DLG2 / PSD93 antibody

Principal name

DLG2 / PSD93 antibody

Alternative names for DLG2 / PSD93 antibody

Disks large homolog 2, PSD-93, Chapsyn-110, Postsynaptic density protein PSD-93, Channel-associated protein of synapse-110

SwissProt ID

Q15700 (Human), Q63622 (Rat), Q91XM9 (Mouse)

Gene ID

64053 (Dlg2), 1740 (DLG2)

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse), Ze (Zebrafish), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of DLG2 / PSD93 antibody

Post Synaptic Density 93 (PSD-93), also known as chapsyn-110, is one of a family of plasma membrane-associated proteins found in synaptic junctions. PSD-93 is unique among family members in its expression in Purkinje neuron cell bodies and dendrites. PSD-93 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity.
PSD-93 is believed to participate in the clustering of certain proteins, including N-methyl-D-aspartate (NMDA) receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD-93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with PSD-93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

General readings

General / background references:Gomperts SN Clustering membrane proteins: It's all coming together with the PSD-95/SAP90 protein family. Cell 84:659-62 (1996). PubMed PMID: 8625403
Kim E et al. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. Neuron 17:103-13 (1996). PubMed PMID: 8755482
Brenman JE et al. Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein. J Neurosci 16:7407-15 (1996). PubMed PMID: 8922396

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DLG2 / PSD93 antibody

Adult rat brain hippocampus immunohistochemistry. Mouse IgG1 N18/30 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

DLG2 / PSD93 antibody

Adult rat brain cerebellum immunohistochemistry. Mouse IgG2a N18/28 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

DLG2 / PSD93 antibody

Adult rat brain hippocampus immunohistochemistry. Mouse IgG1 N18/30 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

DLG2 / PSD93 antibody

Adult rat brain cerebellum immunohistochemistry. Mouse IgG2a N18/28 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

DLG2 / PSD93 antibody

Western blot analysis of extracts from HepG2 cells and HuvEc cells, using DLG2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

DLG2 / PSD93 (1-852) antibody

Western blot analysis of Chapsyn-110 in rat brain membrane lysates using a 1:1000 dilution of the antibody Mouse IgG1 S18-30 Purified Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

DLG2 / PSD93 antibody

Western blot analysis of rat brain membranes: 1. Anti-Chapsyn 110 antibody , (1:1000). 2. Anti-Chapsyn 110 antibody, preincubated with the control fusion protein antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

DLG2 / PSD93 antibody

WB Suggested Anti-DLG2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified GP, Hu, Ms, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

DLG2 / PSD93 antibody

Human Jurkat; WB Suggested Anti-DLG2 Antibody Titration: 0.2-1 ug/ml. Positive Control: Jurkat cell lysate; DLG2 antibody - N-terminal region (ARP43637_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

DLG2 / PSD93 antibody

Western blot analysis of PSD93 expression in Jurkat (A); SHSY5Y (B); HepG2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

DLG2 / PSD93 antibody

Western blot analysis of PSD93 expression in Jurkat (A); SHSY5Y (B); HepG2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

DLG2 / PSD93 antibody

Western blot analysis of PSD93 expression in Jurkat (A); SHSY5Y (B); HepG2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

DLG2 / PSD93 antibody

Figure 1 shows immunolocalization of PSD-93 in rat cerebellum using NB 300-546. Rabbit Aff - Purified Rt C, ICC/IF, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

DLG2 / PSD93 antibody

Western Blot: PSD93 Antibody [NBP1-59715] - This Anti-DLG2 antibody was used in Western Blot of Jurkat tissue lysate at a concentration of 0.5ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

DLG2 / PSD93 (transcript variant 4)

DLG2 / PSD93 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

DLG2 overexpression lysate

DLG2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

DLG2 overexpression lysate

DLG2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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