DLAT / DLTA antibody

Principal name

DLAT / DLTA antibody

Alternative names for DLAT / DLTA antibody

Pyruvate dehydrogenase complex E2 subunit, M2 antigen, PBC, PDCE2, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, M2 antigen complex 70 kDa subunit

SwissProt ID

P08461 (Rat), P10515 (Human), Q8BMF4 (Mouse)

Gene ID

1737 (DLAT), 7173781 (IPR000890)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), African clawed frog, Ce (C. elegans), Dros (Drosophila)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Immunoprecipitation (IP), Frozen Sections (C)

Background of DLAT / DLTA antibody

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogese complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogese E2 deficiency which causes primary lactic acidosis in infancy and early childhood

General readings

Head,R.A., (2005) Ann. Neurol. 58 (2), 234-241

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DLAT / DLTA antibody

Immunofluorescence of purified MaxPab antibody to DLAT on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu, Rt E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

DLAT / DLTA antibody

Western blot detection of Pyruvate Dehydrogenase E2 in Jurkat,A549,U251,F9,Lncap and Hela cell lysates using Pyruvate Dehydrogenase E2 mouse mAb (1:1000 diluted).Predicted band size:69KDa.Observed band size:69KDa. Mouse IgG1 4A4-B6-C10 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DLAT / DLTA antibody

DLAT / DLTA Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

DLAT / DLTA antibody

Human Kidney; Rabbit Anti-DLAT Antibody. Catalog Number: ARP41994. Paraffin Embedded Tissue: Human Kidney. Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; DLAT antibody - N-terminal region (ARP41994_T100) in Human Kidney cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt, Ze P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

DLAT / DLTA antibody

Human HepG2; WB Suggested Anti-DLAT Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate. DLAT is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells.; DLAT antibody - C-terminal region (ARP41995_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Can, Ce, Chk, Dros, Hu, Ms, Por, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DLAT / DLTA

DLAT / DLTA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

DLAT / DLTA

DLAT / DLTA Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

DLAT / DLTA

DLAT / DLTA Human
10 µg / €380.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

DLAT 293T Cell Transient Overexpression Lysate(Denatured)

DLAT 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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