DIO3 antibody

Western blot analysis of DIO3 expression in HepG2 (A) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

DIO3 antibody

Western blot analysis of DIO3 expression in HepG2 (A) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

DIO3 antibody

Western Blot: Dio3 Antibody [NB110-96414] Detection of Dio3 in rat placenta Rabbit Aff - Purified Hst, Ms, Rt ICC/IF, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

DIO3 antibody

DIO3 Rabbit Biotin Ms, Rt WB
0.1 ml / €360.00
  Novus Biologicals Inc.

DIO3 antibody

DIO3 Rabbit DyLight488 Ms, Rt WB
0.1 ml / €390.00
  Novus Biologicals Inc.

DIO3 antibody

DIO3 Rabbit HRP Ms, Rt WB
0.1 ml / €390.00
  Novus Biologicals Inc.

DIO3 control peptide

DIO3 ICC/IF
50 µg / €140.00
  Novus Biologicals Inc.

DIO3 antibody

DIO3 Rabbit Aff - Purified Hst, Ms, Rt ICC/IF, WB
25 µl / €170.00
  Novus Biologicals Inc.

DIO3 antibody

Western Blot: Dio3 Antibody [NBP1-05767]- Detection of Dio3 in rat placenta Rabbit Aff - Purified Hu, Ms, Rb, Rt WB
0.1 ml / €380.00
  Novus Biologicals Inc.

DIO3 antibody

DIO3 Rabbit Biotin Ms, Rt WB
0.1 ml / €360.00
  Novus Biologicals Inc.

DIO3 antibody

DIO3 Rabbit DyLight488 Ms, Rt WB
0.1 ml / €390.00
  Novus Biologicals Inc.

DIO3 antibody

DIO3 Rabbit HRP Ms, Rt WB
0.1 ml / €390.00
  Novus Biologicals Inc.

DIO3 control peptide

DIO3
50 µg / €140.00
  Novus Biologicals Inc.

DIO3 antibody

DIO3 Rabbit Aff - Purified Hu, Ms, Rb, Rt WB
25 µl / €200.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DIO3

DIO3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Items 1 to 20 of 21 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn