DLG4 / PSD95 antibody

Principal name

DLG4 / PSD95 antibody

Alternative names for DLG4 / PSD95 antibody

DLGH4, PSD-95, Disks large homolog 4, SAP90, SAP-90, Postsynaptic density protein 95, Synapse-associated protein 90

SwissProt ID

P31016 (Rat), P78352 (Human), Q62108 (Mouse)

Gene ID

13385 (Dlg4), 1742 (DLG4), 29495

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Xen (Xenopus), Bov (Bovine), Ze (Zebrafish), Can (Canine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunoelectron Microscopy (EM), Paraffin Sections (P)

Background of DLG4 / PSD95 antibody

Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain.
PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

DLG4 / PSD95 antibody

  Mouse Monoclonal Anti-PSD95 Antibody  
Western blot analysis of PSD95 in rat membrane using a 1:1000 dilution of the antibody Mouse IgG2a 6G6 Purified Bov, Hu, Ms, Rt C, F, WB
0.1 mg / €386.00
  OriGene Technologies, Inc.

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