DKC1 / NOLA4 antibody

Principal name

DKC1 / NOLA4 antibody

Alternative names for DKC1 / NOLA4 antibody

Dyskerin, Nucleolar protein NAP57, CBF5 homolog, H/ACA ribonucleoprotein complex subunit 4, Nucleolar protein family A member 4, snoRNP protein DKC1, Nopp140-associated protein of 57 kDa

SwissProt ID

O60832 (Human), P40615 (Rat), Q5ZJH9 (Chick), Q9ESX5 (Mouse)

Gene ID

1736 (DKC1), 100173609 (YWHAZ)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Rb (Rabbit), Eq (Equine), GP (Guinea Pig), Gt (Goat), Sh (Sheep), Ye (Yeast), Ze (Zebrafish)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C)

Background of DKC1 / NOLA4 antibody

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Yoon A, Peng G, Brandenburger Y, Zollo O, Xu W, Rego E, Ruggero D.
Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita.
Science. 2006 May 12;312(5775):902-6. Erratum in: Science. 2006 Sep;313(5791):1238. Brandenburg, Yves .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DKC1 / NOLA4 antibody

Immunoperoxidase of purified MaxPab antibody to DKC1 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml] Mouse Purified Hu E(detection), ICC/IF, P, WB
50 µg / €370.00
  Abnova Taiwan Corp.

DKC1 / NOLA4 antibody

TA305629 (5ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu, Ms P
0.1 mg / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

Western blot analysis of extracts from HeLa cells, using Dyskerin antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

Predicted band size: 58 kDa . Positive control: Hela and MCF7 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane1: Hela cell lysate Lane2: MCF7 cell lysate Lysate: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

DKC1 Antibody (Center) (Cat.#TA324811) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the DKC1 antibody detected DKC1 protein (arrow). Rabbit IgG Purified Hu, Ms ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

Western blot analysis of extracts of various cell lines, using DKC1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

WB Suggested Anti-DKC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Small Intestine Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh, Ye, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

Western blot analysis on HeLa cell lysate using Dyskerin Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DKC1 / NOLA4 antibody

Western blot (WB) analysis of Dyskerin antibody (Cat.-No.: AP06643PU-N) at 1/500 dilution Lane1:A549 cell lysate Lane2:Mouse brain tissue lysate Lane3:Rat brain tissue lysate Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

DKC1 / NOLA4 (446-460) antibody

AP08575PU-N at 5 µg/ml staining DKC1 in Formalin-Fixed Paraffin-Embedded Human Spleen tissue by Immunohistochemistry. Goat IgG Aff - Purified Hst, Hu, Mky, Ms, Prim E, P
50 µg / €470.00
  Acris Antibodies GmbH

DKC1 / NOLA4 antibody

DKC1 / NOLA4 Mouse IgG2a 3E10 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

DKC1 / NOLA4 antibody

DKC1 / NOLA4 Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

DKC1 / NOLA4 antibody

Immunofluorescence analysis of HeLa cells, using Dyskerin Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

DKC1 / NOLA4 antibody

Immunofluorescence analysis of HeLa cells, using Dyskerin Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

DKC1 / NOLA4 antibody

Human Small Intestine; WB Suggested Anti-DKC1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Small Intestine; DKC1 antibody - N-terminal region (ARP40357_P050) in Human Small Intestine cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

DKC1 / NOLA4 antibody

Immunohistochemistry-Paraffin: DKC1 Antibody [NB100-59738] - NB100-59738(5ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

DKC1 / NOLA4 antibody

Western Blot: DKC1 Antibody [NBP1-41064]-Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells.  Affinity purified rabbit anti-DKC1 antibody used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 10 mcg/mg lysate.  DKC1 was also immunoprecipitated by rabbit anti-DKC1 antibody NBP!-41065, which recognizes a downstream epitope Rabbit Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

DKC1 / NOLA4 antibody

DKC1 / NOLA4 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

DKC1 / NOLA4 antibody

DKC1 / NOLA4 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €290.00
  Novus Biologicals Inc.

DKC1 / NOLA4 antibody

Immunohistochemistry-Paraffin: DKC1 Antibody [NBP1-85156] - Immunohistochemical staining of human cerebral cortex shows strong nucleolar positivity in neuronal cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

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