DLAT / DLTA antibody

Principal name

DLAT / DLTA antibody

Alternative names for DLAT / DLTA antibody

Pyruvate dehydrogenase complex E2 subunit, M2 antigen, PBC, PDCE2, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, M2 antigen complex 70 kDa subunit

SwissProt ID

P08461 (Rat), P10515 (Human), Q8BMF4 (Mouse)

Gene ID

1737 (DLAT), 235339 (Dlat)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), African clawed frog, Ce (C. elegans), Dros (Drosophila), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of DLAT / DLTA antibody

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogese complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogese E2 deficiency which causes primary lactic acidosis in infancy and early childhood

General readings

Head,R.A., (2005) Ann. Neurol. 58 (2), 234-241

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DLAT / DLTA antibody

  Rabbit Polyclonal Anti-DLAT Antibody  
WB Suggested Anti-DLAT Antibody Titration: 5.0 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DLAT / DLTA antibody

  Rabbit Polyclonal Anti-DLAT Antibody  
WB Suggested Anti-DLAT Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: HepG2 cell lysate.DLAT is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells Rabbit IgG Purified Can, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

DLAT / DLTA antibody

  Mouse Monoclonal Pyruvate Dehydrogenase E2 Antibody  
Western blot detection of Pyruvate Dehydrogenase E2 in Jurkat,A549,U251,F9,Lncap and Hela cell lysates using Pyruvate Dehydrogenase E2 mouse mAb (1:1000 diluted).Predicted band size:69KDa.Observed band size:69KDa. Mouse IgG1 4A4-B6-C10 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

DLAT - human gene knockout kit via CRISPR

DLAT - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

DLAT - human gene knockout kit via CRISPR

DLAT - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

DLAT - human gene knockout kit via CRISPR

DLAT - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

DLAT - human gene knockout kit via CRISPR

DLAT - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DLAT / DLTA

  Recombinant protein of human dihydrolipoamide S-acetyltransferase (DLAT)  
DLAT / DLTA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, DLAT (mGFP-tagged) - Human dihydrolipoamide S-acetyltransferase (DLAT), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, DLAT (mGFP-tagged) - Human dihydrolipoamide S-acetyltransferase (DLAT), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, DLAT (Myc-DDK tagged) - Human dihydrolipoamide S-acetyltransferase (DLAT), nuclear gene encoding mitochondrial protein , 200 uL, >10^7 TU/mL

Lenti ORF particles, DLAT (Myc-DDK tagged) - Human dihydrolipoamide S-acetyltransferase (DLAT), nuclear gene encoding mitochondrial protein , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Dlat (GFP-tagged) - Mouse dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, Dlat (GFP-tagged) - Mouse dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €1,300.00
  OriGene Technologies, Inc.

Lenti ORF particles, Dlat (Myc-DDK-tagged) - Mouse dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL

Lenti ORF particles, Dlat (Myc-DDK-tagged) - Mouse dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), nuclear gene encoding mitochondrial protein, 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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