Disembodied antibody

Principal name

Disembodied antibody

Alternative names for Disembodied antibody

Cytochrome P450 302a1, dib, CYP302A1, CG12028

SwissProt ID

Q9NGX9 (Drome)

Gene ID

45282 (dib)

Ncbi ID


Available reactivities

Dros (Drosophila)

Available hosts


Available applications

Frozen Sections (C)

Background of Disembodied antibody

In Fruit Fly (Drosophila melanogaster) steroid hormones play an important role in the reproduction, development and homeostasis between transitions between various stages of development (1). In D melonogaster the hormone ecdysone (E) is converted to 20-hydroxyacdysone by a P450 enzyme in peripheral target tissue. The genomic and regulatory effect of this hormone are mediated by activation of a nuclear hormone receptor an activation of transcriptional cascade (2). Recently it has been shown that a product of the Disemboided locus as being potentially involved in the production control of ecdysteroid as a member of the cytochrme P450 family monooxygenese (CYP302A). Mutation in the Disemboided protein result in a number of distinct phenotypes in D. melonogaster including disruption in dorsal closure, head evolution, gut morphogenesis, and failure to produce embryonic cuticle. Most of these disruptions are the result of low affinity of 20E to its receptor due to significant reduction in the expression of IMP-E1 gene. Several other mutations in the “Halloween” group of proteins, including Shadow (sad) also resulted in similar phenotypes (3, 4). The co-expression of dib and sad causes increased metabolism of ketotriol to ecdyson (2) and the two proteins are concentrated with in the individual segment (2).

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