DKC1 / NOLA4 antibody

Principal name

DKC1 / NOLA4 antibody

Alternative names for DKC1 / NOLA4 antibody

Dyskerin, Nucleolar protein NAP57, CBF5 homolog, H/ACA ribonucleoprotein complex subunit 4, Nucleolar protein family A member 4, snoRNP protein DKC1, Nopp140-associated protein of 57 kDa

SwissProt ID

O60832 (Human), P40615 (Rat), Q5ZJH9 (Chick), Q9ESX5 (Mouse)

Gene ID

1736 (DKC1), 170944 (Dkc1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Hst (Hamster), Mky (Monkey), Prim (Primate), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Rb (Rabbit), Eq (Equine), GP (Guinea Pig), Gt (Goat), Sh (Sheep), Ye (Yeast), Ze (Zebrafish)

Available hosts

Rabbit, Goat, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of DKC1 / NOLA4 antibody

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rR processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rR production and rR pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, il dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.

General readings

Yoon A, Peng G, Brandenburger Y, Zollo O, Xu W, Rego E, Ruggero D.
Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita.
Science. 2006 May 12;312(5775):902-6. Erratum in: Science. 2006 Sep;313(5791):1238. Brandenburg, Yves .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DKC1 / NOLA4 antibody

  Goat Anti-DKC1 Antibody  
TA305629 (5ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu, Ms P
0.1 mg / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

  Rabbit polyclonal anti-Dyskerin antibody  
Western blot analysis of extracts from HeLa cells, using Dyskerin antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

  Anti-DKC1 Rabbit Polyclonal Antibody  
Predicted band size: 58 kDa . Positive control: Hela and MCF7 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane1: Hela cell lysate Lane2: MCF7 cell lysate Lysate: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

  Rabbit polyclonal DKC1 Antibody (Center)  
DKC1 Antibody (Center) (Cat.#TA324811) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the DKC1 antibody detected DKC1 protein (arrow). Rabbit IgG Purified Hu, Ms ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

  Rabbit anti-DKC1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using DKC1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

  Rabbit Polyclonal Anti-DKC1 Antibody  
WB Suggested Anti-DKC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Small Intestine Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh, Ye, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

  Rabbit Polyclonal Anti-Dyskerin Antibody  
Western blot analysis on HeLa cell lysate using Dyskerin Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

Western blot (WB) analysis of Dyskerin antibody (Cat.-No.: AP06643PU-N) at 1/500 dilution Lane1:A549 cell lysate Lane2:Mouse brain tissue lysate Lane3:Rat brain tissue lysate Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

DKC1 / NOLA4 (446-460) antibody

AP08575PU-N at 5 µg/ml staining DKC1 in Formalin-Fixed Paraffin-Embedded Human Spleen tissue by Immunohistochemistry. Goat IgG Aff - Purified Hst, Hu, Mky, Ms, Prim E, P
50 µg / €470.00
  Acris Antibodies GmbH

DKC1 / NOLA4 antibody

Immunofluorescence analysis of HeLa cells, using Dyskerin Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

DKC1 / NOLA4 antibody

Immunofluorescence analysis of HeLa cells, using Dyskerin Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

DKC1 - human gene knockout kit via CRISPR

DKC1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DKC1 - human gene knockout kit via CRISPR

DKC1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DKC1 - human gene knockout kit via CRISPR

DKC1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DKC1 - human gene knockout kit via CRISPR

DKC1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

DKC1 overexpression lysate

DKC1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

DKC1 overexpression lysate

DKC1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DKC1 (mGFP-tagged) - Human dyskeratosis congenita 1, dyskerin (DKC1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, DKC1 (mGFP-tagged) - Human dyskeratosis congenita 1, dyskerin (DKC1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, DKC1 (mGFP-tagged) - Human dyskeratosis congenita 1, dyskerin (DKC1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, DKC1 (mGFP-tagged) - Human dyskeratosis congenita 1, dyskerin (DKC1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, DKC1 (Myc-DDK tagged) - Human dyskeratosis congenita 1, dyskerin (DKC1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, DKC1 (Myc-DDK tagged) - Human dyskeratosis congenita 1, dyskerin (DKC1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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