DIS3-like exonuclease 1 antibody

Principal name

DIS3-like exonuclease 1 antibody

Alternative names for DIS3-like exonuclease 1 antibody

DIS3L, KIAA1955, MGC4562

SwissProt ID

A0JN80 (Bovin), Q5U2P0 (Rat), Q8C0S1 (Mouse), Q8TF46 (Human)

Gene ID

115752 (DIS3L)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of DIS3-like exonuclease 1 antibody

The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3’ to 5’ exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3’ regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DIS3-like exonuclease 1 antibody

Western Blot analysis of DIS3L expression in transfected 293T cell line (H00115752-T01) by DIS3L MaxPab polyclonal antibody.

Lane 1: MGC4562 transfected lysate(106.81 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

DIS3-like exonuclease 1 antibody

MGC4562 MaxPab polyclonal antibody. Western Blot analysis of MGC4562 expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

DIS3-like exonuclease 1 antibody

Immunohistochemistry-Paraffin: DIS3L Antibody [NBP1-81941] - Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DIS3-like exonuclease 1 (transcript variant 2)

DIS3-like exonuclease 1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

DIS3-like exonuclease 1

DIS3-like exonuclease 1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

DIS3-like exonuclease 1

DIS3-like exonuclease 1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MGC4562 293T Cell Transient Overexpression Lysate(Denatured)

MGC4562 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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