DIRAS3 antibody

Principal name

DIRAS3 antibody

Alternative names for DIRAS3 antibody

Di-Ras3, ARHI, NOEY2, RHOI, GTP-binding protein Di-Ras3, Distinct subgroup of the Ras family member 3, Rho-related GTP-binding protein RhoI

SwissProt ID

O95661 (Human)

Gene ID

9077 (DIRAS3)

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of DIRAS3 antibody

DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paterl allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K sigling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kise kises (MEK) to restrict cell migration (3).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DIRAS3 antibody

Western blot analysis of DIRAS3 in human testis tissue lysate with DIRAS3 antibody at 1 ug/mL. Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DIRAS3 antibody

DIRAS3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

DIRAS3 antibody

DIRAS3 Mouse IgM 1G4 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

DIRAS3 antibody

Immunohistochemistry-Paraffin: ARHI Antibody [NBP1-90104] Immunohistochemical staining of human breast shows moderate cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

DIRAS3 antibody

Immunohistochemistry-Paraffin: ARHI Antibody [NBP1-90105] - Immunohistochemical staining of human cerebellum shows strong nuclear positivity in purkinje cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

DIRAS3 antibody

Immunohistochemistry-Paraffin: ARHI Antibody [NBP1-90106] - Immunohistochemical staining of human esophagus shows strong cytoplasmic positivity in squamous epithelial cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DIRAS3

DIRAS3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

DIRAS3

DIRAS3 Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

DIRAS3

DIRAS3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

DIRAS3

DIRAS3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

DIRAS3 overexpression lysate

DIRAS3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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